“…Highly accurate methods for the detection of SA, which is highly specific for HT1, exist and have been incorporated into universal NBS programmes in both high and low incidence areas and could be incorporated into UK NBS practice 19–21. The incidence of HT1 in the UK is approximately 1 in 100 000 live births, but is higher in some areas such as the West Midlands 22. Our data, and that of others, have shown that pre-emptive treatment is effective in preventing liver disease and will decrease the risk of HCC and prevents a small number of liver transplants annually.…”