Screening for Down syndrome based on maternal age or fetal nuchal translucency: a randomized controlled trial in 39 572 pregnancies

Saltvedt, Sissel; Almström, Harald; Kublickas, Marius; Valentin, Lil; Bottinga, Roger; Th, Bui; Cederholm, Maria; Conner, Peter; Dannberg, B; Malcus, Peter; Marsk, Anna; Grünewald, Charlotta

doi:10.1002/uog.1917

Cited by 41 publications

(48 citation statements)

References 18 publications

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“…However, as couples from neighboring countries received NT in very few cases, we decided to exclude non-Danish citizens. In Sweden, a significant effort has been made to document the usefulness of NT in screening for Down syndrome [Saltvedt et al 2005], and NT is offered routinely in Sweden as it is in Denmark. In Norway however, where the majority of the excluded couples came from, NT is not routinely available.…”

Section: Discussionmentioning

confidence: 99%

Prenatal diagnostics in TESA/PESA pregnancies in Denmark 1995-2007: a shift from invasive procedures to nuchal translucency examination

Fedder¹,

Erb

Humaıdan

et al. 2011

Systems Biology in Reproductive Medicine

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Evidently, children born after intracytoplasmic sperm injection (ICSI) are at an increased risk of having sex chromosomal abnormalities. Here we evaluate the change in methods used for prenatal diagnostics in patients having ICSI with epididymal or testicular sperm from the introduction of the procedure in 1995 until December 2007. Four hundred and fifty pregnancies resulted in the birth of 553 children. Of the Danish subpopulation 115 (34.2%) received nuchal translucency examination (NT) and 43 (12.8%) received invasive prenatal diagnostics (IPD). IPD was carried out in 11 out of 23 couples (48%) during the period 1995-1998. Since 2002, less than 10% chose to receive IPD. Twenty-one (57%) of 37 Danish women 37-44 years of age underwent IPD compared to only 22 (7.4%) of the 299 women less than 37 years of age (p < 0.001). Conversely, since 1999 the use of NT has gradually increased to a frequency of 88.9% in 2007. The partners of vasectomized men had significantly more often NT performed compared to those of non-vasectomized men. IPD were not otherwise associated with the etiology of azoospermia. This study documents a shift in prenatal diagnostics from IPD to NT for testicular sperm aspiration/percutaneous epididymal sperm aspiration (TESA/PESA) couples.

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Section: Discussionmentioning

confidence: 99%

Prenatal diagnostics in TESA/PESA pregnancies in Denmark 1995-2007: a shift from invasive procedures to nuchal translucency examination

Fedder¹,

Erb

Humaıdan

et al. 2011

Systems Biology in Reproductive Medicine

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“…They were provided with a standard set of instructions and asked to complete the templates for three papers of varying quality which were under review at the time: two randomised controlled trials (RCTs)8 9 and one non-randomised, controlled intervention study 10. They rated the relevance of the items on a scale from 1 (totally irrelevant) to 9 (essential item) and clarity of the instructions on a scale from 1 (instructions unclear) to 9 (instructions clear and unambiguous) and estimated the time taken to read the studies and complete the template.…”

Section: Methodsmentioning

confidence: 99%

Sharing hard labour: developing a standard template for data summaries in guideline development

Mlika-Cabanne

Harbour²,

H³

et al. 2011

BMJ Quality & Safety

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A literature review was conducted to identify existing evidence tables, and GIN member organisations were asked to provide the tables they use. The results were used to develop a minimum dataset (template) for studies addressing intervention questions. The template was pilot-tested by a group of guideline developers and reviewed at GIN conferences. RESULTS The literature search yielded 65 articles. These dealt with reporting standards and trial quality (eg, CONSORT statement) rather than which data should be extracted from studies. However, the checklist items given were considered useful. Nineteen GIN members provided evidence tables; 17 tables were used for analysis. The number of items included in the tables ranged from 8 to 19, with several items common to all tables. Within individual items, the level of detail varied widely. The draught template included a majority of items relating to objective data. Pilot testing revealed that the median time to read a paper and complete the template was 2 h for a randomised controlled trial and 2½ h for a non-randomised, controlled intervention study. The median rating for both relevance and clarity of items was high. CONCLUSION The template listing the items needed to summarise an interventional study is now available for large-scale testing by all organisations.

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“…The detection rate for women under the age of 35 with a triple screen ranges between 57% and 74%, with a constant 5% FPR (3,5). For women above the age of 35 (using similar cutoff values), the sensitivity increases to 87%, but the FPR also balloons to 25% (9).…”

Section: Second Trimester Screeningmentioning

confidence: 96%

Prenatal diagnosis and screening for aneuploidy

Lewis¹,

Jenkins²

2012

Obstetric Evidence Based Guidelines

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Screening for Down syndrome based on maternal age or fetal nuchal translucency: a randomized controlled trial in 39 572 pregnancies

Abstract: Objectives Nuchal translucency (NT) screening increases antenatal detection of Down syndrome (DS) compared to maternal age-based screening. We wanted to determine if a change in policy for prenatal diagnosis would result in fewer babies born with DS. Methods

Cited by 41 publications

References 18 publications

Prenatal diagnostics in TESA/PESA pregnancies in Denmark 1995-2007: a shift from invasive procedures to nuchal translucency examination

Prenatal diagnostics in TESA/PESA pregnancies in Denmark 1995-2007: a shift from invasive procedures to nuchal translucency examination

Sharing hard labour: developing a standard template for data summaries in guideline development

Prenatal diagnosis and screening for aneuploidy

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