Screening of Biomarkers Related to Myocardial Infarction Based on the Construction of a ceRNA Regulation Network

Ma, Pingwei; Li, Jianfeng; Cheng, Ming

doi:10.14744/anatoljcardiol.2023.2388

Cited by 2 publications

(1 citation statement)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Very little information is available from any previous studies of the long noncoding RNA RP3-375P9.2, apart from an association in a hepatocellular carcinoma (HCC) genomic and epigenomics study within early- and late-stage patients 32 . The RP3-375P9.2 lncRNA does not appear to be associated with MI in a recent pathway-based study 33 .…”

Section: Discussionmentioning

confidence: 82%

Uncovering myocardial infarction genetic signatures using GWAS exploration in Saudi and European cohorts

Al-Ali,

Al-Rubaish,

Alali

et al. 2023

Sci Rep

View full text Add to dashboard Cite

Genome-wide association studies (GWAS) have yielded significant insights into the genetic architecture of myocardial infarction (MI), although studies in non-European populations are still lacking. Saudi Arabian cohorts offer an opportunity to discover novel genetic variants impacting disease risk due to a high rate of consanguinity. Genome-wide genotyping (GWG), imputation and GWAS followed by meta-analysis were performed based on two independent Saudi Arabian studies comprising 3950 MI patients and 2324 non-MI controls. Meta-analyses were then performed with these two Saudi MI studies and the CardioGRAMplusC4D and UK BioBank GWAS as controls. Meta-analyses of the two Saudi MI studies resulted in 17 SNPs with genome-wide significance. Meta-analyses of all 4 studies revealed 66 loci with genome-wide significance levels of p < 5 × 10–8. All of these variants, except rs2764203, have previously been reported as MI-associated loci or to have high linkage disequilibrium with known loci. One SNP association in Shisa family member 5 (SHISA5) (rs11707229) was evident at a much higher frequency in the Saudi MI populations (> 12% MAF). In conclusion, our results replicated many MI associations, whereas in Saudi-only GWAS (meta-analyses), several new loci were implicated that require future validation and functional analyses.

show abstract

Section: Discussionmentioning

confidence: 82%

Uncovering myocardial infarction genetic signatures using GWAS exploration in Saudi and European cohorts

Al-Ali,

Al-Rubaish,

Alali

et al. 2023

Sci Rep

View full text Add to dashboard Cite

show abstract

GWAS in two Saudi Myocardial Infarction Cohorts and European based studies reveal dozens of concordant signals

Al-Ali

Al-Rubaish

Alali

et al. 2023

Preprint

View full text Add to dashboard Cite

Genome-wide association studies (GWAS) have yielded significant insights into the genetic architecture of MI although studies in non-European are still lacking. Saudi Arabian cohorts offers the opportunity for discovery of novel genetic variants impacting disease risk due to the high rate of consanguinity. GWG imputation and GWAS followed by meta-analysis was performed on two independent Saudi Arabian studies comprising 3,950 MI cases and 2,324 non-MI controls. Meta-analyses were then performed with the two Saudi MI studies and the CardioGRAMplusC4D and the UK BioBank GWAS as controls Meta-analyses of the two Saudi MI studies resulted in 17 SNPs reaching genome-wide significance. Meta-analyses of all 4 studies revealed 66 loci reaching genome-wide significance levels of p < 5 x 10− 8. All of these variants with the exception of rs2764203 have previously been reported as MI associated loci or are in high linkage disequilibrium with known loci. One SNP association in Shisa family member 5 (SHISA5) (rs11707229), is evident at a much higher frequency in Saudi MI populations (> 12% MAF). In conclusion, our results replicated many MI associations, whereas in Saudi only GWAS (meta-analyses) several new loci were implicated that would require future studies for validation and functional analyses.

show abstract

Screening of Biomarkers Related to Myocardial Infarction Based on the Construction of a ceRNA Regulation Network

Cited by 2 publications

References 28 publications

Uncovering myocardial infarction genetic signatures using GWAS exploration in Saudi and European cohorts

Uncovering myocardial infarction genetic signatures using GWAS exploration in Saudi and European cohorts

GWAS in two Saudi Myocardial Infarction Cohorts and European based studies reveal dozens of concordant signals

Contact Info

Product

Resources

About