Screening for two SNPs of LINGO1 gene in patients with essential tremor or sporadic Parkinson's disease in Chinese population

Zuo, Xing; Jiang, Hong; Guo, Jifeng; Yu, Renhe; Sun, Qiying; Hu, Liang; Wang, Lei; Yao, Lingyan; Shen, Lu; Pan, Qian; Yan, Xinxiang; Xia, Kun; Tang, Beisha

doi:10.1016/j.neulet.2010.06.041

Cited by 37 publications

(27 citation statements)

References 24 publications

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“…Our result, that allele ''T'' of LINGO1 rs11856808 decreased the risk for PD, is consistent with an Italian study [2], but is in contrast to the result from North American and Spanish studies, which found that rs11856808 increased the risk for PD [19]. Other studies on Chinese [31], German [14], and Austrian [10] populations did not find significant correlations between the rs11856808 polymorphism and the risk for PD. However, our meta-analysis found that the rs11856808 decreased the risk of PD in an Asian population, which was inconsistent with a previous meta-analysis, which found a lack of association between rs11856808 in LINGO1 and PD [1].…”

Section: Discussionsupporting

confidence: 85%

“…However, other studies from North America [26] and Italy [2] obtained the opposite results and showed that these two polymorphisms decreased the risk for PD. In Asian, a Chinese study found that only the rs9652490 ''G'' allele may have a protective role in the early onset PD, but did not find a significant association between rs11856808 and the risk of PD [31]. However, other studies, including Austrian, Polish, Germany, North American and Chinese populations, did not find rs9652490 correlated with the risk for PD [3,9,10,14,29].…”

Section: Introductionmentioning

confidence: 94%

“…Given that its expression is restricted to neuronal tissue [11], and its high degree of homology with LINGO1 (61 %), LINGO2 may have a similar function to LINGO1 [21]. Therefore, considering that LINGO1 and LINGO2 may be involved in the pathogenesis of PD, many studies have investigated the associations between the variants of the two genes and the risk of PD [2,3,9,10,14,19,[23][24][25][26][29][30][31]. However, the results are not completely consistent with each other.…”

Section: Introductionmentioning

confidence: 99%

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Analysis and meta-analysis of five polymorphisms of the LINGO1 and LINGO2 genes in Parkinson’s disease and multiple system atrophy in a Chinese population

et al. 2015

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Whether polymorphisms rs11856808 and rs9652490 of the Leucine-rich repeat and Ig domain containing, Nogo receptor-interacting protein-1 (LINGO1) gene, as well as rs10968280, rs13362909 and rs7033345 of the LINGO2 gene, increase the risk for Parkinson's disease (PD) is controversial. Considering the overlap of the clinical and pathological characteristics among PD and multiple system atrophy (MSA), we explored the associations between these five polymorphisms and PD and MSA in a Chinese population. A total of 1055 PD patients, 320 MSA patients, and 810 healthy controls (HCs) were genotyped for these five polymorphisms in LINGO1 and LINGO 2 using Sequenom iPLEX Assay technology. Moreover, after combining our results with available published data, a meta-analysis was conducted to investigate the associations between LINGO 1 rs11856808 and rs9652490 and the risk of PD. The frequency of the minor alleles "T" of LINGO1 rs11856808 was significantly lower in PD than that in HCs (p = 0.011, OR 0.89, 95 % CI 0.81-0.97), but not in MSA. Moreover, there were no significant differences in the minor allele frequency distributions of the other four polymorphisms between PD and HCs, and between MSA and HCs. The meta-analysis showed a lack of association of rs9652490 and PD, regardless of the genetic model or ethnic origin. However, the rs11856808 allele decreased the risk of PD in patients of Asian origin in a dominant genetic model. Our findings suggest that rs11856808 plays a protective role by decreasing the risk for PD, but not for MSA, in Asian population, the other four polymorphisms do not contribute to the risk for PD and MSA.

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Section: Discussionsupporting

confidence: 85%

Section: Introductionmentioning

confidence: 94%

Section: Introductionmentioning

confidence: 99%

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Analysis and meta-analysis of five polymorphisms of the LINGO1 and LINGO2 genes in Parkinson’s disease and multiple system atrophy in a Chinese population

et al. 2015

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“…Zuo et al [17] reported lack of association between LINGO1 rs9652490 and rs11856808 genotypes and allelic variants in a sample of Chinese subjects. A similar finding was reported by our group in Spanish patients with familial ET compared with controls [19], by Bourassa et al [20] in a French-Canadian population, and Radovica et al [21] in a Latvian population.…”

Section: Discussionmentioning

confidence: 99%

“…Since then, 5 studies found association between rs9652490 polymorphism and ET [12][13][14][15][16], while other 5 studies failed to confirm this association [17][18][19][20][21]. Regarding rs11856808 polymorphism and risk for ET, Thier et al [14] confirmed the association, while other 5 groups found absence of association [16,17,[19][20][21].…”

Section: Introductionmentioning

confidence: 99%

LINGO1 and risk for essential tremor: Results of a meta-analysis of rs9652490 and rs11856808

Jiménez‐Jiménez

García‐Martín

Lorenzo‐Betancor

et al. 2012

Journal of the Neurological Sciences

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Increased LINGO1 in the cerebellum of essential tremor patients

et al. 2014

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Essential tremor (ET) is the most prevalent adult-onset movement disorder. Despite its health burden, no clear pathognomonic sign has been identified to date because of the rarity of clinicopathological studies. Moreover, treatment options are still scarce and have not significantly changed in the last 30 years, underscoring the urgent need to develop new treatment avenues. In the recent years, leucine-rich repeat (LRR) and immunoglobulin (Ig) domain-containing Nogo receptor-interacting proteins 1 and 2 (LINGO1 and LINGO2, respectively) have been increasingly regarded as possible ET modulators due to emerging genetic association studies linking LINGO with ET. We have investigated LINGO protein and messenger RNA (mRNA) expression in the cerebellum of patients with ET, patients with Parkinson's disease (PD), and a control group using Western immunoblotting and in situ hybridization. Protein levels of LINGO1, but not LINGO2, were significantly increased in the cerebellar cortex of ET patients compared with controls, particularly in individuals with longer disease duration. Compared with controls, LINGO1 protein levels were increased in the cerebellar white matter of PD and ET patients but, for the latter, only when disease duration exceeded 20 years. However, no alteration in LINGO1 mRNA was observed between groups in either the cerebellar cortex or the white matter. We observed alterations in LINGO expression in diseased brain that seemed to progress along with the disease, being initiated in the cerebellar cortex before reaching the white matter. Because LINGO up-regulation has been identified as a potential pathological response to ongoing neurodegenerative processes, the present data suggest that LINGO1 is a potential drug target for ET.

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Screening for two SNPs of LINGO1 gene in patients with essential tremor or sporadic Parkinson's disease in Chinese population

Cited by 37 publications

References 24 publications

Analysis and meta-analysis of five polymorphisms of the LINGO1 and LINGO2 genes in Parkinson’s disease and multiple system atrophy in a Chinese population

Analysis and meta-analysis of five polymorphisms of the LINGO1 and LINGO2 genes in Parkinson’s disease and multiple system atrophy in a Chinese population

LINGO1 and risk for essential tremor: Results of a meta-analysis of rs9652490 and rs11856808

Increased LINGO1 in the cerebellum of essential tremor patients

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