Screening for REM sleep behavior disorder in the general population

Bušková, Jitka; Ibarburu, Veronika; Šonka, Karel; Růžička, Evžen

doi:10.1016/j.sleep.2016.07.003

Cited by 31 publications

(21 citation statements)

References 4 publications

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“…Note that this may change if additional high‐LR markers could be added to the MDS prodromal criteria. A recent study of objectively measured orthostatic hypotension suggested potential LR of 8.3, and two studies of RBD diagnosed by expert interview alone suggested a potential LR of 50 …”

Section: Discussionmentioning

confidence: 99%

Validation of the MDS research criteria for prodromal Parkinson's disease: Longitudinal assessment in a REM sleep behavior disorder (RBD) cohort

et al. 2017

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The prodromal criteria are a promising tool for predicting incidence of PD/dementia with Lewy bodies and conversion time in a rapid eye movement sleep behavior disorder cohort, with high sensitivity and high specificity with long follow-up. Prodromal markers influence the overall likelihood ratio independently, allowing them to be reliably multiplied. Defining additional markers with high likelihood ratio, further studies with longitudinal assessment and testing thresholds in different target populations will improve the criteria. © 2017 International Parkinson and Movement Disorder Society.

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Section: Discussionmentioning

confidence: 99%

Validation of the MDS research criteria for prodromal Parkinson's disease: Longitudinal assessment in a REM sleep behavior disorder (RBD) cohort

et al. 2017

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“…Therefore, questionnaire-based diagnosis of RBD is insufficient and should be considered as probable only, with necessity of further PSG confirmation. More effective strategies for identification of RBD subjects in large populations may be based on multistep screening approaches ( 138 , 139 ), using single screening questions, followed by one of the specific RBD rating scales and a more detailed sleep interview. Also, while there is no solid evidence on use of wearable technologies such as smartphones and smartwatch in screening for RBD, with advancing technologies it is likely these may become a reasonable first line screening option for RBD in the future and thus should be explored in more details.…”

Section: Discussionmentioning

confidence: 99%

Accuracy of Rating Scales and Clinical Measures for Screening of Rapid Eye Movement Sleep Behavior Disorder and for Predicting Conversion to Parkinson’s Disease and Other Synucleinopathies

et al. 2018

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Rapid eye movement (REM) sleep behavior disorder (RBD) is characterized by repeated episodes of REM sleep-related vocalizations and/or complex motor behaviors. Definite diagnosis of RBD is based on history and polysomnography, both of which are less accessible due to the lack of trained specialists and high cost. While RBD may be associated with disorders like narcolepsy, focal brain lesions, and encephalitis, idiopathic RBD (iRBD) may convert to Parkinson’s disease (PD) and other synucleinopathies in more than 80% of patients and it is to date the most specific clinical prodromal marker of PD. Identification of individuals at high risk for development of PD is becoming one of the most important topics for current PD-related research as well as for future treatment trials targeting prodromal PD. Furthermore, concomitant clinical symptoms, such as subtle motor impairment, hyposmia, autonomic dysfunction, or cognitive difficulties, in subjects with iRBD may herald its phenoconversion to clinically manifest parkinsonism. The assessment of these motor and non-motor symptoms in iRBD may increase the sensitivity and specificity in identifying prodromal PD subjects. This review evaluates the diagnostic accuracy of individual rating scales and validated single items for screening of RBD and the role and accuracy of available clinical, electrophysiological, imaging, and tissue biomarkers in predicting the phenoconversion from iRBD to clinically manifest synucleinopathies.

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“…Patients were screened in a stepwise manner following a public advertisement and internet survey [14]; RBD was dia gnosed in accordance with the International Classifi cation of Sleep Disorders, third edition [15]. Exclusion criteria were: overt parkinsonism (dia gnosed according to the Movement Disorder Society [MDS] criteria [16]) or dementia (dia gnosed according to the Dia gnostic and Statistical Manual of Mental Disorders [17]), severe obstructive sleep apnea defi ned by the Apnea-Hypopnea Index (AHI) ≥ 30, and the presence of other disorders that could cause secondary RBD (for example, narcolepsy or lesions in the brainstem on brain MRI).…”

Section: Methodsmentioning

confidence: 99%

Olfactory dysfunction in a cohort of Czech patients with idiopathic REM sleep behaviour diorder

́Antonia¹,

Dušek²,

Tesař³

et al. 2019

Cesk Slov Neurol N

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Aim: Rapid eye movement (REM) sleep behaviour disorder (RBD) is a sleep abnormality heralded by the absence of physiological atonia in REM sleep and dream enactment behaviour. Idiopathic RBD (iRBD), dia g nosed when no primary RBD cause can be identified, is a marker of prodromal synucleinopathy with a high conversion rate to overt neurodegenerative disorders from the synucleinopathy group. The aim of this cross-sectional study was to investigate olfactory function in iRBD patients and its relation to other symptoms. Patients and methods: This study included 54 iRBD patients with a median age of 67 (IQR 63-72) years; the 37 control subjects, matched by gender and age, had a median age of 67 (57.5-70.0) years. All subjects underwent a complex examination, which included olfactory testing using the University of Pennsylvania Smell Identifi cation Test (UPSIT). Results: In total, 62.9% of iRBD patients had either total loss of olfactory function or severe hyposmia. In contrast, only 8.1% of controls showed such a degree of olfactory dysfunction. Furthermore, we found that the percentage of REM sleep without atonia on polysomnography negatively correlates with the UPSIT score (P < 0.01). Conclusion: This study demonstrated a signifi cantly lower olfactory function in the iRBD group compared to controls. Souhrn Cíl: Porucha chování v REM (rapid eye movement) spánku (REM sleep behavior disorder; RBD) je parasomnie charakterizovaná nepřítomností fyziologické atonie a chováním uskutečňování snu v REM spánku. Jako idiopatická RBD (iRBD) je RBD označena v nepřítomnosti jiné nemoci, která RBD obvykle vyvolává. Idiopatická RBD je známkou prodromální fáze synukleinopatie a má vysokou míru fenokonverze do neurodegenerativních nemocí ze skupiny synukleinopatií. Cílem této průřezové studie bylo zjistit stav čichové funkce u pacientů s iRBD a její vztah k jiným symptomům. Materiál a metody: Do studie bylo zahrnuto 54 pacientů s iRBD s mediánem věku 67 (IQR 63-72) let a 37 kontrolních subjektů s mediánem věku 67 (57,5-70,0) let, které byly spárovány podle věku a pohlaví. Všichni účastníci studie absolvovali komplexní vyšetření, které obsahovalo Identifi kační čichový test Pensylvánské univerzity (University of Pennsylvania Identifaction Test; UPSIT). Výsledky: Úplnou ztrátu čichu anebo jeho těžkou dysfunkci mělo 62,9 % pacientů s iRBD, přitom u kontrolních subjektů to bylo pouze 8,1 %. Porucha atonie v REM spánku v polysomnografi i nepřímo korelovala se skóre UPSIT (p < 0,01). Závěr: Studie prokázala významně horší čich u pacientů s iRBD než u kontrolních osob.

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Screening for REM sleep behavior disorder in the general population

Cited by 31 publications

References 4 publications

Validation of the MDS research criteria for prodromal Parkinson's disease: Longitudinal assessment in a REM sleep behavior disorder (RBD) cohort

Validation of the MDS research criteria for prodromal Parkinson's disease: Longitudinal assessment in a REM sleep behavior disorder (RBD) cohort

Accuracy of Rating Scales and Clinical Measures for Screening of Rapid Eye Movement Sleep Behavior Disorder and for Predicting Conversion to Parkinson’s Disease and Other Synucleinopathies

Olfactory dysfunction in a cohort of Czech patients with idiopathic REM sleep behaviour diorder

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