Screening for Cancers of the Lung and Colon

Richert-Boe, Kathryn; Humphrey, Linda L.

doi:10.1001/archinte.1992.00400240022003

Cited by 12 publications

(1 citation statement)

References 48 publications

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“…The generally accepted error rate for detection of early lung cancer by chest radiograph is 20 to 50%. 21 Realizing that screening chest radiographs 22,23 have proven ineffectual, even in high-risk patients, the asymptomatic patient usually come to medical attention as an unexpected result of a radiological examination.…”

Section: Presentationmentioning

confidence: 99%

Lung Cancer

Iannettoni¹,

Lynch²

1999

Semin Respir Crit Care Med

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Section: Presentationmentioning

confidence: 99%

Lung Cancer

Iannettoni¹,

Lynch²

1999

Semin Respir Crit Care Med

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Lung cancer surgery. A critical review of the evidence

Lederle

Niewoehner

1994

Archives of Internal Medicine

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Surgery is generally considered to be the treatment of choice for anatomically localized non-small-cell lung cancer, but its effectiveness remains unproven. Observational studies have been of limited value because the criteria by which patients are selected for surgery create substantial differences between patients who undergo surgery and those who do not. One small randomized trial of surgery vs radiotherapy was inconclusive, but several large trials of lung cancer screening have provided indirect evidence against a benefit from surgery. Two ongoing randomized trials, one on extensive vs limited resection and the other on the effect of surgery in more extensive disease, may provide further insight into the effectiveness of surgery in the treatment of localized non-small-cell lung cancer. Development of a large randomized trial to directly assess the effectiveness of surgery in the treatment of localized non-small-cell lung cancer has been precluded by ethical concerns, but may need to be reconsidered if indicated by the findings of the two ongoing studies.

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Dysutility of Screening Chest Roentgenograms for Lung Cancer: The Ulysses Syndrome

Reich¹

1993

Arch Intern Med

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on a good broad overview of the history and current status of oral anticoagulant drugs. 1 In this regard, I would like to mention briefly some recent data that may be of interest to readers. Kant and colleagues2 have described the occurrence of warfarin-induced skin necrosis in relationship to peritoneal dialysis\p=m-\associated loss of protein S. It is suggested that these losses may become critical in certain settings and, hence, this complication must be kept in mind when managing the patients with peritoneal dialysis who receive warfarin therapy.Ansell discusses the prompt administration of vitamin K and the use of prostacyclin in the management of this condition. Some investigators3 have demonstrated the continuation or reinstitution of oral anticoagulant therapy in these patients without further skin involvement. It is postulated that, as skin necrosis occurs due to a more rapid reduction in protein C levels compared with other factors affected by oral anticoagulants, this temporary imbalance resolves as other coagulation factor levels also be¬ come depressed. This would explain why further skin ne¬ crosis has been shown not to occur in spite of continuing the medication. This interesting concept certainly war¬ rants further investigation.While oral anticoagulants are not recommended in any trimester of pregnancy, the role of these drugs in the nursing mother has been studied by two groups. In one study,4 warfarin was not detected either in the breast milk of 13 nursing mothers or in the plasma of any of seven infants tested. In the other,3 two breast-fed infants of nurs¬ ing mothers receiving oral anticoagulants were found to have 100% of control activity for prothrombin time and factors V, VII, and X. These studies suggest that oral an¬ ticoagulants may be used safely in the nursing mother as they are not present in breast milk and such use does not induce an anticoagulant effect in the breast-fed infant.

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Screening for Cancers of the Lung and Colon

Cited by 12 publications

References 48 publications

Lung Cancer

Lung Cancer

Lung cancer surgery. A critical review of the evidence

Dysutility of Screening Chest Roentgenograms for Lung Cancer: The Ulysses Syndrome

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