Screening for deletions of the Y chromosome involving the DAZ (Deleted in AZoospermia) gene in azoospermia and severe oligozoospermia

Simoni, Manuela; Gromoll, Jörg; Dworniczak, Bernd; Claus, R.; Abshagen, K.; Kamischke, Axel; Carani, Cesare; Meschede, Dieter; Behre, Hermann M.; Horst, Jürgen; Nieschlag, Eberhard

doi:10.1016/s0015-0282(97)80083-0

Cited by 180 publications

(19 citation statements)

References 22 publications

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“…A possible explanation for such variable phenotypes is the progressive germ cell regression over time, which has been reported in patients with AZFc deletions [3][4][5][6][7][8].…”

Section: Introductionmentioning

confidence: 99%

Increased apoptosis of germ cells in patients with AZFc deletions

Yamada

Fujita

Quan

et al. 2010

J Assist Reprod Genet

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“…A possible explanation for such variable phenotypes is the progressive germ cell regression over time, which has been reported in patients with AZFc deletions [3][4][5][6][7][8].…”

Section: Introductionmentioning

confidence: 99%

Increased apoptosis of germ cells in patients with AZFc deletions

Yamada

Fujita

Quan

et al. 2010

J Assist Reprod Genet

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“…It has been proposed that microdeletions of this region are probably responsible for testicular damage, leading to the development of undescended testis [19]. Moreover, patients with Y chromosome microdeletions and cryptorchidism have been reported in numerous studies [20][21][22][23][24]. However, there are studies reporting that there were no microdeletions in men with cryptorchidism [25].…”

Section: Introductionmentioning

confidence: 99%

Do microdeletions in the AZF region of the Y chromosome accompany cryptorchidism in Turkish children?

et al. 2007

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Studies on Y chromosome microdeletions are important due to a potential for the transmission of genetic abnormalities to offspring. Assisted reproduction techniques may cause the transmission of genetic abnormalities to offspring because the physiological fertilisation mechanism is bypassed. It was found that there was probably no aetiologic correlation between microdeletions in gene loci on the AZF-a, AZF-b and AZF-c regions of the Y chromosome and cryptorchidism.

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“…Current practice is to screen for AZFa, P5/P1 and AZFc deletions, and some advocate screening for gr/gr deletions as well [39,40]. The presence of an AZFa or P5/P1 deletion indicates an extremely low chance of finding sperm during a testicular sperm extraction (TESE) procedure [29 ].…”

Section: Class Of Sequence Genementioning

confidence: 99%