Screening of antiplasmodial properties among some traditionally used Iranian plants

Esmaeili, Somayeh; Naghibi, Farzaneh; Mosaddegh, Mahmoud; Sahranavard, Shamim; Ghafari, Saeedeh; Abdullah, Noor Rain

doi:10.1016/j.jep.2008.10.041

Cited by 58 publications

(30 citation statements)

References 9 publications

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“…The results of ethnopharmacological investigations of local hakeems and healers show that the plants of the genus Perovskia are used as antiinflammatory, fortifier, antiseptic, leishmaniasis, anthelmintic, antimalarial, and for rheumatic pains (Ballabh et al, 2008;Esmaeili et al, 2008;Baquar, 1989;Hosseinzadeh & Amel, 2001;Moallem & Niapour, 2008;Nassiri et al, 2002). Previous phytochmical investigation on the plant Perovskia atriplicifolia showed phenolic and flavonoidal constituents (Perveen & Malik, 2006.…”

Section: Introductionmentioning

confidence: 99%

Anti-inflammatory constituents fromPerovskia atriplicifolia

Ahmad

Waheed

Tahir

et al. 2015

Pharmaceutical Biology

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Context: Perovskia atriplicifolia Benth (Labiantae) has long been used as a traditional herbal medicine for anti-inflammation in Pakistan; this prompted us to isolate anti-inflammatory compounds from this plant. Objective: The objective of this study was to isolate and characterize the anti-inflammatory principles from Perovskia atriplicifolia. Materials and methods: The CHCl 3 -soluble fraction of the methanol extract of the whole plant on column chromatography yielded compounds 1-6. The anti-inflammatory potential of the compounds 1-6 was evaluated by Leukotriene C4 (LTC 4 ) Release Assay which was performed according to the established protocol. LTC 4 in the supernatant of each well was measured using an ELISA kit (Cayman Chemical Co., Ann Arbor, MI). Results: The bioassay-guided phytochemical investigation of the CHCl 3 soluble fraction of the methanol extract of Perovskia atriplicifolia furnished six compounds, abrotanone (1), abrotandiol (2), (+)-pinoresinol (3), (+)-syringaresinol (4), (+)-lariciresinol (5), and (+)-taxiresinol (6). The compounds (1-6) were evaluated for their inhibitory activities on LTC 4 release. Among the tested compounds, (+)-taxiresinol (6) exhibited the most potent inhibition of LTC 4 release with an IC 50 value of 3.4 ± 0.09 mM followed by compounds 4, 5, 3, and 2 with an IC 50 value ranging from 7.9 ± 0.04 to 17.2 ± 0.07 mM. Abrotanone (1) showed the lowest inhibition of LTC 4 release with an IC 50 value of 35.1 ± 0.05 mM (the positive control, zileuton, 0.77 ± 0.05 mM). Conclusion: Compounds 1-6 were found to possess inhibitory activity and seem to have potential therapeutic effect on inflammatory diseases.

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Section: Introductionmentioning

confidence: 99%

Anti-inflammatory constituents fromPerovskia atriplicifolia

Ahmad

Waheed

Tahir

et al. 2015

Pharmaceutical Biology

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“…Although many Buxus plants have documented ethnomedicinal uses for the treatment of malaria [3,4], and some plant extracts of in this genus have also been reported to show antimalarial activities in in vitro and/or in vivo studies [24,25], the chemical types of the active principles that are responsible for the antiplasmodial effects are incompletely understood. As the major constituents of boxwood species, Buxus alkaloids have been proposed as the most likely active constituents for the antimalarial activity ascribed to these plants.…”

Section: Resultsmentioning

confidence: 99%

New bioactive lupane triterpene coumaroyl esters isolated from Buxus cochinchinensis

Pan¹,

Acuña²,

Chai³

et al. 2014

Planta Med

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Five new lupane triterpene coumaroyl esters (1-5), together with betulin (6) and a known Buxus alkaloid, N-3-benzoyldihydrocyclomicrophylline F (7), were isolated from a CHCl 3 -soluble partition of a methanol extract of Buxus cochinchinensis Pierre ex Gagnep. (Buxaceae) collected in Vietnam. Isolation work was monitored using human colon cancer cells . The structures of the new compounds (1-5) were determined on the basis of spectroscopic data interpretation. In addition to their cytotoxicity against HT-29 cells and NF-κB (p65) inhibitory activity in an ELISA assay, all isolates, as well as two semi-synthetic compounds derived from betulin and 5, respectively, were also evaluated for their in vitro antiplasmodial activities against the drugresistant Dd2 strain of Plasmodium falciparum and antifungal effects on the growth of the pathogenic yeast Candida albicans. The new lupane triterpene coumaroyl esters (1-5), along with Conflict of InterestThe authors declare no conflict of interest. HHS Public Access

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“…Penelitian terhadap aktifitas antimalaria beberapa tanaman dari keempat familia tersebut juga telah dilakukan sebelumnya, seperti Psidium guajava (IC50 10-20 µg/ml), Syzigium aromaticum (IC50 6,25 µg/ml) dari familia Myrtaceae, Ardisia crispa (IC50 5,9 µg/ml), Maesa lanceolata (IC50 1,6 µg/ml) dari familia Myrsinaceae, Physalis angulata (IC50 1,27 µg/ml), Acnistus arborescens (IC50 1,3 µg/ml) dari familia Solanaceae dan Glycyrrhiza glabra (IC50 17,5 µg/ml), Pterocarpus erinaceus (IC50 1,27 µg/ml) dari familia Fabaceae memiliki potensi aktivitas antimalaria yang baik. Aktivitas antimalaria dari tanaman-tanaman tersebut diduga disebabkan oleh adanya kandungan alkaloid, antrakuinon, flavonoid, dan terpenoid (Titanji et al, 2008;Katuura et al, 2007;Begum dan Goyal, 2007;Bagavan et al, 2010;Noor Rain et al, 2007;Lusakibanza et al, 2010;Garavito et al, 2006;Karou et al, 2003;Esmaeili et al, 2008).…”

Section: Pendahuluanunclassified

Skrining Aktivitas Antimalaria Beberapa Tanaman Indonesia Hasil Eksplorasi Dari Hutan Raya Cangar, Batu-Malang, Jawa Timur

Hafid

Puliansari

Lestari

et al. 2017

JFIKI

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AbstrakLatar Belakang: Malaria adalah penyakit yang tergolong penting yang pengendaliannya bergantung pada kemoterapi yang spesifik, dan kondisinya menjadi lebih sulit dengan adanya resistensi Plasmodium falciparum terhadap obat antimalaria yang tersedia. Kondisi ini memicu kebutuhan terhadap alternatif terapi antimalaria. Tujuan: Tujuan dari penelitian ini adalah untuk menentukan kandidat antimalaria baru dari beberapa tanaman Indonesia yang dikoleksi dari Hutan Raya Cangar, Batu-Malang, Jawa Timur. Metode: Sebelas sampel dari ekstrak daun dan batang diuji pada kultur Plasmodium falciparum strain 3D7 yang dikembangkan dalam media RPMI-1640. Sampel diuji pada konsentrasi 0,01; 0,1; 1; 10 dan 100 µg/ml. Analisis probit digunakan untuk menentukan nilai IC50. Hasil: Uji aktivitas malaria in vitro menunjukkan bahwa terdapat tiga sampel dari ekstrak batang Fraxinus griffithi, ekstrak daun Piper sulcatum dan ekstrak batang Eucalyptus globulus mempunyai aktivitas antimalaria yang baik dengan nilai IC50 berturut-turut 0,33; 0,20; dan 0,55 µg/ml. Kesimpulan: Ekstrak batang Fraxinus griffithi, ekstrak daun Piper sulcatum dan ekstrak batang Eucalyptus globulus bisa menjadi kandidat yang baik sebagai sumber bahan obat antimalaria. Kata kunci: aktivitas antimalaria, in vitro, plasmodium falciparum, ekstrak tanaman

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Screening of antiplasmodial properties among some traditionally used Iranian plants

Cited by 58 publications

References 9 publications

Anti-inflammatory constituents fromPerovskia atriplicifolia

Anti-inflammatory constituents fromPerovskia atriplicifolia

New bioactive lupane triterpene coumaroyl esters isolated from Buxus cochinchinensis

Skrining Aktivitas Antimalaria Beberapa Tanaman Indonesia Hasil Eksplorasi Dari Hutan Raya Cangar, Batu-Malang, Jawa Timur

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