Abstract:Genomic studies of human cancers have yielded a wealth of information about genes that are altered in tumors 1,2,3 . A challenge arising from these studies is that many genes are altered, and it can be difficult to distinguish genetic alterations that drove tumorigenesis from that those arose incidentally during transformation. To draw this distinction it is beneficial to have an assay that can quantitatively measure the effect of an altered gene on tumor initiation and other processes that enable tumors to pe… Show more
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