Screening of a Novel Upregulated lncRNA, A2M-AS1, That Promotes Invasion and Migration and Signifies Poor Prognosis in Breast Cancer

Fang, Kai; Hu, Chen; Zhang, Xiufen; Guo, Zijian; Li, Lihua

doi:10.1155/2020/9747826

Cited by 15 publications

(16 citation statements)

References 35 publications

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“…Three lncRNAs ( A2M-AS1 , C2orf27A , and ZNF667-AS1 ) were identified to be related to the hub FRGs. Among them, A2M-AS1 was reported to be involved in the invasion, migration, and progression of breast cancer ( Fang et al, 2020 ; Liu et al, 2020b ). In addition, A2M-AS1 was also reported to lessen cardiomyocyte injury caused by hypoxia/reoxygenation (H/R) by regulating IL1R2 ( Song et al, 2020 ).…”

Section: Discussionmentioning

confidence: 99%

LncRNAs Target Ferroptosis-Related Genes and Impair Activation of CD4+ T Cell in Gastric Cancer

Yao

et al. 2021

Front. Cell Dev. Biol.

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Gastric cancer (GC) is a malignant disease of the digestive tract and a life-threatening disease worldwide. Ferroptosis, an iron-dependent cell death caused by lipid peroxidation, is reported to be highly correlated with gastric tumorigenesis and immune cell activity. However, the underlying relationship between ferroptosis and the tumor microenvironment in GC and potential intervention strategies have not been unveiled. In this study, we profiled the transcriptome and prognosis data of ferroptosis-related genes (FRGs) in GC samples of the TCGA-STAD dataset. The infiltrating immune cells in GC were estimated using the CIBERSORT and XCELL algorithms. We found that the high expression of the hub FRGs (MYB, PSAT1, TP53, and LONP1) was positively correlated with poor overall survival in GC patients. The results were validated in an external GC cohort (GSE62254). Further immune cell infiltration analysis revealed that CD4+ T cells were the major infiltrated cells in the tumor microenvironment of GC. Moreover, the hub FRGs were significantly positively correlated with activated CD4+ T cell infiltration, especially Th cells. The gene features in the high-FRG score group were enriched in cell division, DNA repair, protein folding, T cell receptor, Wnt and NIK/NF-kappaB signaling pathways, indicating that the hub FRGs may mediate CD4+ T cell activation by these pathways. In addition, an upstream transcriptional regulation network of the hub FRGs by lncRNAs was also developed. Three lncRNAs (A2M-AS1, C2orf27A, and ZNF667-AS1) were identified to be related to the expression of the hub FRGs. Collectively, these results showed that lncRNA A2M-AS1, C2orf27A, and ZNF667-AS1 may target the hub FRGs and impair CD4+ T cell activation, which finally leads to poor prognosis of GC. Effective interventions for the above lncRNAs and the hub FRGs can help promote CD4+ T cell activation in GC patients and improve the efficacy of immunotherapy. These findings provide a novel idea of GC immunotherapy and hold promise for future clinical application.

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Section: Discussionmentioning

confidence: 99%

LncRNAs Target Ferroptosis-Related Genes and Impair Activation of CD4+ T Cell in Gastric Cancer

Yao

et al. 2021

Front. Cell Dev. Biol.

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“…45 Upregulated A2M‐AS1 was associated with invasion and migration in breast cancer. 46 Besides, LINC00702 enhanced the progression of ovarian cancer through increased EZH2 expression. 47 Then, LINC00702/has‐miR‐4652‐3p/ZEBI axis can promote the progression of malignant meningioma through activating the Wnt/β‐catenin pathway.…”

Section: Discussionmentioning

confidence: 99%

Identification of lncRNA‐associated competing endogenous RNA networks for occurrence and prognosis of gastric carcinoma

Jin

2021

Clinical Laboratory Analysis

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Gastric cancer (GC) is one of the most frequent digestive system cancers and is the second cause of cancer mortality worldwide by 2018. 1 The cases in China account for more than 40% of the total number of GC worldwide due to a high incidence rate and a large population. 2 Moreover, the GC patients were more likely to be in the advanced stage when diagnosed because of non-early specific symptoms.Unfortunately, the late diagnosis can significantly affect the 5-year survival rate. In the past decade, due to the advancement of treatment and medicine, the GC prognosis has improved, but it is still not satisfied due to the relatively short disease-free survival duration. 3 Thus, it is challenging and necessary to explore the underlying mechanisms of GC and identify novel biomarkers or treatment targets.

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“…LncRNA A2M-AS1 is demonstrated to influence the progression of pancreatic cancer. 6 Interestingly, Fang et al have elucidated that lncRNA A2M-AS1 was also enriched in BC, which facilitated BC cell proliferation, invasion, and migration, 7 while the roles of lncRNA A2M-AS1 in BC remain to be further explored. Following the evaluation of the functional relevance of lncRNA A2M-AS1 to BC cell function, this study demonstrated that lncRNA A2M-AS1 regulated BC cell biological activity by sponging miR-146b.…”

Section: Discussionmentioning

confidence: 99%

“… 6 Furthermore, A2M-AS1 elevation has been suggested to be related to poor recurrence-free and metastasis-free survival of BC patients, implying its possible prognostic and therapeutic role in BC. 7 However, whether A2M-AS1 indeed modulates the progression of BC and how the mechanism works remain unsettled. LncRNAs act as competing endogenous RNAs (ceRNAs) by competitively interacting with shared microRNAs (miRNAs).…”

Section: Introductionmentioning

confidence: 99%

<p>Long Non-Coding RNA A2M-AS1 Promotes Breast Cancer Progression by Sponging microRNA-146b to Upregulate MUC19</p>

Liu¹,

Zhang²,

Wu³

et al. 2020

IJGM

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Background: Long non-coding RNA (lncRNA) A2M-AS1 has been indicated to be augmented in breast cancer (BC), with its specific function undetermined. Therefore, this study is designed to investigate the mechanism of lncRNA A2M-AS1 in BC. Methods: The expression of A2M-AS1, microRNA (miR)-146b, and MUC19 in BC tissues and cells was measured. Then, the interaction among A2M-AS1, miR-146b, and MUC19 was detected. After A2M-AS1, miR-146b, and MUC19 expression were altered in BC cells, cell proliferation, invasion, and apoptosis were detected, and the protein levels of Hipporelated proteins (YAP and p-YAP) were evaluated. Tumor growth assay was also performed to validate the effects of A2M-AS1 and miR-146b in vivo. Results: A2M-AS1 and MUC19 were highly expressed in BC, while miR-146b was poorly expressed. A2M-AS1 acts as a molecular sponge for miR-146b, which targeted and negatively modulated MUC19. A2M-AS1 accelerated BC cell proliferation, invasion, and colony formation and suppressed apoptosis via the miR-146b/MUC19/Hippo axis, which was confirmed in vivo. Conclusion: Taken above together, an oncogenic role for A2M-AS1 in BC was elicited by acting as a miR-146b sponge to promote MUC19 expression. The findings will present some cues for a further approach to BC.

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Screening of a Novel Upregulated lncRNA, A2M-AS1, That Promotes Invasion and Migration and Signifies Poor Prognosis in Breast Cancer

Cited by 15 publications

References 35 publications

LncRNAs Target Ferroptosis-Related Genes and Impair Activation of CD4+ T Cell in Gastric Cancer

LncRNAs Target Ferroptosis-Related Genes and Impair Activation of CD4+ T Cell in Gastric Cancer

Identification of lncRNA‐associated competing endogenous RNA networks for occurrence and prognosis of gastric carcinoma

<p>Long Non-Coding RNA A2M-AS1 Promotes Breast Cancer Progression by Sponging microRNA-146b to Upregulate MUC19</p>

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