Screening of chemical composition, anti-arthritis, antitumor and antioxidant capacities of essential oils from four Zingiberaceae herbs

Zhang, Lanyue; Liang, Xinmiao; Ou, Zhirong; Ye, Mao; Shi, Yaohui; Chen, Yubin; Zheng, Dan; Xiang, Hongping

doi:10.1016/j.indcrop.2020.112342

Cited by 51 publications

(37 citation statements)

References 35 publications

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“…Many herbs from this family have found applications in various industries (food, cosmetics, perfumery, pharmacy, etc.) due to their characteristic organoleptic properties (color, taste, odor) and their diverse chemical composition [ 2 ]. Indeed, Zingiberaceae species are a rich source of various phytochemicals, from alkaloids, carbohydrates, proteins, phenolic acids, flavonoids, and diarylheptanoids [ 3 , 4 ].…”

Section: Introductionmentioning

confidence: 99%

“…In general, it can be stated that the antioxidant and pharmaceutical properties of Zingiberaceae plants are related to their chemical composition; this is primarily due to the presence of phenolic compounds and other biologically active constituents. Various extraction methods have already been evaluated for the isolation and purification of different bioactive compound classes from ginger spices, including classical hydrodistillation [ 2 , 5 , 28 , 29 ], extractions with supercritical fluids (supercritical CO 2 , supercritical water) [ 22 , 30 , 31 ], ultrasound-assisted extraction [ 32 , 33 ], and microwave-assisted extraction [ 34 ]. Gas chromatography-mass spectrometry (GC-MS) is a commonly used method for chemical characterization of EOs [ 1 , 29 , 32 , 35 , 36 ].…”

Section: Introductionmentioning

confidence: 99%

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Comparative Study of Chemical Composition and Antioxidant Activity of Essential Oils and Crude Extracts of Four Characteristic Zingiberaceae Herbs

Ivanović

Makoter

Razboršek

2021

Plants

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The ginger family (Zingiberaceae) includes plants that are known worldwide to have a distinctive smell and taste, which are often used as spices in the kitchen, but also in various industries (pharmaceutical, medical, and cosmetic) due to their proven biological activity. The aim of this study was to investigate and compare the chemical composition and antioxidant activity (AA) of essential oils (EOs) of four characteristic ginger species: Elettaria cardamomum L. Maton (cardamom), Curcuma Longa L. (turmeric), Zingiber Officinale Roscoe (ginger), and Alpinia Officinarum Hance (galangal). Furthermore, the total phenolic content (TPC) and AA of crude extracts obtained after using ultrasound-assisted extraction (UAE) and different extraction solvents (80% ethanol, 80% methanol and water) were evaluated. A total of 87 different chemical components were determined by GC-MS/MS in the EOs obtained after hydrodistillation, 14 of which were identified in varying amounts in all EOs. The major compounds found in cardamom, turmeric, ginger, and galangal were α-terpinyl acetate (40.70%), β-turmerone (25.77%), α-zingiberene (22.69%) and 1,8-cineol (42.71%), respectively. In general, 80% ethanol was found to be the most effective extracting solvent for the bioactivities of the investigated species from the Zingiberaceae family. Among the crude extracts, ethanolic extract of galangal showed the highest TPC value (63.01 ± 1.06 mg GA g−1 DW), while the lowest TPC content was found in cardamom water extract (1.04 ± 0.29 mg GA g−1 DW). The AA evaluated by two different assays (ferric-reducing antioxidant power-FRAP and the scavenging activity of the cationic ABTS radical) proved that galangal rhizome is the plant with the highest antioxidant potential. In addition, no statistical difference was found between the AA of turmeric and ginger extracts, while cardamom rhizome was again inferior. In contrast to the crude extracts, the EOs resulted in significantly lower ABTS and FRAP values, with turmeric EO showing the highest AA.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Comparative Study of Chemical Composition and Antioxidant Activity of Essential Oils and Crude Extracts of Four Characteristic Zingiberaceae Herbs

Ivanović

Makoter

Razboršek

2021

Plants

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“…Zhang and coworkers recently evaluated the antiarthritic potential of Zingiberaceae plant EOs, including Alpinia galanga (L.) Willd., Alpinia oxyphylla Miq., Amomum kravanh Pierre ex Gagnep., and Kaempferia galanga L. [ 52 ]. These species were demonstrated to down-regulate the expression levels of COX-2, TNF-α, IL-6, and IL-1 in Freund’s adjuvant-induced arthritic rats, with K. galanga being the most effective one.…”

Section: Essential Oils With Antiarthritic Potentialmentioning

confidence: 99%

“…Such effects were also demonstrated for Litsea cubeba , whose EO was able to decrease the TNF-α, IL-1β, IL-6, IL-8, and IL-17A levels and to increase IL-10 in type II collagen-induced arthritic rats [ 40 ]. K. galanga and some other species belonging to the Zingiberaceae family also demonstrated impacts on the expression of COX-2, TNF-α, IL-6, and IL-1 in Freund’s adjuvant-induced arthritic rats [ 52 ]. The levels of TNF-α and IL-1β and the activity of MMPs in the synovial fluid were also reduced by an ointment containing essential oils from 16 species, among which were E. caryophyllata , C. inophyllum , C. aurantium , and E. globulus , as described by Komeh-Nkrumah and coworkers [ 53 ].…”

Section: Mechanisms Of Actionmentioning

confidence: 99%

Essential Oils and Bioactive Components against Arthritis: A Novel Perspective on Their Therapeutic Potential

Marrelli

Amodeo

Perri

et al. 2020

Plants

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Essential oils (EOs) are known to possess a number of beneficial properties. Their antimicrobial, anti-inflammatory, antioxidant, antidiabetic, and cancer-preventing activities have been extensively reported. Due to their wide use as food preservers and additives, as well as their use in agriculture, perfumes, and make-up products, these complex mixtures of volatile compounds have gained importance from a commercial point of view, not only in the pharmaceutical industry, but also in agronomic, food, cosmetic, and perfume industries. An analysis of the recent scientific literature allowed us to highlight the presence of an increasing number of studies on the potential antiarthritic properties of EOs and their main constituents, which seems to suggest a new interesting potential therapeutic application. The aim of this review is to examine the current knowledge on the beneficial effects of essential oils in the treatment of arthritic diseases, providing an overview of the reports on the in vivo and in vitro effects of EOs. Furthermore, this review critically examines the recent findings on the potential roles of the main components of EOs in the exerted beneficial effects. Obtained negative results are also reported.

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“…In fact, EOs extracted by steam distillation of many aromatic plants have recently received a lot of attention due to their broad spectrum of action. These natural ingredients, composed of complex mixtures of monoterpenes, biogenetically related phenols, and sesquiterpenes [17][18][19], display antibacterial, antiviral, and antifungal activities, in addition to insecticide properties, as already mentioned [19][20][21][22][23][24]. Owing to their wide spectrum of activity, these compounds are nowadays considered as an alternative to chemicals in many applications, such as food preservation, pharmaceuticals, alternative medicine, and natural therapies [25][26][27].…”

Section: Introductionmentioning

confidence: 99%

New Eugenol Derivatives with Enhanced Insecticidal Activity

Fernandes

Pereira

et al. 2020

IJMS

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Eugenol, the generic name of 4-allyl-2-methoxyphenol, is the major component of clove essential oil, and has demonstrated relevant biological potential with well-known antimicrobial and antioxidant actions. New O-alkylated eugenol derivatives, bearing a propyl chain with terminals like hydrogen, hydroxyl, ester, chlorine, and carboxylic acid, were synthesized in the present work. These compounds were later subjected to epoxidation conditions to give the corresponding oxiranes. All derivatives were evaluated against their effect upon the viability of insect cell line Sf9 (Spodoptera frugiperda), demonstrating that structural changes elicit marked effects in terms of potency. In addition, the most promising molecules were evaluated for their impact in cell morphology, caspase-like activity, and potential toxicity towards human cells. Some molecules stood out in terms of toxicity towards insect cells, with morphological assessment of treated cells showing chromatin condensation and fragmentation, which are compatible with the occurrence of programmed cell death, later confirmed by evaluation of caspase-like activity. These findings point out the potential use of eugenol derivatives as semisynthetic insecticides from plant natural products.

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Screening of chemical composition, anti-arthritis, antitumor and antioxidant capacities of essential oils from four Zingiberaceae herbs

Cited by 51 publications

References 35 publications

Comparative Study of Chemical Composition and Antioxidant Activity of Essential Oils and Crude Extracts of Four Characteristic Zingiberaceae Herbs

Comparative Study of Chemical Composition and Antioxidant Activity of Essential Oils and Crude Extracts of Four Characteristic Zingiberaceae Herbs

Essential Oils and Bioactive Components against Arthritis: A Novel Perspective on Their Therapeutic Potential

New Eugenol Derivatives with Enhanced Insecticidal Activity

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