Screening for Booroola (FecB) and Galway (FecXG) mutations in Indian sheep

Kumar, Satish; Mishra, Anil Kumar; Kolte, Atul P.; Dash, SK; Karim, S. A.

doi:10.1016/j.smallrumres.2008.09.007

Cited by 38 publications

(27 citation statements)

References 25 publications

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“…In contrast, FecB mutations are reported in several sheep breeds, such as Booroola Merino [7] , Belclare, Cambridge, China Small Tailed Han, Hu [5] , Garole, Javanese [13] , Kendrapada [12] and Romney sheep [17] .…”

Section: Discussionmentioning

confidence: 94%

“…The FecX G mutation was analyzed in Garole, Kendrapada [12] , Malpura, Deccani, Baluchi [32] and Sangsari sheep [14] ; however, none of these sheep breeds carried the FecX G mutation in the BMP15 gene. Additionally, the FecX G mutation was identified in Small Tailed Han, Belclare and Cambridge sheep [1,33] .…”

Section: Discussionmentioning

confidence: 99%

“…These extra ovulations subsequently increased litter size by approximately 1.0 and 1.5, respectively [4,10] . FecB gene mutations have been reported in many other sheep breeds, such as Booroola Merino [7] , Belclare, Cambridge, China Small Tailed Han, Hu [5] , Romney [11] , Kendrapada [12] , Garole and Javanese sheep [13] . In contrast, FecB mutations were not detected in Thoka, Woodlands, Olkuska, Lacaune [13] and Sangsari sheep [14] .…”

Section: Introductionmentioning

confidence: 99%

“…In general, heterozygous ewes with mutations in both FecB and FecX G exhibited increased fertility compared with ewes harboring a mutation in only one of these genes [6] . The Galway mutation has been identified in Cambridge [16] , Garole, Kendrapada [12] and Small Tailed Han sheep [19] . Hanrahan et al [16] estimated the effect of FecX G to be 0.77 and 1.18 in Belclare and Cambridge ewes, respectively.…”

Section: Introductionmentioning

confidence: 99%

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Sakız Irkı Koyunlarda FecB, BMP15 ve CAST Genlerindeki Mutasyonların Analizi

Dinçel¹,

Ardıçlı²,

Soyudal³

et al. 2015

Kafkas Univ Vet Fak Derg

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Fertility traits, such as the ovulation rate and the number of offspring at birth, are genetically regulated by fecundity genes. This study was performed to identify DNA polymorphisms in Booroola (FecB), Galway (FecX G ), Inverdale (FecX I ) and Calpastatin (CAST) genes in Sakiz sheep. A total of 71 ewes were genotyped for gene or allelic polymorphisms in the genes listed above using the PCR-RFLP method. The results obtained from this study indicated that all of the Sakiz ewes sampled were non-carriers for FecB, FecX G or FecX I mutations. However, genotypic frequencies in the CAST gene were 0.59, 0.36 and 0.05 for AA, AB and BB, respectively. A significant deviation from Hardy-Weinberg equilibrium for the CAST gene was not observed in the investigated breed (P>0.05). As a result, more extensive screening is required as tests for newly discovered mutations are developed. Additionally, this study is the first to report a genetic polymorphism in the CAST gene in Sakiz sheep.

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Section: Discussionmentioning

confidence: 94%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Sakız Irkı Koyunlarda FecB, BMP15 ve CAST Genlerindeki Mutasyonların Analizi

Dinçel¹,

Ardıçlı²,

Soyudal³

et al. 2015

Kafkas Univ Vet Fak Derg

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“…The genotypes of FecB gene in ewes have been classified as homozygous noncarriers (++), with the ovulation rate of two or less; heterozygous carriers (B+), with the ovulation rate of three to four; and homozygous carriers (BB), with more than five ovulations per estrous cycle (5,6). FecB mutation was present in many sheep breeds, such as Booroola Merino (Australia) (1,4), Garole (India) (7), Javanese (Indonesia) (7), Kendrapada (India) (8), Bonpala (India) (9), Kalehkoohi (Iran) (10), Small Tail Han (China) (11,12), Hu (China) (12,13), prolific strains of Chinese Merino (China) (14), Duolang (China) (15), Cele (China) (16), Wadi (China) (17), Altay (China) (18), and Bayanbulak sheep (China) (19). Now the FecB is one of most important fecundity markers widely used in sheep breeding.…”

Section: Introductionmentioning

confidence: 99%

The genetic diversity of both FecB gene and microsatellite GC101is associated with reproduction selection in sheep

Pan¹,

Zhang²,

Hu³

et al. 2015

Turk J Vet Anim Sci

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cycle (5,6). FecB mutation was present in many sheep breeds, such as Booroola Merino (Australia) (1,4), Garole (India) (7), Javanese (Indonesia) (7), Kendrapada (India) (8), Bonpala (India) (9), Kalehkoohi (Iran) (10), Small Tail Han (China) (11,12), Hu (China) (12,13), prolific strains of Chinese Merino (China) ( 14), Duolang (China) (15), Cele (China) (16), Wadi (China) (17), Altay (China) (18), and Bayanbulak sheep (China) (19). Now the FecB is one of most important fecundity markers widely used in sheep breeding. However, in ancient times, our ancestors selected and improved sheep reproductive performance according to phenotypic characters. Microsatellite GC101 links with the prolificacy gene, and its genetic diversity might reveal the reproduction selection that happened in the past years. Information on GC101 is scant. Guan et al. (20) found low genetic diversity (200/200 bp, 200/238 bp) of GC101 present in Hu sheep. Small Tail Han sheep and Hu sheep are excellent local breeds in China for their significant characteristics of hyperprolificacy and year-round estrus. The mean live litter sizes of Small Tail Han, Hu, Dorset, and Texel sheep have been reported to be 2.61, 2.29 (21), 1.45, and

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Polymorphisms of coding region of BMPR-IB gene and their relationship with litter size in sheep

et al. 2010

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The bone morphogenetic protein receptor IB (BMPR-IB) was studied as a candidate gene for the prolificacy of sheep. Nine pairs of primers (P1-P9) were designed to detect single nucleotide polymorphisms (SNPs) of exons 1-4 and 6-10 of the BMPR-IB gene in both high (Small Tail Han and Hu sheep) and low prolificacy breeds (Texel and Chinese Merino sheep) by polymerase chain reaction (PCR)-single strand conformation polymorphism (SSCP). Only the products amplified by primers P2, P5, P6, P7, P8 and P9 displayed polymorphisms. The present study identified 22 SNPs in partial coding regions of ovine BMPR-IB, in which 20 SNPs were reported for the first time. In total of the 22 mutations, 18 DNA variations were originated from the Hu breed, three were found in the Small Tail Han breed (two of them were found in other sheep breeds), three in the Chinese Merino breed, and none in the Texel breed. These results preliminarily demonstrated that BMPR-IB is a major gene affecting the hyperprolificacy in Small Tail Han and Hu sheep, and could be used as a molecular genetic marker for early auxiliary selection for hyperprolificacy in sheep.

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Screening for Booroola (FecB) and Galway (FecXG) mutations in Indian sheep

Cited by 38 publications

References 25 publications

Sakız Irkı Koyunlarda FecB, BMP15 ve CAST Genlerindeki Mutasyonların Analizi

Sakız Irkı Koyunlarda FecB, BMP15 ve CAST Genlerindeki Mutasyonların Analizi

The genetic diversity of both FecB gene and microsatellite GC101is associated with reproduction selection in sheep

Polymorphisms of coding region of BMPR-IB gene and their relationship with litter size in sheep

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