Screening of Analgesic Activity and Adverse Effects of Bisthiazolidine in Male Albino Rats

Abstract

Introduction: This study was carried out to screen the analgesic efficacy and adverse effects of bisthiazolidines in male albino rats. Materials & Methods: The study was conducted using male Albino rats (130-175gm.) housed in polypropylene cages. The animals were divided into 5 groups (n=6) each receiving different treatments. Both central visceral and peripheral somatic pain were screened using radiant heat method, hot plate method and writhing test. The first group of animals was taken as control, the second group was given the reference standard drug and the other groups received bisthiazolidines at different doses. For sub-acute toxicity study, bisthiazolidines was given per orally (P.O) daily for 14 days at the dose level of 75 mg/kg. Biochemical analysis of blood and histopathological study of GI mucosa was done after 14 days. Results: Bisthiazolidines showed significant analgesia compared to control. The results were significant (p<0.05) in radiant heat method and also in hot plate method (p<0.05) at the dose of 75 mg/kg. Writhing test showed highly significant result with maximum inhibition (51.17%) at the dose of 75 mg/kg. No significant adverse effects on renal and hepatic functions were found with bisthiazolidine. Histopathological study of GI mucosa showed preservation of normal architecture with bisthiazolidine. Conclusion: Bisthiazolidine showed significant peripheral somatic analgesia and also proved to be safe in respect of the renal and hepatic functions along with no adverse effects on GI mucosa.

Management of Ankyloglossia with different severity: a case series in dental surgery

“…Ankyloglossia is a rare congenital disorder caused by cellular degeneration failure, resulting in a long anchorage between the tongue and the floor of the mouth. 11 Although most patients with ankyloglossia do not have other congenital abnormalities, ankyloglossia may be associated with a number of syndromes, including Beckwith-Wiedemann syndrome, Van der Woude syndrome, Ehler Danlos syndrome, and others. 13 Until now there is still a debate about the most optimal diagnostic criteria and therapy of ankyloglossia.…”

“…Children with ankyloglossia may experience problems such as malnutrition, difficulty in swallowing, speech difficulties, and mandibular prognathism. [9][10][11] There are numerous surgery and therapeutic options for cases of ankyloglossia depending on its severity. [12][13][14][15] In this article, a series of three cases of ankyloglossia will be presented in different ages of patient (6 months, 3 years and 6 years old), which aim to provide a specific description of the case ankyloglossia and guidelines that must be considered before treatment in case ankyloglossia.…”