Screening of congenital hypothyroidism in preterm, low birth weight and very low birth weight neonates: A systematic review

Hashemipour, Mahin; Hovsepian, Silva; Ansari, Arman; Keikha, Mojtaba; Khalighinejad, Pooyan; Niknam, Negar

doi:10.1016/j.pedneo.2017.04.006

Cited by 79 publications

(69 citation statements)

References 41 publications

(44 reference statements)

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“…CH and, in particular, mild CH are more common in some risk categories such as preterm or ill neonates [12], small for gestational age infants [13], children born after in vitro fertilization (IVF) [14], and in multiple pregnancies [15]. In these categories of neonates, the initial screening tests may be inappropriate or provide normal results, and therefore the European Society for Pediatric Endocrinologist (ESPE) guidelines [2] suggest a strategy of second screening, at about 2 weeks of age or 2 weeks after the first screening test.…”

Section: Mild Hypothyroidism In Neonatesmentioning

confidence: 99%

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Mild Hypothyroidism in Childhood: Who, When, and How Should Be Treated?

Vigone

Capalbo

Weber

et al. 2018

Journal of the Endocrine Society

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Mild hypothyroidism, also known as subclinical hypothyroidism (SH), is biochemically defined as serum TSH levels above the upper limit of the reference range, in the presence of normal serum concentrations of total T4 and free T4 (FT4). In the neonatal period, mild hypothyroidism can be defined by the presence of a TSH value between 6 and 20 mIU/L and normal FT4 levels. After the neonatal period, SH can be defined mild if TSH ranges between 4.5 and 10 mIU/L. The management of mild hypothyroidism in childhood is challenging. The major concern is to establish whether this condition should always be considered an expression of mild thyroid dysfunction. Indeed, the effects of untreated mild hypothyroidism are still not completely defined. In the neonatal period, concern exists about neurocognitive outcome; in children, although there is no clear evidence of alterations in growth or neurocognitive development, subtle cardiovascular abnormalities have been documented. Therefore, there is still uncertainty about the need of treatment across all ages, and the management should be based on the age of the child, the etiology, and the degree of TSH elevation, as well as on other patient factors. This review updates current evidences on diagnosis and management of mild hypothyroidism in childhood.

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Section: Mild Hypothyroidism In Neonatesmentioning

confidence: 99%

“…In a recent systematic review, Hashemipour et al [12] recommend repeating the screening test in preterm, LBW, and VLBW infants at the age of 2, 6, and 10 weeks by measuring TSH and FT4 levels simultaneously and considering TSH of 10 mIU/L as the cutoff level for positive and suspicious cases.…”

Section: Mild Hypothyroidism In Neonatesmentioning

confidence: 99%

Mild Hypothyroidism in Childhood: Who, When, and How Should Be Treated?

Vigone

Capalbo

Weber

et al. 2018

Journal of the Endocrine Society

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“…Opinions vary regarding the recommended rescreening time for TFT, and these variances can range between 2 and 6 weeks after birth 14,3537) . Hashemipour et al 37) reviewed documentation on the screening process of preterm congenital hypothyroidism and suggested that repeated screening is necessary. A TSH level of 10 mU/L was defined as the positive cutoff level; a TSH level of 10 to…”

Section: Risk Factorsmentioning

confidence: 99%

Risk Factors for Delayed Hyperthyrotropinemia in Late Preterm Infants

Jeong¹,

Lee²,

Bae³

et al. 2019

Neonatal Med

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Purpose: This study aimed to investigate the prevalence of delayed thyroid dysfunc tion based on iodine disinfectant use and to analyze associated risk factors. Methods: A retrospective study was conducted on late preterm infants admitted to the neonatal intensive care unit between January 2010 and June 2018, who under went neonatal thyroid screening (NTS) and ≥2 thyroid function tests (TFTs). NTS was performed 3 days after birth, with at least two TFTs 1 week and 2 to 4 weeks after birth. To distinguish between normal and dysfunctional thyroid levels, we reviewed TFT results at 2 to 4 weeks and examined possible risk factors for the development of thyroid dysfunction. Results: Of 295 late preterm infants, 262 were enrolled with a mean gestational age and birth weight of 34.8±0.7 weeks and 2,170±454 g, respectively. A total of 7.6% de veloped hyperthyrotropinemia at the age of 24.3±14.6 days (range, 12 to 69). The in cidence of hyperthyrotropinemia during iodine use was approximately 12.6%, while that during discontinuation was 2.4% (P=0.002). Multivariate analysis revealed that small for gestational age (SGA), iodine disinfectant use, and abnormal NTS results were significant risk factors for delayed hyperthyrotropinemia (adjusted odds ratio [

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“…Ayrıca, RDS olan hastalarda daha prematüre olmalarından dolayı solunum destek süresi de uzun bulunmuştur (19). Çalışmamızda daha prematüre bebeklerde doğum sonrası TSH yüksekliği ile daha düşük sT4 düzeyi ve RDS oranı prematüreliğin getirdiği bir sonuçtur (8,20,21).…”

Section: Introductionunclassified

Investigation of The Relationship Between Congenital Hypothyroidism and Respiratory Distress Syndrome in Very Low Birth Weight Newborns

Çakır¹,

Tayman²,

Bekmez³

et al. 2020

atfm

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Objectives: Respiratory distress syndrome (RDS) is associated with severe morbidity and mortality, which occurs due to surfactant deficiency in the lung. In the present study, we aimed to determine the risk factors for RDS and the effect of congenital hypothyroidism (CH) on RDS in very low birth weight (VLBW<1500 g) infants. Materials and Methods: The study was completed between January 2013 and August 2017. Data of eligible infants were obtained from hospital medical records. Patients were divided in to groups with and without CH, and those with and without RDS according to requirement of surfactant therapy. Results: Six hundred and seventy patients of 729 patients (gestational age: 27.5±1.3 weeks, birth weight: 1014±219 g) were included in the study, and thyroid function test results were obtained on day 5 th respiratory distress syndrome ratio was 71.4% (n=20) in the CH group (n=28) and 61.3% (n=394) in the non-CH group (n=642). Respiratory distress syndrome ratio (71.4%) was found to be statistically higher in CH group than those in non-CH group (61.3%) (p=0.000). The frequency of CH (5.3% vs 2.3%, p=0.015, respectively) was higher in patients with RDS. RDS ratio in those with CH and CHD in those with RDS were found to be higher. Conclusion: Based on these findings, it is thought that thyroid hormones may affect lung development and dynamics.

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Screening of congenital hypothyroidism in preterm, low birth weight and very low birth weight neonates: A systematic review

Cited by 79 publications

References 41 publications

Mild Hypothyroidism in Childhood: Who, When, and How Should Be Treated?

Mild Hypothyroidism in Childhood: Who, When, and How Should Be Treated?

Risk Factors for Delayed Hyperthyrotropinemia in Late Preterm Infants

Investigation of The Relationship Between Congenital Hypothyroidism and Respiratory Distress Syndrome in Very Low Birth Weight Newborns

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