Screening for depression and suicidality in psoriasis patients: A survey of US dermatologists

Liang, Sydney E.; Cohen, Jeffrey M.; Ho, Roger S.

doi:10.1016/j.jaad.2019.01.025

Cited by 9 publications

(8 citation statements)

References 4 publications

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“…A survey to US dermatologists in 2018 showed that a majority agreed on the requirement for regular depression and suicide ideation and behaviour screening in psoriasis patients. Only 27% reported asking their patients about mood or depression [44]. Furthermore, a UK study has shown low agreement between dermatologists and patients regarding psychological distress and that dermatologists often fail to take action when patients are identified as anxious or distressed [45].…”

Section: Discussionmentioning

confidence: 99%

Sex and Age Influence the Associated Risk of Depression in Patients with Psoriasis: A Retrospective Population Study Based on Diagnosis and Drug-Use

et al. 2020

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Background: The reported prevalence of depression among individuals with psoriasis varies substantially, and the effect of gender on depression distribution has revealed conflicting results. In addition, using medication to identify cases is uncommon. Objective: To study the prevalence of pharmacologically treated depression among individuals with and without psoriasis in a Swedish population using ICD-10 codes and data from the Swedish Prescribed Drug Register. Methods: A retrospective case-control population-based study was performed including all living individuals (age ≥18 years) in Region Jönköping, southern Sweden (n = 273,536). ICD-10 codes for the diagnosis of psoriasis (L40.*) and depression (F32.* and F33.*), and data on pharmacological treatment from the Swedish Prescribed Drug Register, were extracted from electronic medical records between April 9, 2008 and January 1, 2016. The extraction date was January 1, 2016. Results: The risk of pharmacologically treated depression was increased in individuals with psoriasis (age- and sex-adjusted OR 1.55; CI 1.43–1.68); 21.1% of women with psoriasis received pharmacological treatment for depression during the study period compared to 14.2% in the control population. Prevalence figures for depression were significantly higher in women with psoriasis compared to men. The risk of suffering from depression was highest among male and female patients with psoriasis under the age of 31 years. Conclusions: Depression is common among patients with psoriasis. The results of the current study underline the need for dermatologists to adopt a holistic approach, looking beyond the skin, when handling patients with psoriasis in every-day clinical practice.

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Section: Discussionmentioning

confidence: 99%

Sex and Age Influence the Associated Risk of Depression in Patients with Psoriasis: A Retrospective Population Study Based on Diagnosis and Drug-Use

et al. 2020

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“…As a result, psoriasis also affects the psychophysical health of patients by lowering their self-esteem and disrupting their social behavior. Depressive symptoms and sleep disturbances are also common in psoriatic patients [ 5 , 6 ].…”

Section: Introductionmentioning

confidence: 99%

Changes in Proteome of Fibroblasts Isolated from Psoriatic Skin Lesions

Gęgotek

Domingues

Wroński³

2020

IJMS

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The dermal fibroblasts are in constant contact with the cells of the immune system and skin epidermis. Therefore, they are essential for the development of lesions in psoriasis. The aim of this study was to assess the changes in the proteomic profile of fibroblasts in the dermis of psoriasis patients, and to discuss the most significant changes and their potential consequences. The proteomic results indicate that fibroblast dysfunction arises from the upregulation of proinflammatory factors and antioxidant proteins, as well as those involved in signal transduction and participating in proteolytic processes. Moreover, downregulated proteins in psoriatic fibroblasts are mainly responsible for the transcription/translation processes, glycolysis/ adenosine triphosphate synthesis and structural molecules. These changes can directly affect intercellular signaling and promote the hyperproliferation of epidermal cells. A better understanding of the metabolic effects of the proteomic changes observed could guide the development of new pharmacotherapies for psoriasis.

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“…Besides, psoriasis also involves a psychological burden, given the emotional and social impact on the patient's life 6 . Depression is currently a risk factor for cardiovascular diseases to be considered in patients with psoriasis 7 . Other psychosocial risk factors such as quality of life and self-perception of health may be decreased in patients with psoriasis 8 , 9 .…”

Section: Introductionmentioning

confidence: 99%

Psoriasis and associated risk factors: a cross-sectional analysis of the Brazilian Longitudinal Study of Adult Health

Cherubin

Tebar

Meneghini

et al. 2023

Rev. Assoc. Med. Bras.

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SUMMARY OBJECTIVE: This study investigated the association of psoriasis with cardiovascular risk factors and psychological aspects among participants of the Brazilian Longitudinal Study of Adult Health. METHODS: This is a cross-sectional study from the baseline data of the Brazilian Longitudinal Study of Adult Health cohort, collected between 2008 and 2010 in six state capitals of Brazil (i.e., Belo Horizonte, Porto Alegre, Rio de Janeiro, Salvador, São Paulo, and Vitória). Participants were active and retired civil servants from college and research institutions, aged between 35 and 74 years. Exclusion criteria included the intention to quit working at the institution, pregnancy, severe cognitive impairment, and, if retired, residence outside of a study center's corresponding area. Psoriasis case identification was based on a previous medical diagnosis of psoriasis. Cardiovascular risk profile, psychological aspects, and sociodemographic variables were investigated. RESULTS: Data from 15,105 participants were analyzed (mean age of 52.3 years, 51.3% women). The prevalence of psoriasis was 1.6% (n=236). Psoriasis was associated with higher education (OR 1.94 [CI 1.07–3.52]), health insurance plan (OR 1.56 [CI 1.08–2.25]), central obesity (OR 1.63 [CI 1.10–2.40]), smoking status (former OR 1.40 [CI 1.03–1.88]; current OR 1.61 [CI 1.08–2.40]), and very bad self-perception of health (OR 7.22 [CI 2.41–21.64]), remaining significant even after multivariate adjustment. Self-reported Black participants were less likely to have psoriasis (OR 0.45 [CI 0.26–0.75]). CONCLUSION: In a sample of healthy workers, psoriasis was associated with central obesity, smoking, and a very bad self-perception of health, which may contribute to future cardiovascular disease.

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Screening for depression and suicidality in psoriasis patients: A survey of US dermatologists

Cited by 9 publications

References 4 publications

Sex and Age Influence the Associated Risk of Depression in Patients with Psoriasis: A Retrospective Population Study Based on Diagnosis and Drug-Use

Sex and Age Influence the Associated Risk of Depression in Patients with Psoriasis: A Retrospective Population Study Based on Diagnosis and Drug-Use

Changes in Proteome of Fibroblasts Isolated from Psoriatic Skin Lesions

Psoriasis and associated risk factors: a cross-sectional analysis of the Brazilian Longitudinal Study of Adult Health

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