Screening of Australian medicinal plants for antiviral activity

Semple, Susan J.; Reynolds, Geoffrey D.; O'Leary, Martin; Flower, Robert L.

doi:10.1016/s0378-8741(97)00152-9

Cited by 113 publications

(83 citation statements)

References 28 publications

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“…According to Semple et al (1998Semple et al ( ,1999, Pterocaulon sphacelatum has antiviral activity suggesting that other species from Pterocaulon genus may also have antiviral activity. Coumarins have been related to HIV-1 protease inhibitory activity (Kirkiacharian et al, 2002).…”

Section: Resultsmentioning

confidence: 99%

“…Twelve species belonging to Pterocaulon genus have previously been mentioned as medicinal (Maes et al, 2006). Studies concerning pharmacological activities report antiviral activity against poliovirus and rhinovirus (Semple et al, 1998(Semple et al, , 1999, antibacterial activity (Macleod and Rasmussen, 1999), DNA interaction and anti-tumor activities (Mongelli et al, 2000), anti-proliferative and differentiating properties on human leukemia cells (Riveiro et al, 2004) and antifungal activity (Stein et al, 2005). The main class of active coumponds found in Pterocaulon genus are terpenes, flavonoids and coumarins (Bohlmann et al, 1981;Debenedetti et al, 1997Debenedetti et al, , 1999Macleod and Rasmussen, 1999;Riveiro et al, 2004;Semple et al, 1999;Vera et al, 2001;Vilegas et al, 1995).…”

Section: Introductionmentioning

confidence: 99%

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In vitro cytotoxic, antioxidant and antiviral effects of Pterocaulon alopecuroides and Bidens segetum extracts

Silveira¹,

Martins²,

Costa³

et al. 2009

Rev. bras. farmacogn.

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RESUMO: "Efeitos citotóxico, antioxidante e antiviral in vitro de extratos de Pterocaulon alopecuroides e Bidens segetum". Pterocaulon alopecuroides (Lamark) De Candolle e Bidens segetum Mart. ex Colla são duas espécies pertencentes à família Asteraceae. Os extratos dessas duas espécies foram avaliados quanto às suas atividades citotóxica, antioxidante e antiviral. Todos os extratos analisados apresentaram citotoxidade muito alta contra linhagens de células RBL-2H3. O ensaio de atividade antioxidante demonstrou uma alta atividade das frações em acetato de etila de B. segetum e P. alopecuroides. Isso pode ser parcialmente explicado pelo alto conteúdo de cumarinas, ao menos para P. alopecuroides. Nenhum dos extratos etanólicos totais de B. segetum mostraram atividade significativa contra o vírus Herpes simplex (Tipos 1 e 2 resistentes ao aciclovir). O extrato etanólico de P. alopecuroides também foi inativo contra o vírus Herpes simplex tipo 1 resistente ao aciclovir. Entretanto, este extrato apresentou atividade inibitória contra o vírus Herpes simplex tipo 2 resistente ao aciclovir. Do extrato etanólico bruto de P. alopecuroides foi possível isolar a 7-(2',3'-dihidroxi-3'-metilbutiloxi)-6-metoxicumarina, a qual foi testada nas mesmas condições, demonstrando um índice de inibição viral quase duas vezes maior do que o da amostra de P. alopecuroides para HSV-2-ACVr. A cumarina tabém foi ativa contra HSV-1-ACVr. Esses resultados evidenciam a importância de Pterocaulon alopecuroides e Bidens segetum como plantas medicinais.Unitermos: Pterocaulon alopecuroides, Bidens segetum, atividade antiviral, atividade citotóxica, atividade antioxidante, 7-(2',3'-dihidroxi-3'-metilbutiloxi)-6-metoxicumarina. ABSTRACT:Pterocaulon alopecuroides (Lamark) De Candolle and Bidens segetum Mart. ex Colla are two species belonging to the Asteraceae family. Extracts from those two species were evaluated to their cytotoxic, antioxidant and antiviral activities. All the extracts assayed have shown a very high cytotoxity against RBL-2H3 cell line. The antioxidant assay pointed out a really high activity of the ethyl acetate extracts for B. segetum and P. alopecuroides. This can be partially explained due to the high content of coumarins, at least for P. alopecuroides. None of the total ethanol extracts from B. segetum showed significant activity against the two strains of Herpes simplex virus (Types 1 and 2 resistant to acyclovir). P. alopecuroides ethanol extract was also inactive against the Herpes simplex virus type 1 resistant to acyclovir. However, this extract presented inhibitory activity against the Herpes simplex virus type 2 resistant to acyclovir. From the ethanol crude extract of P. alopecuroides, it was possible to isolate 7-(2',3'-dihidroxy-3'-methylbutyloxy)-6-methoxycoumarin, which was tested in the same conditions, showing a viral inhibitory rate almost twice bigger than the P. alopecuroides sample for HSV-2-ACVr. The coumarin was also active against HSV-1-ACVr. Those results provide further evidence of the importance of Pter...

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

In vitro cytotoxic, antioxidant and antiviral effects of Pterocaulon alopecuroides and Bidens segetum extracts

Silveira¹,

Martins²,

Costa³

et al. 2009

Rev. bras. farmacogn.

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“…This group has also demonstrated the antiviral activity of the same Australian plants (Semple et al, 1998). There are many other Australian plants, some used by Australian Aboriginals, that have not as yet been properly examined for antibacterial activity.…”

Section: Much Of the Information About The Antimicrobial Activities Omentioning

confidence: 97%

Antibacterial Activity of Selected Australian Native Plant Extracts

2008

IJMB

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“…In this manner, plants extracts with phyto-chemical have been obtaine more critical as potential source for viral inhibitors amid the late decade. Broad studies have demonstrated that therapeutic plants of a few parts of the world contain compounds dynamic against infections that bring about human diseases [5,6,7]. In the conventional medication system, parts of this plant are utilized for the treatment of different human ailments.…”

Section: Introductionmentioning

confidence: 99%

Antibacterial Evaluation of Nerium Oleander Extract Enhanced by Titanium Oxide Nanoparticles

Makia¹

2017

JNUS

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The antimicrobial activities of ethanolic extract of the Nerium oleander have been screened by anti-bacterial action against Staphylococcus aureus, Klebsiella pneumonie and Escherichia coli utilizing the disc diffusion test. An endeavor was additionally made to enhanced the antimicrobial activity of the ethanolic extract of Nerium oleander by blending of TiO 2 nanoparticles with Nerium oleander extract. In view of the general results, the ethanolic extract of Nerium oleander enhanced by TiO 2 Nps demonstrated the most activities against a wide range of tested bacteria, yet the ethanolic extract alone was observed to be dynamic against the S. aureus and E. coli, while a powerless antibacterial activity was observed against the ethanolic extract demonstrate a K. pneumonie. Inhibition efficiency increased with increasing concentration of the ethanolic extract of and also with enhanced by TiO 2 Nps. The inhibition zone at the concentration 300 mg/mL in presence and absence of TiO 2 NPs were 21 mm and 24 mm against Staphylococcus aureus and against Klebsiella pneumonie were 12 mm and 25 mm, finally for Escherichia coli were 23 mm and 29 mm respectively.

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Screening of Australian medicinal plants for antiviral activity

Cited by 113 publications

References 28 publications

In vitro cytotoxic, antioxidant and antiviral effects of Pterocaulon alopecuroides and Bidens segetum extracts

In vitro cytotoxic, antioxidant and antiviral effects of Pterocaulon alopecuroides and Bidens segetum extracts

Antibacterial Activity of Selected Australian Native Plant Extracts

Antibacterial Evaluation of Nerium Oleander Extract Enhanced by Titanium Oxide Nanoparticles

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