Screening of critical factors influencing the efficient hydrolysis of zeaxanthin dipalmitate in an adapted in vitro- digestion model

Wen, Xin; Hempel, Judith C.; Schweiggert, Ralf M.; Wang, Yuxiao; Ni, Yingdong; Carle, Reinhold

doi:10.1016/j.foodchem.2018.02.116

Cited by 22 publications

(23 citation statements)

References 46 publications

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“…Furthermore, foods rich in carotenoid esters require further adaptions of the model to allow the simulation of intestinal carotenoid ester cleavage. First models aiming at the improvements of carotenoid ester cleavage have emerged recently . The background of such further improvements is discussed below.…”

Section: In Vitro Digestion Modelsmentioning

confidence: 99%

“…However, this might be highly complex because the in vitro cleavage as catalyzed by porcine cholesterol esterase has only been highly effective for β ‐cryptoxanthin esters . Esters of lutein, zeaxanthin, cryptocapsin and capsanthin have been showed to be only poorly cleaved . Breithaupt et al .…”

Section: Factors Affecting Carotenoid Bioaccessibilitymentioning

confidence: 99%

“…As a result of low cleavage turnovers, Wen et al . aimed to identify approaches that increased the efficiency, considering the example of the commonly poorly cleaved zeaxanthin diesters.…”

Section: Factors Affecting Carotenoid Bioaccessibilitymentioning

confidence: 99%

“…59 Although the oral phase is rather short (1-2 min), the duration of the gastric phase (1.5-2 h) ensures the solubilization of a significant amount of carotenoids with the aid of co-consumed dietary lipids, being mainly incorporated into comparably large lipid globules unless efficient emulsifiers have been co-consumed as well. 60 Once in the small intestine, secreted bile salts and highly efficient lipases help to break down and reduce the size of these globules to ultimately form small mixed micelles, which are considered as the most important transport vehicle of carotenoids for absorption. 61 These newly formed mixed micelles consist of a plethora of amphiphilic and hydrophobic compounds derived from the secretion of human bile or ingested food.…”

Section: Liberation Micellization and Intestinal Absorptionmentioning

confidence: 99%

“…First models aiming at the improvements of carotenoid ester cleavage have emerged recently. 60,88 The background of such further improvements is discussed below.…”

Section: In Vitro Digestion Modelsmentioning

confidence: 99%

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Bioaccessibility of carotenoids from plant and animal foods

2019

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The frequent consumption of carotenoid‐rich foods has been associated with numerous health benefits, such as the supply of provitamin A. To exert these health benefits, carotenoids need to be efficiently liberated from the food matrix, micellized in the small intestine, taken up by the enterocytes and absorbed into the human blood stream. Enormous efforts have been made to better understand these processes. Because human studies are costly, labor‐intense and time‐consuming, the evaluation of carotenoid liberation and micellization at the laboratory scale using simulated in vitro digestion models has proven to be an important tool for obtaining preliminary results prior to conducting human studies. In particular, the liberation from the food matrix and the intestinal micellization can be mimicked by simulated digestion, yielding an estimate of the so‐called bioaccessibility of a carotenoid. In the present review, we provide an overview of the carotenoid digestion process in vivo, the currently used in vitro digestion models and the outcomes of previous bioaccessibility studies, with a special focus on correlations with concomitantly conducted human studies. Furthermore, we advocate for the on‐going requirement of better standardized digestion protocols and, in addition, we provide suggestions for the complementation of the acquired knowledge and current nutritional recommendations. © 2018 Society of Chemical Industry

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Section: In Vitro Digestion Modelsmentioning

confidence: 99%

Section: Factors Affecting Carotenoid Bioaccessibilitymentioning

confidence: 99%

“…As a result of low cleavage turnovers, Wen et al . aimed to identify approaches that increased the efficiency, considering the example of the commonly poorly cleaved zeaxanthin diesters.…”

Section: Factors Affecting Carotenoid Bioaccessibilitymentioning

confidence: 99%

Section: Liberation Micellization and Intestinal Absorptionmentioning

confidence: 99%

“…First models aiming at the improvements of carotenoid ester cleavage have emerged recently. 60,88 The background of such further improvements is discussed below.…”

Section: In Vitro Digestion Modelsmentioning

confidence: 99%

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Bioaccessibility of carotenoids from plant and animal foods

2019

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In vitro bioaccessibility of macular xanthophylls from commercial microalgal powders of Arthrospira platensis and Chlorella pyrenoidosa

Tudor

Gherasim

Dulf

et al. 2021

Food Science & Nutrition

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The bioaccessibility of the major carotenoids present in two commercial microalgal supplements in powder form was investigated through a standardized in vitro digestion method. The dried biomass of Arthrospira platensis contained β‐carotene (36.8 mg/100 g) and zeaxanthin (20.8 mg/100 g) as the main carotenoids as well as a high content of saturated fatty acids (61% of total fatty acids), whereas that of Chlorella pyrenoidosa was rich in lutein (37.8 mg/100 g) and had a high level of unsaturated fatty acids (65% of total fatty acids). In the case of the latter, lutein bioaccessibility was not statistically enhanced after the replacement of porcine bile extract with bovine bile extract in the in vitro digestion protocol and after the addition of coconut oil (17.8% as against to 19.2% and 19.2% vs. 18.5%, respectively). In contrast, the use of bovine bile extract along with co‐digestion with coconut oil significantly enhanced the bioaccessibility of zeaxanthin from A. platensis, reaching the highest bioaccessibility of 42.8%.

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Analysis of the pesticide behavior in Chaenomelis speciosa and the role of digestive enzyme in vitro oral bioaccessibility

Xiao

Zhuang

et al. 2019

Chemosphere

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Screening of critical factors influencing the efficient hydrolysis of zeaxanthin dipalmitate in an adapted in vitro- digestion model

Cited by 22 publications

References 46 publications

Bioaccessibility of carotenoids from plant and animal foods

Bioaccessibility of carotenoids from plant and animal foods

In vitro bioaccessibility of macular xanthophylls from commercial microalgal powders of Arthrospira platensis and Chlorella pyrenoidosa

Analysis of the pesticide behavior in Chaenomelis speciosa and the role of digestive enzyme in vitro oral bioaccessibility

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