Screening for Stroke in Sickle Cell Anemia: Comparison of Transcranial Doppler Imaging and Nonimaging US Techniques

Neish, Ariane Staub; Blews, David E.; Simms, Catherine A; Merritt, Robert; Spinks, Alice J

doi:10.1148/radiol.2223010524

Cited by 43 publications

(45 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These children were screened by TCD imaging (TCDI) 3,[5][6][7] since the age of 12 to 18 months and had a history of abnormal TCDI defined by TAMMV $200 cm/s and at least 1 year of follow-up with TCDI. Hemoglobin levels were measured the same day as the TCDI assessment.…”

Section: Methodsmentioning

confidence: 99%

Long-term treatment follow-up of children with sickle cell disease monitored with abnormal transcranial Doppler velocities

Bernaudin

Verlhac

Arnaud

et al. 2016

Blood

View full text Add to dashboard Cite

show abstract

Section: Methodsmentioning

confidence: 99%

Long-term treatment follow-up of children with sickle cell disease monitored with abnormal transcranial Doppler velocities

Bernaudin

Verlhac

Arnaud

et al. 2016

Blood

View full text Add to dashboard Cite

show abstract

“…Previous evaluation of TCD imaging versus TCD scanning had shown that both methods gave similar results when used according to strict, established protocols. 10 Extracranial carotid and vertebral arteries were routinely scanned during the examination. Although this did not form part of the scanning protocol in the STOP trial when non-imaging TCD was used, it has been used routinely in our center to provide additional information on the cerebral circulation.…”

Section: Doppler Measurementsmentioning

confidence: 99%

Extracranial internal carotid arterial disease in children with sickle cell anemia

et al. 2010

View full text Add to dashboard Cite

BackgroundSickle cell anemia is one of the commonest causes of stroke in children. It is usually, but not always, associated with intracranial vasculopathy. We have assessed the value of ultrasound screening for extracranial internal carotid artery disease. Design and MethodsUsing Doppler ultrasound scanning, we assessed peak systolic blood velocity, tortuosity and stenosis in the extracranial internal carotid arteries of 236 children with sickle cell anemia. Seventeen of the children had previously had a stroke. All measurements were performed as part of routine clinical care. ResultsThe median extracranial internal carotid artery velocity was 148cm/s (5 th centile 84, 95 th centile 236). Higher velocities were significantly correlated with younger age, higher white blood cell counts and higher rates of hemolysis. Fourteen (5.9%) had tortuous extracranial internal carotid arteries and 13 (5.4%) had stenosis or occlusion. None of the children with tortuous vessels but 8 of those with stenosis had previously had a stroke; the presence of stenosis was strongly associated with overt clinical stroke (OR 35.9, 95% C.I. 9.77-132, P<0.001). In 6 children, extracranial stenosis was part of extensive intracranial vasculopathy, but in 2 there was no evidence of intracranial disease. Stenosis seemed to be more common in older children. ConclusionsExtracranial internal carotid artery stenosis is strongly associated with stroke in children with sickle cell anemia, and may explain some cases of stroke without overt intracranial vasculopathy. Doppler ultrasound scanning of extracranial internal carotid arteries is non-invasive and fairly quick to perform and may identify children at increased risk of stroke who would otherwise be missed. The value of extracranial internal carotid artery scanning should be studied prospectively.Key words: sickle cell anemia, internal carotid artery, Doppler ultrasound scanning.Citation: Deane CR, Goss D, Bartram J, Pohl KRE, Height SE, Sibtain N, Jarosz J, Thein SL, and Rees DC. Extracranial internal carotid arterial disease in children with sickle cell anemia. Haematologica 2010;95(8):1287-1292. doi:10.3324/haematol.2010 This is an open-access paper. Extracranial internal carotid arterial disease in children with sickle cell anemia

show abstract

“…Moreover, no significant difference was found in a recent report comparing both methods. 3 Thus, the study by Rees et al may have included patients with only marginally abnormal velocities. In addition, if these patients were transfused early, it could have influenced the occurrence of vasculopathy.…”

Section: G6pd Deficiency and Cerebrovascular Disease In Sickle Cell Amentioning

confidence: 99%

“…Proportions of immature CD19 ؉ CD21 ؊ B lymphocytes predict the response to extracorporeal photopheresis in patients with chronic graft-versus-host disease B lymphocytes are increasingly assigned an important role in the pathogenesis of auto-and alloimmune diseases including chronic graft-versus-host disease (cGVHD) [1][2][3][4] where abnormalities of Bcell homeostasis in patients with active cGVHD have been observed. 1,4 Extracorporeal photopheresis (ECP) achieves high response rates in steroid-refractory cGVHD.…”

Section: To the Editormentioning

confidence: 99%

See 1 more Smart Citation

Response: G6PD deficiency and cerebrovascular disease in sickle cell anemia?

Bernaudin

Verlhac

Torrès

2009

Blood

View full text Add to dashboard Cite

Screening for Stroke in Sickle Cell Anemia: Comparison of Transcranial Doppler Imaging and Nonimaging US Techniques

Abstract: V(mean) measurements in the middle cerebral artery, distal internal carotid artery, and anterior cerebral artery did not vary substantially between nonimaging and imaging transcranial Doppler US. RI data did not yield comparable measurements.

Cited by 43 publications

References 11 publications

Long-term treatment follow-up of children with sickle cell disease monitored with abnormal transcranial Doppler velocities

Long-term treatment follow-up of children with sickle cell disease monitored with abnormal transcranial Doppler velocities

Extracranial internal carotid arterial disease in children with sickle cell anemia

Response: G6PD deficiency and cerebrovascular disease in sickle cell anemia?

Contact Info

Product

Resources

About