Screening for cognitive and behavioral change in amyotrophic lateral sclerosis/motor neuron disease: a systematic review of validated screening methods

Simon, Natalie

doi:10.1080/21678421.2018.1530264

Cited by 33 publications

(31 citation statements)

References 35 publications

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“…In this way, the instruments could be accurately compared in terms of validity and applicability. Regarding the cognitive screening instruments, the FAB, ALS-CBS, and ECAS show a promising validity (9). Furthermore, no practice effects of the ECAS were found for ALS patients after 6 months and up to 18 months (88).…”

Section: Discussionmentioning

confidence: 93%

“…However, caution should be taken as the MiND-B may miss specific behavioral impairments that are part of the Rascovsky criteria (9). In contrast, the ALS-FTD-Q, BBI and ALS-CBS assess a broad spectrum of behavioral changes, and might, therefore, be more suitable for screening for behavioral changes in ALS-(FTD) patients (9).…”

Section: Resultsmentioning

confidence: 99%

“…Recently, a systematic review on the validity of six different ALS-specific neuropsychological screeners was published (9). In this present review, we included all screeners frequently used in clinical care or scientific studies (regardless of whether they were designed specifically for use in ALS) and provided an overview/comparison of the practical aspects of these instruments; which screeners are most commonly used, which cognitive and behavioral domains are assessed, whether can they be adapted to physical disability, availability in multiple languages, availability of alternate versions for longitudinal use, time required to administer each test, etc.…”

Section: Introductionmentioning

confidence: 99%

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An overview of screening instruments for cognition and behavior in patients with ALS: selecting the appropriate tool for clinical practice

Gosselt

Nijboer

2020

Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration

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Objective: Patients with amyotrophic lateral sclerosis (ALS) not only show motor deficits, but may also have cognitive and/ or behavioral impairments. Recognizing these impairments is crucial as they are associated with lower quality of life, shorter survival, and increased caregiver burden. Therefore, ALS-specific neuropsychological screening instruments have been developed that can account for motor and speech difficulties. This study provides an overview and comparison of these screeners. Methods: A systematic review was conducted using Medline and Embase. Articles describing cognitive/behavioral screening instruments assessed in ALS patients were included. Screening instruments were compared on multiple factors, such as domains, adaptability, required time, and validation. Results: We included 99 articles, reporting on nine cognitive screeners (i.e. ACE-R, ALS-BCA, ALS-CBS, ECAS, FAB, MMSE, MoCA, PSSFTS, and UCSF-SB), of which five ALS-specific. Furthermore, eight behavioral screeners (i.e. ALS-FTD-Q, AES, BBI, DAS, FBI, FrSBe, MiND-B, and NPI) were reported on, of which three ALS-specific. Conclusion: Considering the broad range of cognitive domains, adaptability, and satisfying validity, the ALS-CBS and ECAS appear to be the most suitable screeners to detect cognitive and behavioral changes in ALS. The BBI appears to be the best option to screen for behavioral changes in ALS, since all relevant domains are assessed, motor-related problems are considered, and has a satisfactory validity. The MiND-B and ALS-FTD-Q are promising as well. In general, all screening instruments would benefit from additional validation research to gain greater insights into test characteristics and to aid clinicians in selecting screening tools for use in clinical practice.

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Section: Discussionmentioning

confidence: 93%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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An overview of screening instruments for cognition and behavior in patients with ALS: selecting the appropriate tool for clinical practice

Gosselt

Nijboer

2020

Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration

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“…We assessed neuropsychological characteristics of ALS patients and HC participants by means of the ECAS [117]. The ECAS allows for the assessment of both ALS-specific and ALS-nonspecific neuropsychological characteristics with strong clinical validity [130]. However, we did not find evidence for any differences between ALS patients and HC participants with regard to the ECAS (see Table A1).…”

Section: Study Limitations and Directions For Future Researchmentioning

confidence: 89%

A Computational Study of Executive Dysfunction in Amyotrophic Lateral Sclerosis

Steinke

Lange

Seer

et al. 2020

JCM

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Executive dysfunction is a well-documented, yet nonspecific corollary of various neurological diseases and psychiatric disorders. Here, we applied computational modeling of latent cognition for executive control in amyotrophic lateral sclerosis (ALS) patients. We utilized a parallel reinforcement learning model of trial-by-trial Wisconsin Card Sorting Test (WCST) behavior. Eighteen ALS patients and 21 matched healthy control participants were assessed on a computerized variant of the WCST (cWCST). ALS patients showed latent cognitive symptoms, which can be characterized as bradyphrenia and haphazard responding. A comparison with results from a recent computational Parkinson’s disease (PD) study (Steinke et al., 2020, J Clin Med) suggests that bradyphrenia represents a disease-nonspecific latent cognitive symptom of ALS and PD patients alike. Haphazard responding seems to be a disease-specific latent cognitive symptom of ALS, whereas impaired stimulus-response learning seems to be a disease-specific latent cognitive symptom of PD. These data were obtained from the careful modeling of trial-by-trial behavior on the cWCST, and they suggest that computational cognitive neuropsychology provides nosologically specific indicators of latent facets of executive dysfunction in ALS (and PD) patients, which remain undiscoverable for traditional behavioral cognitive neuropsychology. We discuss implications for neuropsychological assessment, and we discuss opportunities for confirmatory computational brain imaging studies.

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“…Feasibility studies, however, showed that the ECAS might be more suitable, and hence preferable, for screening cognitive function in ALS patients compared to the FAB and MoCA, a finding that is in line with that of another systematic review. 71 While several screening tests have been developed to detect cognitive changes, the Mental Deterioration Battery + Notes: +++ or -= Strong evidence with consistent positive or negative results from multiple studies with good methodological quality or one study with excellent methodological quality. ++ or -= Moderate evidence with consistent positive or negative results from multiple studies with fair methodological quality or one study with good quality.…”

Section: Discussionmentioning

confidence: 99%

<p>Psychometric Properties of Cognitive Assessment in Amyotrophic Lateral Sclerosis: A Systematic Review</p>

Taule¹,

Søvik

Lein³

et al. 2020

PROM

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Purpose: We aimed to list all tests used to assess cognitive change in patients with amyotrophic lateral sclerosis (ALS) and to provide a descriptive synthesis of the psychometric properties of tests that were evaluated in a population of ALS patients. Materials and Methods: The protocol is registered in PROSPERO (ID: CRD42017055603). We systematically search for literature in 11 databases. Full-text articles, in any language, with original research were included. All included articles were scrutinised by two independent authors. Disagreement was resolved by consensus. The framework of Lezak informed conceptualises of the tests identified. To evaluate methodological quality, we used the Consensus-based Standards for the Selection of Health Measurement Instruments (COSMIN). Data were synthesised using criteria proposed by the Cochrane Back Review Group. Results: Of 319 included articles, 46 articles reported information on the psychometric properties of cognitive tests used in patients with ALS. We found that the highest level of evidence was supported for the Reading the Mind in the Eye Test (RME), Addenbrooke's Cognitive Evaluation (ACE) and Frontal Assessment Battery (FAB). Moderate level of evidence was found for the screening tests; Edinburgh Cognitive and Behavioural ALS Screen (ECAS) and the Montreal Cognitive Assessment (MoCA). Conclusion: The screening test, ECAS and the social cognition test, RME, may have some advantages over other tests that have been used for assessing cognitive change in ALS patients. Recommendations of ALS-specific tests with sound psychometric properties are urgently needed.

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Screening for cognitive and behavioral change in amyotrophic lateral sclerosis/motor neuron disease: a systematic review of validated screening methods

Cited by 33 publications

References 35 publications

An overview of screening instruments for cognition and behavior in patients with ALS: selecting the appropriate tool for clinical practice

An overview of screening instruments for cognition and behavior in patients with ALS: selecting the appropriate tool for clinical practice

A Computational Study of Executive Dysfunction in Amyotrophic Lateral Sclerosis

<p>Psychometric Properties of Cognitive Assessment in Amyotrophic Lateral Sclerosis: A Systematic Review</p>

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