Screening for colorectal cancer using a quantitative immunochemical faecal occult blood test: a feasibility study in an Asian population

Fu, Wang; Kam, Ming Hian; Ling, Weiming; Ong, S.-F.; Suzannah, N.; Eu, Kong‐Weng

doi:10.1007/s10151-009-0515-1

Cited by 9 publications

(15 citation statements)

References 18 publications

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“…(2)(3)(4)(5)(6) The reported specificity and sensitivity of FIT for colorectal cancer is 93.4%-96.9% and 61.5%-87.5%, respectively. (9)(10)(11)(12)(13) While two previous studies have also evaluated the use of FOBT in Singapore, their sample sizes were smaller than that in our study. (11,14) We found the compliance rate to be relatively low in our series.…”

Section: Discussionmentioning

confidence: 59%

Opportunistic screening for colorectal neoplasia in Singapore using faecal immunochemical occult blood test

Tan

Tang

Koo³

2013

SMedJ

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Section: Discussionmentioning

confidence: 59%

Opportunistic screening for colorectal neoplasia in Singapore using faecal immunochemical occult blood test

Tan

Tang

Koo³

2013

SMedJ

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“…Installation of sophisticated hardware is not required. Given a positivity rate of 5.5% to 11.0%, 12,13,17,19,28,29 however, it would have a significant impact on health care services. A major increase in the number of referrals for colonoscopy would be anticipated and thus require a corresponding increase in the availability of endoscopy centres and endoscopists.…”

Section: Discussionmentioning

confidence: 99%

“…18,28,30,31 The PPV ranges from 5.2% to 12.8% at a cut-off value of 75 ng/mL. 12,13,[17][18][19][28][29][30][31][32] The NNScreen and NNScope ranges from 213 to 936 and 12,13,17,19,[28][29][30]32 These results are summarised in Table 2. For advanced adenoma, the sensitivity and specificity ranges from 33.9% to 41.3% and 91.4% to 97.3%, respectively.…”

Section: Immunochemical Faecal Occult Blood Testingmentioning

confidence: 93%

“…It requires no dietary restrictions 16 and has a participation rate of 38.9% to 71.9%. [17][18][19] The results can be qualitative or quantitative. 20 Sampling technique, distribution of blood in faeces, and sample instability make true quantification difficult, however.…”

Section: Immunochemical Faecal Occult Blood Testingmentioning

confidence: 99%

“…27 The positivity rate of iFOBT ranges from 5.5% to 11.0%. 12,13,17,19,28,29 The sensitivity and specificity for CRC ranges from 53.3% to 94.1% and 87.5% to 96.9%, respectively. 18,28,30,31 The PPV ranges from 5.2% to 12.8% at a cut-off value of 75 ng/mL.…”

Section: Immunochemical Faecal Occult Blood Testingmentioning

confidence: 99%

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Alternatives to colonoscopy for population-wide colorectal cancer screening

Leung¹,

Foo²,

Chan³

et al. 2016

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International collaboration between Japan and Chile to improve detection rates in colorectal cancer screening

Okada

Kawachi²,

Ito

et al. 2015

Cancer

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of 10,575 asymptomatic participants were enrolled in PRENEC. Participants with positive immunochemical fecal occult blood test (iFOBT) results or a family history of CRC underwent colonoscopy. The colonoscopy results from a similar, previous project in Chile (PREVICOLON) were compared with those from PRENEC. Furthermore, the initial colonoscopies of 1562 participants in PRENEC were analyzed according to whether the colonoscopists were from TMDU or Chile. RESULTS: The complete colonoscopy, adenoma detection, and cancer detection rates were 88.0%, 26.7%, and 1.1%, respectively, in PREVICOLON, while the corresponding values were 94.4%, 41.8%, and 6.0%, respectively, in PRENEC. In PRENEC, 107 cases of CRC were detected, amounting for 1.0% of all participants. Considering initial colonoscopies in PRENEC, the complete colonoscopy, adenoma detection, and cancer detection rates were 97.4%, 45.3%, and 9.3%, respectively, for physicians at TMDU and 93.3%, 41.5%, and 5.1%, respectively for Chilean physicians. The detection rates of intramucosal cancer were 7.3% and 3.7%, respectively, for TMDU and Chilean physicians. CONCLUSIONS: Quality indicators of colonoscopy substantially improved from PREVICOLON to PRENEC. The assessments made by Chilean physicians alone were improved in PRENEC, but remained better in the TMDU group. Moreover, physicians from TMDU detected more CRCs than Chilean physicians, especially at earlier stages. Cancer 2016;122:71-7. V C 2015 American Cancer Society.KEYWORDS: adenoma detection rate, colorectal cancer, colonoscopy, diagnostic techniques and procedures, international cooperation, screening, training programs. INTRODUCTIONColorectal cancer (CRC) is the third most common cancer and the fourth most common cause of mortality in the world, accounting for approximately 694,000 deaths in 2012. 1 Although CRCs have generally been more common in the countries of North America, Oceania, and Europe, the incidence of CRC in Asian and South American countries has increased considerably during the past decade. In Chile, mortality from CRC has increased rapidly over the past 15 years, 2 and the prevention of CRC has come to be recognized as an urgent issue that might be addressed through organized screening systems.Some studies have reported that screening with a fecal occult blood test (FOBT) has reduced CRC mortality and have suggested FOBT as a suitable population-based screening test for CRC. [3][4][5] Screening for CRC with FOBT not only leads to the detection of advanced CRCs, but also results in detection at earlier clinical stages. 6 Another advantage of screening with FOBT is that the removal of adenomatous, precancerous polyps can decrease the incidence of CRC 7,8 and consequently reduce mortality from CRC. 9 In particular, immunochemical FOBT (iFOBT) has been shown to be more sensitive than guaiac-based FOBT. 10 Reduced mortality and the detection of CRC in earlier stages results in high costeffectiveness and lowered health costs for both patients and the government. 11 In Chile, a prospective mult...

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Screening for colorectal cancer using a quantitative immunochemical faecal occult blood test: a feasibility study in an Asian population

Abstract: The qFOBT at a positive faecal haemoglobin threshold of 100 ng/ml has a high positive predictive value and is an effective screening tool for colorectal cancer in an Asian population.

Cited by 9 publications

References 18 publications

Opportunistic screening for colorectal neoplasia in Singapore using faecal immunochemical occult blood test

Opportunistic screening for colorectal neoplasia in Singapore using faecal immunochemical occult blood test

Alternatives to colonoscopy for population-wide colorectal cancer screening

International collaboration between Japan and Chile to improve detection rates in colorectal cancer screening

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