Screening for coeliac disease in preschool Greek children: the feasibility study of a community‐based project

Abstract

This protocol using rapid immunochromatographic test for the detection of both IgA deficiency and CD is easy to be performed by nonmedical staff in a community setting, enabling the accurate identification of new CD cases among asymptomatic population.

Patients with eating disorders showed no signs of coeliac disease before and after nutritional intervention

“…Karagiozoglou‐Lampoudi et al. reported a prevalence of one of 154 preschool Greek children, while another study conducted in the adult Greek population estimated a prevalence of about one of every 558 . The size of our study group was almost within detection limits according to the prevalence in the paediatric population .…”

Global Prevalence of Celiac Disease: Systematic Review and Meta-analysis

“…The pooled prevalence of biopsy-proven CD ranged from 0.5% (95% CI, 0.2%-0.9%) in Africa 11,31,33,34 to 0.8% (95% CI, 0.6%-1.1%) in Europe. [53][54][55][56][57][58][59][60][61]63,65,66,68,70,71,74,76,77,80,[82][83][84][85][87][88][89][90][91][92][93]115,116 Of 7 studies included in the calculation of seroprevalence from North America, 6,95-100 biopsies were not performed in 4 studies. 95,97,99,100 In 2 other studies only 22.6% and 26.9% seropositive individuals underwent a biopsy and thus could not be included in this part of the analysis.…”

“…Of 57 studies included in the calculation of the pooled prevalence of biopsy-confirmed CD, 43 studies reported a separate pooled prevalence for pediatric and adult CD patients. 10,11,31,33,34,[36][37][38][39][40][41][42]47,48,50,53,56,57,59,61,65,66,68,70,76,77,80,82,83,85,[88][89][90][91][92][93]101,102,105,109,111,116,117 A total of 276 of 40,076 screened adults had CD, providing a pooled prevalence of 0.5% (95% CI, 0.3-0.8). Of 65,957 screened children, 891 children had CD, with a pooled prevalence of 0.9% (95% CI, 0.6-1.3), which was higher than that in adults (P < .001).…”

“…The pooled global prevalence of CD between January 2011 and March 2016 was 0.8% (95% CI, 0.5%-1%), suggesting an increase in the prevalence of CD over time. 9,11,31,33,37,[39][40][41][42]47,48,74,77,80,82,84,85,87,[89][90][91][92][93]97,105,109,111 The heterogeneity for this group was 94%.…”

Diagnostic Yield of 2 Strategies for Adult Celiac Disease Identification in Primary Care

“…[24][25][26][27] This rapid whole blood self-TG2-based IgA-class fingertip test uses the patient's own endogenous TG2 found in the erythrocytes of a whole blood sample. When the fingertip blood is hemolyzed, the liberated TG2 forms a complex with circulating autoantibodies, if present in the same sample.…”