Screening for Coronary Artery Disease in Cancer Survivors

Velusamy, R.; Nolan, Mark; Murphy, Andrew; Thavendiranathan, Paaladinesh; Marwick, Thomas H.

doi:10.1016/j.jaccao.2022.12.007

Cited by 13 publications

(3 citation statements)

References 172 publications

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“…Given that certain treatments such as chemotherapy, radiotherapy, and immunotherapy can potentially increase coronary artery disease risk by triggering inflammation through endothelial damage, it would be necessary to integrate this information in future studies on cancer survivors. 53 Furthermore, it is important to note that the differences in the types of cancer and included in the NHIS may not accurately represent the cancer survivor population in the US, Europe, or elsewhere in the world. Therefore, larger multi-ethnic cohort studies are needed to confirm the generalizability of the findings.…”

Section: Study Limitationsmentioning

confidence: 99%

Association of metabolic health and obesity with coronary heart disease in adult cancer survivors

Kim,

Di Giovanna,

Jung

et al. 2024

Eur J Clin Investigation

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BackgroundThe metabolically healthy obese (MHO) phenotype is associated with an increased risk of coronary heart disease (CHD) in the general population. However, association of metabolic health and obesity phenotypes with CHD risk in adult cancer survivors remains unclear. We aimed to investigate the associations between different metabolic health and obesity phenotypes with incident CHD in adult cancer survivors.MethodsWe used National Health Insurance Service (NHIS) to identify a cohort of 173,951 adult cancer survivors aged more than 20 years free of cardiovascular complications. Metabolically healthy nonobese (MHN), MHO, metabolically unhealthy nonobese (MUN), metabolically unhealthy obese (MUO) phenotypes were created using as at least three out of five metabolic health criteria along with obesity (body mass index ≥ 25.0 kg/m2). We used Cox proportional hazards model to assess CHD risk in each metabolic health and obesity phenotypes.ResultsDuring 1,376,050 person‐years of follow‐up, adult cancer survivors with MHO phenotype had a significantly higher risk of CHD (hazard ratio [HR] = 1.52; 95% confidence intervals [CI]: 1.41 to 1.65) as compared to those without obesity and metabolic abnormalities. MUN (HR = 1.81; 95% CI: 1.59 to 2.06) and MUO (HR = 1.92; 95% CI: 1.72 to 2.15) phenotypes were also associated with an increased risk of CHD among adult cancer survivors.ConclusionsAdult cancer survivors with MHO phenotype had a higher risk of CHD than those who are MHN. Metabolic health status and obesity were jointly associated with CHD risk in adult cancer survivors.

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Section: Study Limitationsmentioning

confidence: 99%

Association of metabolic health and obesity with coronary heart disease in adult cancer survivors

Kim,

Di Giovanna,

Jung

et al. 2024

Eur J Clin Investigation

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“…According to data from the World Health Organization, cardiovascular disease (CVD) has become an urgent public health issue and it has been the major cause of morbidity and mortality. 1 As the prevalence increases globally, it is causing a great economic burden for society. Percutaneous coronary intervention (PCI), also known as coronary angioplasty and stent placement, is a widely used treatment for coronary atherosclerosis and thromboembolism, aiming to restore coronary blood flow.…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Mussel-Mimetic Hydrogel Coating with Anticoagulant and Antiinflammatory Properties on a Poly(lactic acid) Vascular Stent

Qiu,

Cheng,

Chen

et al. 2024

Biomacromolecules

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Biodegradable stents are the most promising alternatives for the treatment of cardiovascular disease nowadays, and the strategy of preparing functional coatings on the surface is highly anticipated for addressing adverse effects such as in-stent restenosis and stent thrombosis. Yet, inadequate mechanical stability and biomultifunctionality limit their clinical application. In this study, we developed a multicross-linking hydrogel on the polylactic acid substrates by dip coating that boasts impressive antithrombotic ability, antibacterial capability, mechanical stability, and self-healing ability. Gelatin methacryloyl, carboxymethyl chitosan, and oxidized sodium alginate construct a double-cross-linking hydrogel through the dynamic Schiff base chemical and in situ blue initiation reaction. Inspired by the adhesion mechanism employed by mussels, a triple-cross-linked hydrogel is formed with the addition of tannic acid to increase the adhesion and antibiofouling properties. The strength and hydrophilicity of hydrogel coating are regulated by changing the composition ratio and cross-linking degree. It has been demonstrated in tests in vitro that the hydrogel coating significantly reduces the adhesion of proteins, MC3T3-E1 cells, platelets, and bacteria by 85% and minimizes the formation of blood clots. The hydrogel coating also exhibits excellent antimicrobial in vitro and antiinflammatory properties in vivo, indicating its potential value in vascular intervention and other biomedical fields.

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Coronary microvascular dysfunction and cancer therapy-related cardiovascular toxicity

Chitturi,

Bhogal,

Kassaian

et al. 2024

Cardiovascular Revascularization Medicine

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Screening for Coronary Artery Disease in Cancer Survivors

Cited by 13 publications

References 172 publications

Association of metabolic health and obesity with coronary heart disease in adult cancer survivors

Association of metabolic health and obesity with coronary heart disease in adult cancer survivors

Mussel-Mimetic Hydrogel Coating with Anticoagulant and Antiinflammatory Properties on a Poly(lactic acid) Vascular Stent

Coronary microvascular dysfunction and cancer therapy-related cardiovascular toxicity

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