Screening for congenital hypothyroidism: Results of screening one million North American infants

Fisher, Delbert A.; Dussault, Jean H.; Foley, Thomas P.; Klein, Alan H.; LaFranchi, Stephen; Larsen, P. Reed; Mitchell, Marvin L.; Murphey, William H.; Walfish, Paul G.

doi:10.1016/s0022-3476(79)80133-x

Cited by 341 publications

(143 citation statements)

References 25 publications

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“…Outcomes of infants with congenital hypothyroidism had remarkably improved after the introduction of nationwide screening program [14,15]. In addition to positive effect on prognosis, newborn screening program had allowed identifying transient disorders of thyroid function in infancy [16].…”

Section: Discussionmentioning

confidence: 99%

Incidence and Risk Factor of Permanent Hypothyroidism in Preterm Infants

Chung¹

2017

J Neonatal Biol

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Background: To investigate the incidence and risk factors of permanent hypothyroidism in premature infants diagnosed with congenital hypothyroidism. Methods:A retrospective review of medical records of preterm infants was performed between March 2010 and December 2013. We included infants who were treated with thyroxine after being diagnosed with congenital hypothyroidism and persistent hyperthyrotropinemia. Exclusion criteria included an infants who were lost to follow up or earlier discontinuation of thyroxine medication and had proven permanent hypothyroidism. We performed trial offtherapy at 36 months of age.Results: A total of 49 infants were eligible for trial off-therapy at age 3 years. Permanent and transient hypothyroidism was diagnosed in 12 and 37 infants, respectively. Persistent hypothyroidism was more frequent in the infants with high TSH and low FT4 levels at initial screening and high incidence in abnormalities in thyroid imaging work-ups and positive anti-thyroid antibodies. Moreover, the average thyroxine dosage during follow-up was significantly higher in infants with persistent hypothyroidism (p<0.05). Conclusion:Thyroid dysfunction is common in preterm infants, and nearly 80% of infants showed transient hypothyroidism. Therefore, if there is no other risk factor for permanent hypothyroidism, it is possible to consider an earlier trail off-therapy for preterm infants.

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Section: Discussionmentioning

confidence: 99%

Incidence and Risk Factor of Permanent Hypothyroidism in Preterm Infants

Chung¹

2017

J Neonatal Biol

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“…A proporção de HC quanto ao sexo feminino e masculino de 2:1 também foi relatada por Dussault 3,14,15 .…”

Section: Discussionunclassified

Congenital hypothyroidism screening program: preliminary results

Nascimento¹,

Silva²,

Simoni³

et al. 1997

J Pediatr (Rio J)

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IntroduçãoO hipotireoidismo congênito (HC) consiste num distúr-bio metabólico sistêmico, caracterizado por uma secreção inadequada de hormônios tireoidianos, provocada por alterações funcionais e/ou anatômicas, e, mais raramente, por uma resistência periférica 1 . É uma causa de retardo mental grave e facilmente evitável, desde que seja diagnosticada e tratada precocemente [2][3][4][5][6] .A primeira descrição de uma criança com este distúrbio foi feita por Thomas Curling na Grã-Bretanha em 1850 7 .As dificuldades para o diagnóstico clínico precoce do HC se devem a ausência ou mesmo inespecificidade dos sinais e sintomas no período neonatal. O diagnóstico clíni-co precoce do HC é incomum. Os sinais e sintomas encontrados são: fontanela posterior aberta, icterícia prolongada, ResumoObjetivo: Os autores têm por objetivo relatar os primeiros resultados do programa de detecção precoce de hipotireoidismo congênito (HC), realizado no período de julho de 1993 a dezembro de 1994 no estado de Santa Catarina.Métodos: Foram estudados todos os lactentes triados para HC pelo Laboratório Central de Saúde do Estado de Santa Catarina (LACEN), no período de julho de 1993 a dezembro de 1994. Foi coletada uma amostra de sangue em papel filtro para dosagem de TSH por imunofluorometria, em triplicata. Na persistência de valores de TSH acima dos de corte, após a reconvocação, os pacientes foram encaminhados para avaliação especializada.Resultados: Dos 135.865 nascimentos ocorridos neste período, foram triadas 82.709 crianças com idade de 0 a 60 dias (61%). Das 82.709 amostras, 304 tiveram resultados anormais (TSH em sangue do cordão > 30µU/ml; de 2 a 7 dias > 20µU/ml; acima de 7 dias > 10µU/ml) e destes, 34 tiveram diagnóstico de HC. A média de idade na primeira consulta foi de 45 dias.Conclusões: A prevalência observada (1:2500) foi maior que a mundial, provavelmente devido a alguns casos de hipotireoidismo congênito transitório. Contudo, a distribuição por sexos (2:1) foi semelhante à descrita na literatura. As manifestações clínicas eram inespecíficas, o que reforça a necessidade do programa. Esforços estão sendo feitos para aperfeiçoar a estrutura do programa no intuito de iniciar a terapêutica o mais precocemente possível.J. pediatr. (Rio J.). 1997; 73(3):176-179: hipotireoidismo congênito, triagem neonatal, nível de corte. AbstractObjective: The authors report early results of a screening program for Congenital Hypothyroidism in Santa Catarina, Brazil.Methods: All the assays (82.709) analysed by Laboratório Central (LACEN) between July 1993 and December 1994 were studied. A blood sample was collected on filter paper for serum Thyroid Stimulating Hormone (TSH) measurement by fluoroimmunoassay, in triplicate. All children who had persistent abnormal TSH values (cord blood: TSH > 30 µU/ml; from 2 to 7 days: >20 µU/ml; older than 7 days: > 10 µU/ml) were recalled for clinical evaluation.Results: Out of 82.709 infants aged from 0 to 60 days (40% of the deliveries in this period), 304 presented abnormal results of TSH and 34 were co...

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“…[1][2][3] Neonatal hearing loss has a prevalence that is more than twice that of other newborn disorders amenable to screening such as congenital hypothyroidism and phenylketonuria. 4,5 Studies done in India using different hearing screening protocols have estimated the prevalence of neonatal hearing loss to vary between 1 and 8 per 1000 babies screened. Early identification and intervention for hearing loss by 6months of age provides better prognosis in language development, academic success, social integration and successful participation in the society.…”

Section: What This Paper Addsmentioning

confidence: 99%

Routine Newborn Hearing Screening – An Indian Experience

Kumar¹,

Kini²,

Sardangouda³

et al. 2016

IPCB

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Objective: Newborn Hearing Screening to detect the hearing problems in neonates has become a standard of care in the USA, Australasia and UK after recent guidelines. We undertook this as a routine procedure in our hospital since Jan 2007.Setting: Tertiary Maternity Hospitals in Bangalore, India.Participants: All babies born above 35 weeks at the hospital and were with the mothers during the first few days -and not requiring NICU admission.Results: Between Jan 2007 and Mar 2016 a total of 30,600 neonates were screened using Newborn Hearing Screening. 75 neonates who failed screening, a thorough clinical examination by the neonatologists revealed that 58 babies had a false positive result and passed the test after a week and 17 babies were investigated with an audiogram by a Paediatric Audiologist and 8 out of those fifteen infants had hearing difficulties requiring treatment by an ENT Surgeon. Conclusion:These data confirm that Newborn Hearing screening of apparently well newborns should become a standard of care in India like many other developed countries and is very cost effective.

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Screening for congenital hypothyroidism: Results of screening one million North American infants

Cited by 341 publications

References 25 publications

Incidence and Risk Factor of Permanent Hypothyroidism in Preterm Infants

Incidence and Risk Factor of Permanent Hypothyroidism in Preterm Infants

Congenital hypothyroidism screening program: preliminary results

Routine Newborn Hearing Screening – An Indian Experience

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