Screening medicinal plant extracts for xanthine oxidase inhibitory activity

Ha, Ahmed; Nguyen, Ch. D.P.; Le, Tan Minh

doi:10.32362/2410-6593-2022-17-2-131-139

Cited by 7 publications

(1 citation statement)

References 27 publications

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“…Piper betle L. belonging to the family Piperaceae, native to Southeast Asia, was found to have the most potential ability to inhibit xanthine oxidase with an IC50 value of up to 1.18 μg/mL, compared to allopurinol 1.57 μg/mL. Various parts of Piper betle L. were compared and the leaves of P. betle L. showed the best value for XO inhibitory and antioxidant activity compared to the whole plant, and the stem extract (Ha et al, 2022).…”

Section: Introductionmentioning

confidence: 99%

Herbal remedies in the management of hyperuricemia and gout: A review of in vitro, in vivo and clinical evidences

Mahomoodally,

Coodian,

Hosenally

et al. 2024

Phytotherapy Research

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Gout, or hyperuricemia is a multifactorial and multi‐faceted metabolic disease that is quite difficult to manage and/or treat. Conventional therapies such as non‐steroidal anti‐inflammatory drugs (NSAIDs) such as allopurinol, corticosteroids and colchicine amongst others, have helped in its management and treatment to some extent. This study aimed to compile and analyze the different herbal remedies used in the management of hyperuricemia and gout. A literature search was conducted from key databases (PubMed, ScienceDirect, Cochrane Library, Google Scholar) using relevant keywords via the PRISMA model. Smilax riparia A.DC. from Traditional Chinese Medicine is used in many countries for its therapeutic effect on lowering serum urate levels. No single study was able to establish the efficacy of a specific traditionally used herb via in vitro, in vivo, and clinical studies. Patients were found to use a panoply of natural remedies, mainly plants to treat hyperuricemia and gout, which have been validated to some extent by in vitro, in vivo, and clinical studies. Nonetheless, further research is needed to better understand the ethnopharmacological relationship of such herbal remedies.

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Section: Introductionmentioning

confidence: 99%