Screening inventories to detect depression in chronic hepatitis C patients

Fábregas, Bruno Cópio; Vitorino, Flávia Domingues; Rocha, Débora Millard; Moura, Alexandre Sampaio; Carmo, Ricardo Andrade; Teixeira, Antônio Lúcio

doi:10.1016/j.genhosppsych.2011.09.002

Cited by 18 publications

(9 citation statements)

References 25 publications

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“…The novel data presented herein are part of a larger project that involved thorough psychiatric and psychopathological evaluation of CHC patients [6,17,18]. All individuals included in the study were anti-HCV antibody positive determined by third-generation enzyme-linked immunosorbent assay (ELISA) for more than 6 months with serum HCV RNA detectable by polymerase chain reaction (AMPLICOR; Roche Molecular Systems).…”

Section: Methodsmentioning

confidence: 99%

“…The BDI is a self-rating scale with 21 items, including somatic and nonsomatic symptoms. It is the most frequently used self-rating depression scale, both in clinical practice and in research settings, and is regarded as the most efficient inventory to screen for depression in HCV patients [17]. Symptoms of anxiety were quantified using the Hamilton Anxiety Rating Scale (HAM-A) [25] and the HAD [23].…”

Section: Methodsmentioning

confidence: 99%

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A Follow-Up Study of 50 Chronic Hepatitis C Patients: Adiponectin as a Resilience Biomarker for Major Depression

Fábregas

Vieira

Moura

et al. 2016

Neuroimmunomodulation

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Objective: Major depression (MD) is a condition associated with both hepatitis C virus (HCV) infection and pegylated interferon (IFN)-α treatment. IFN induces a depressive syndrome that is associated with an inflammatory profile. We aimed to investigate whether there is any specific alteration in plasma biomarkers associated with MD. Methods: HCV-monoinfected patients, with and without IFN treatment, were followed up for 18 months and went through structured psychiatric evaluation. We assessed plasma levels of brain-derived neurotrophic factor, tumor necrosis factor (TNF) and its soluble type 1 and type 2 receptors (sTNFR1 and sTNFR2, respectively), and adipokines (adiponectin, leptin and resistin) using ELISA. Results: Among the 50 patients included in the study, 14 were treated with IFN during the follow-up. Being older, not married, presenting higher body mass index, higher liver inflammatory activity, lower baseline adiponectin levels and use of IFN were associated with MD development. Higher levels of sTNFR1 during IFN treatment were associated with sustained virological response. The lack of a control group without HCV infection did not allow any assumption of a biomarker change exclusively due to the infection itself. Conclusion: Adiponectin may be a resilience biomarker for MD in HCV-infected patients.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

A Follow-Up Study of 50 Chronic Hepatitis C Patients: Adiponectin as a Resilience Biomarker for Major Depression

Fábregas

Vieira

Moura

et al. 2016

Neuroimmunomodulation

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“…The long-term exposure to cytokines may be associated with the onset of depression. The best studied example comprises patients receiving IFN-α to treat melanoma and hepatitis C virus infection 32 . In experimental animals, the administration of cytokines, such as IL-6, or cytokine inducers, such as lipopolysaccharide (LPS), have been found to induce depressive-like behaviors 33 .…”

Section: Pathophysiologymentioning

confidence: 99%

Post stroke depression: clinics, etiopathogenesis and therapeutics

Pedroso¹,

Souza²,

Brunoni³

et al. 2015

Arch. Clin. Psychiatry (São Saulo)

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Background: Stroke is a major cause of morbidity and mortality worldwide. Neuropsychiatric disorders are often associated with stroke and, among them, depression is the most prevalent. Post-stroke Depression (PSD) is related to disability, failure in returning to work, impairment in interpersonal functioning and mortality. Its etiopathogenesis is still uncertain, as well as its treatment. In Brazil, there are few data on the impact of PSD. Objective: This work is dedicated to conduct a comprehensive review of the concept of PSD, its pathophysiology, morbidity and treatment. Methods: PubMed, Medline and Lilacs searches of relevant terms yielded 3,265 papers in the last 10 years. We selected original studies and reviews that addressed the aspects mentioned above. Results: We present the history of the notion of PSD and describe its epidemiology, looking to highlight Brazilian studies. Diagnostic criteria and clinical presentation were detailed, with emphasis on cognitive aspects. The four main pathophysiological theories proposed to PSD are presented and we discuss the various treatment strategies, involving psychopharmacologic options, brain stimulation techniques and psychotherapy. Discussion: This work provides comprehensive information on PSD, of great utility for clinical practice and research in this topic.

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“…The cutoff points suggested by Kendall et al 23 for undiagnosed samples were selected, and scores above 15 and 20 points indicated depressive symptoms and depression, respectively. Of note, the BDI can be used for screening depressive symptoms in the HCV population due to its good discriminative properties 24 .…”

Section: Instrumentsmentioning

confidence: 99%

Depressive symptoms and harmful alcohol use in hepatitis C patients: prevalence and correlates

Machado

Silva

Torres

et al. 2014

Rev. Soc. Bras. Med. Trop.

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Introduction:It is important to understand the characteristics and vulnerabilities of people who have hepatitis C because this disease is currently an important public health problem. The objective of this study was to estimate the prevalence of depressive symptoms and harmful alcohol use in patients with hepatitis C and to study the association between these outcomes and demographic, psychosocial and clinical variables. Methods: This cross-sectional, descriptive and analytical study involved 82 hepatitis C patients who were being treated with pegylated interferon and ribavirin at a public university hospital. The primary assessments used in the study were the Alcohol Use Disorders Identifi cation Test and the Beck Depression Inventory. Bivariate analyses were followed by logistic regression. Results: The prevalence of depressive symptoms was 30.5% (n=25), and that of harmful alcohol use was 34.2% (n=28). Logistic regression analysis showed that individuals who were dissatisfi ed with their social support (OR=4.41; CI=1.00-19.33) and were unemployed (OR=6.31; CI=1.44-27.70) were at a higher risk for depressive symptoms, whereas harmful alcohol use was associated with the male sex (OR=6.78; CI=1. 38-33.19) and the use of illicit substances (OR=7.42; CI=1.12-49.00). Conclusions: High prevalence rates of depressive symptoms and harmful alcohol use were verifi ed, indicating vulnerabilities that must be properly monitored and treated to reduce emotional suffering in this population.

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Screening inventories to detect depression in chronic hepatitis C patients

Cited by 18 publications

References 25 publications

A Follow-Up Study of 50 Chronic Hepatitis C Patients: Adiponectin as a Resilience Biomarker for Major Depression

A Follow-Up Study of 50 Chronic Hepatitis C Patients: Adiponectin as a Resilience Biomarker for Major Depression

Post stroke depression: clinics, etiopathogenesis and therapeutics

Depressive symptoms and harmful alcohol use in hepatitis C patients: prevalence and correlates

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