Screening for Elevated Blood Lead Levels in Children and Pregnant Women

Spanier, Adam J.; McLaine, Pat; Gilden, Robyn

doi:10.1001/jama.2019.2594

Cited by 5 publications

(3 citation statements)

References 13 publications

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“…Pollutants that may expose humans to lead include industrial waste, lead-acid batteries, metal smelting, lead-based paint, leaded gasoline and kerosene, lead-containing water pipes, and contaminated foods [ 32 , 38 – 42 ]. Children and pregnant women are more sensitive to lead toxicity than adults [ 38 , 43 ]. As the subjects in the present study were adults, the impact of lead exposure on sleep disorders may be higher than our estimate.…”

Section: Discussionmentioning

confidence: 99%

The Causal Association Between Blood Lead and Sleep Disorders: Evidence from National Health and Nutrition Examination Survey and Mendelian Randomization Analysis

Chen,

Zhang,

Zhang

et al. 2024

J Epidemiol Glob Health

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Background Poor sleep quality is a global public health concern. This study aimed to identify the risk factors for sleep disorders and clarify their causal effects. Methods Data were obtained from the National Health and Nutrition Examination Survey (NHANES) and Mendelian randomization (MR)-Base databases. Baseline characteristics of individuals with and without sleep disorders were compared. A multivariate logistic regression analysis was performed to calculate the effects of each variable on sleep disorders. Causal effects of blood lead levels and hypertension on sleep disorders were assessed using MR analysis. Results In total, 3660 individuals were enrolled in the study. The prevalence of self-reported sleep disorders was 26.21%. Serum lead level, serum mercury level, serum retinol level, prevalence of hypertension, and daily vigorous work duration were significantly higher for those in the sleep disorders group than the control group. After adjusting for various covariates, the effects of serum lead and hypertension on sleep disorders were stable from logistic regression models 1–4. MR analysis showed that blood lead levels were causally related to the risk of sleep disorders (odds ratio (OR) = 1.09, 95% confidence interval (CI) 1.01–1.17, P = 0.030). There was no causal link between elevated blood pressure and sleep disorders (OR = 0.99, 95% CI 0.94–1.04, P = 0.757). Goodness-of-fit tests and sensitivity analyses were used to verify the reliability of the results. Conclusions Blood lead is positively and causally associated with an increased risk of sleep disorders. These findings provide a novel perspective regarding sleep protection. Taking effective measures to reduce lead exposure may significantly improve sleep health.

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Section: Discussionmentioning

confidence: 99%

The Causal Association Between Blood Lead and Sleep Disorders: Evidence from National Health and Nutrition Examination Survey and Mendelian Randomization Analysis

Chen,

Zhang,

Zhang

et al. 2024

J Epidemiol Glob Health

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“…The U.S. Preventive Services Task Force recently highlighted key gaps in the evidence that is insufficient to either support or recommend against blood lead screening in pregnant women and children (Cantor et al 2019;Curry et al 2019;Jin 2019;Spanier et al 2019). The American College of Obstetricians and Gynecologists (ACOG), following the CDC's 2010 guidelines (CDC 2010), Table 3.…”

Section: Discussionmentioning

confidence: 99%

Blood Lead Levels in U.S. Women of Childbearing Age, 1976–2016

Ettinger

Egan

Homa

et al. 2020

Environ Health Perspect

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“…El mercurio y sus formas metiladas generan toxicidad desde muy bajas concentraciones, afectando en mayor medida al sistema nervioso central, sistema renal y hemático (19). La exposición al Pb en humanos afecta la salud, especialmente en niños pequeños y mujeres en estado de gestación (38). La exposición de fetos y niños al Pb está relacionada con trastornos neurológicos como el trastorno por déficit de atención e hiperactividad y déficits cognitivos (39).…”

Section: Materiales Y Métodosunclassified

Bioacumulación de mercurio y plomo en el pato Dendrocygna autumnalis en la subregión de la Mojana, Colombia

2022

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Objetivo. La Mojana es una zona biodiversa de humedales que se ubica en la región Caribe, siendo el hábitat de numerosas especies. La minería, aguas arriba, y las actividades agrícolas han generado la acumulación de metales pesados en estos ecosistemas. Se determinaron las concentraciones de mercurio (Hg) y plomo (Pb) en 47 muestras de sangre y plumas de Dendrocygna autumnalis (Pisingo) en dos sitios de La Mojana, Colombia. Materiales y métodos. Las concentraciones de Hg y Pb en sangre y plumas se cuantificaron mediante espectrofotometría de absorción atómica de vapor frío (CVAAS) y espectrometría de absorción atómica en horno de grafito (GFAAS), respectivamente. Resultados. Las más altas concentraciones de Hg y Pb en plumas y sangre fueron 475.4±180.5 ng/g, 873.59±412.06 ng/g y 9.87±10.6 ng/mL, 218.5±216.6 ng/mL, respectivamente. El 100% de las muestras de plumas de los individuos capturados sobrepasó el límite permisible de 40 ng/g para Hg en carne de pato establecido por la Unión Europea. Así mismo, el 47% de las muestras de sangre y el 53% de las de plumas de los individuos capturados excedieron los límites permisibles para plomo en carne de pato de 100 ng/g de la Unión Europea. Conclusiones. Las actividades mineras y agrícolas han generado procesos de acumulación de metales pesados en Dendrocygna autumnalis, lo cual representa una amenaza para la conservación de esta especie y un riesgo a la salud por consumo para los habitantes de la región.

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Screening for Elevated Blood Lead Levels in Children and Pregnant Women

Cited by 5 publications

References 13 publications

The Causal Association Between Blood Lead and Sleep Disorders: Evidence from National Health and Nutrition Examination Survey and Mendelian Randomization Analysis

The Causal Association Between Blood Lead and Sleep Disorders: Evidence from National Health and Nutrition Examination Survey and Mendelian Randomization Analysis

Blood Lead Levels in U.S. Women of Childbearing Age, 1976–2016

Bioacumulación de mercurio y plomo en el pato Dendrocygna autumnalis en la subregión de la Mojana, Colombia

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