Screening for cervical cancer in the developing world

Cronjé, H. S.

doi:10.1016/j.bpobgyn.2005.02.005

Cited by 53 publications

(37 citation statements)

References 49 publications

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“…Other provinces in the country have also failed to meet this target. [21][22][23] Although there were notable increases in screening coverage rates across all the provinces between 2007 and 2010, none of the provinces achieved the target of 70%. 24 Several issues have been cited to explain the low coverage rates, including lack of awareness among the target population; inadequate trained personnel to perform the screening tests, read smears and interpret the results; poor communication between the screening sites and laboratories; and inaccessibility of the facilities to diagnose and treat patients who have been detected through the screening process.…”

Section: Discussionmentioning

confidence: 99%

Cervical cancer screening programme in Limpopo province: January 2007 to December 2010

Mamahlodi

Kuonza

Candy

2013

Southern African Journal of Gynaecological Oncology

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(72.7%) were within the recommended screening age (30 years and older). Annual screening coverage rates ranged from 2.9-4.2% of the population of women aged 30 years and older. The cumulative screening coverage during the four years was 13.7%. The mean smear adequacy rate during this time was 98.5%. Of the 202 251 smears, 5 237 (2.5%) reflected high-grade squamous intraepithelial lesions, while 238 (0.2%) contained malignant lesions. Conclusion:The cervical cancer screening programme in Limpopo improved during the study period, but still fell short of national goals. Key areas that require strengthening include low screening coverage and the screening of young women who are at less risk of acquiring cervical cancer.

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Section: Discussionmentioning

confidence: 99%

Cervical cancer screening programme in Limpopo province: January 2007 to December 2010

Mamahlodi

Kuonza

Candy

2013

Southern African Journal of Gynaecological Oncology

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“…In Colombia, the latest reported rate for 2003-2004 was 36.8 per 100,000 women (6) and the adjusted rate of mortality from this cause in 2002 was 18.2 per 100,000 women (7). Therefore, cervical cancer should be considered as a public health problem which requires highly effective screening techniques to detect pre-invasive lesions, and to decrease morbidity and mortality caused by this disease (1,(8)(9)(10)(11).…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Electrical Impedance Spectroscopy for Cervical Intraepithelial Lesions Detection

Echeverri¹,

Botero²,

Sánchez³

2015

biosa

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Objective: To evaluate the diagnostic accuracy of electrical impedance spectroscopy (EIS) in detection of pre-invasive cervical lesions. Design: Cross-sectional study of diagnostic validity carried out with 265 women between 15 and 55 years with abnormal pap smear report, referred to colposcopy, who were evaluated between January 2008 and June 2010 in the Cervical Pathology and Colposcopy Network in the Departments of Caldas and Risaralda (Colombia). Measurements of electrical impedance spectroscopy of the cervix were made, new pap smear samples were taken, colposcopic examination and colposcopically directed biopsies were performed. Results: The evaluated parameters were resistivity of the extracellular space (R), resistivity of the intracellular space (S), cell membrane capacitance (Cm) and characteristic frequency (Fc). The results obtained for R parameter were: in squamous normal tissue 21.27 +/-16.48 (Ω-m); in high-grade lesions 4.28 +/-2.28 (Ω-m); and in low-grade lesions 10.1 +/-4.59 (Ω-m), showing a decrease of R in neoplastic tissue compared to normal tissue. The sensitivity of the EIS was 0.88 for high grade lesions and 0.71 for low grade lesions. The area under the ROC curves for high grade lesions /normal epithelium was 0.96, for low grade lesions/ normal epithelium was 0.76 and for high EVALUATION OF ELECTRICAL IMPEDANCE SPECTROSCOPY FOR CERVICAL INTRAEPITHELIAL LESIONS DETECTION P a l a b r a s c l a v e :e l e c t r i c a l i m p e d a n c e , intraepithelial lesion, cervical cancer. EVALUACIÓN DE 27Evaluation of electrical impedance spectroscopy for cervical intraepithelial lesions detection colposcopia en los departamentos de Caldas y Risaralda (Colombia). Se realizaron lecturas de espectroscopia de impedancia eléctrica del cuello uterino, nueva toma de citología, colposcopia y biopsias dirigidas. Resultados: Los parámetros evaluados fueron la resistividad del espacio extracelular (R), la resistividad del espacio intracelular (S), la capacitancia de la membrana celular (Cm) y la frecuencia característica (Fc). Los resultados obtenidos para la variable R fueron: en tejidos escamosos normales de 21,27+/-16,48 (Ω-m), en lesiones de alto grado 4,28+/-2,28 (Ω-m) y en lesiones de bajo grado 10,1+/-4,59 (Ω-m), evidenciando una disminución de R en los tejidos lesionados respecto a los normales. La sensibilidad de la EIE fue de 0,88 para lesiones de alto grado y de 0,71 para lesiones de bajo grado. El área bajo las curvas COR para lesiones de alto grado/ epitelio normal fue de 0,96; lesiones de bajo grado/epitelio normal 0,76 y lesión alto grado/ bajo grado 0,90. Conclusiones: Este estudio permitió establecer que la EIE es una técnica útil para la detección y caracterización de lesiones intraepiteliales del cuello uterino, con una precisión diagnóstica mayor al 75%, con sensibilidad y especificidad superiores al 69%, un valor predictivo positivo aceptable y un valor predictivo negativo, cercano al 90%.

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“…In recent years, although the widespread screening of cervical cancer, especially the systemic use of the Papanicolaou (Pap) smear (Cronje, 2005), cervical cancer remains the second most common cause of death from cancer in women worldwide (Sreejata et al, 2012), China accounts for 29% of the 51,000,000 new cases of cervical cancer each year (Kim et al, 2009). But due to cervical cancer screening, cervical cancer can be detected early and is younger trend, expecially early cervical cancer and cervical intraepithelial neoplasia (CIN), some young patients with no children had a strong desire for fertility.…”

Section: Introductionmentioning

confidence: 99%

Efficacy of Multiple Low-dose Photodynamic TMPYP4 Therapy on Cervical Cancer Tumour Growth in Nude Mice

Liu¹,

Sun²,

Wei³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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Objective: Photodynamic therapy (PDT) is an emerging therapeutic procedure suitable for the treatment of cervical cancer. However, the side effects of PDT are severe, including skin ulceration, so we designed an experiment to examine the effects of multiple low-dose photodynamic therapy of 5, 10, 15, 20-tetrakis(1-methylpyridinium-4-yl) porphyrin (Tmpyp4) on tumour growth by utilizing a model in nude mice implanted with Hela cervical cancer cells. Materials and Methods: Female BALB/c nude mice (aged 5-6 weeks, weighing 18-20 g) were used. Hela cervical cancer cells were injected subcutaneously (1×10 7 cells/200 μL). Ten days after injection, the mice were divided into three groups (n=6), the A group of controls without any treatment, the B group receiving a single-treatment with Tmpyp4 (10 mg/kg, intratumor injection) and irradiation (blue laser, 108 J/cm 2 ), and the C group given three-treatments with Tmpyp4 (10 mg/ kg, intratumor injection) and irradiation at intervals of two days. After starting treatment, tumours were measured every two days, to assess growth. At 2 weeks after the last treatment of C group, tumour tissue and organs were collected from each mouse to evaluate tumor histology and organ damage. Results: Tumour growth in C group was significantly inhibited compared with A and B groups (P <0.05), without any injury to the skin and internal organs. Conclusion: Our novel findings demonstrated that multiple low-dose photodynamic therapy of Tmpyp4 could inhibit cervical cancer growth significantly with no apparent side effects.

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Screening for cervical cancer in the developing world

Cited by 53 publications

References 49 publications

Cervical cancer screening programme in Limpopo province: January 2007 to December 2010

Cervical cancer screening programme in Limpopo province: January 2007 to December 2010

Evaluation of Electrical Impedance Spectroscopy for Cervical Intraepithelial Lesions Detection

Efficacy of Multiple Low-dose Photodynamic TMPYP4 Therapy on Cervical Cancer Tumour Growth in Nude Mice

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