Screening for Asymptomatic Bacteriuria in Pregnancy

McIsaac, Warren J.; Carroll, June C.; Biringer, Anne; Bernstein, Paul S.; Lyons, Elliott; Low, Donald E.; Permaul, Joanne A.

doi:10.1016/s1701-2163(16)30167-0

Cited by 55 publications

(46 citation statements)

References 19 publications

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“…Asymptomatic bacteriuria occurs in 2-10% of all pregnancies [1]. The prevalence has remained constant and most of the recent observational studies, including those from developing countries, report similar rates [12][13][14][15][16][17][18]. There is a paucity of literature on cystitis in pregnancy and an accurate prevalence is difficult to obtain.…”

Section: Epidemiologymentioning

confidence: 99%

Asymptomatic bacteriuria and symptomatic urinary tract infections in pregnancy

Schnarr

Smaill

2008

Eur J Clin Investigation

267

255

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Symptomatic and asymptomatic bacteriuria is common in pregnant women. A history of previous urinary tract infections and low socioeconomic status are risk factors for bacteriuria in pregnancy. Escherichia coli is the most common aetiologic agent in both symptomatic and asymptomatic infection and quantitative culture is the gold standard for diagnosis. Treatment of asymptomatic bacteriuria has been shown to reduce the rate of pyelonephritis in pregnancy and therefore screening for and treatment of asymptomatic bacteriuria has become a standard of obstetrical care. Antibiotic treatment of asymptomatic bacteriuria is associated with a decrease in the incidence of low birth weight, but the methodological quality of the studies limits the strength of the conclusions that can be drawn. Debate exists in the literature as to whether treated pyelonephritis is associated with adverse fetal outcomes. There is no clear consensus in the literature on antibiotic choice or duration of therapy for infection. With increasing antibiotic resistance, consideration of local resistance rates is necessary when choosing therapy.

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Section: Epidemiologymentioning

confidence: 99%

Asymptomatic bacteriuria and symptomatic urinary tract infections in pregnancy

Schnarr

Smaill

2008

Eur J Clin Investigation

267

255

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“…Pregnant women with asymptomatic bacteriuria should receive antibiotic therapy directed at the cultured organism and followup monitoring. The screening intervals must be between 12 to 16 weeks' gestation or at the first pre-natal visit, if later, although there is no consensus in the literature as to the optimal timing and screening frequency for asymptomatic bacteriuria (McIsaac et al, 2005;Tugrul et al, 2005;Schnarr & Smaill, 2008).…”

Section: Utis and Perinatal Outcomesmentioning

confidence: 99%

Urinary Tract Infections During Pregnancy

Berard¹,

Santos²,

Ferreira³

et al. 2011

Urinary Tract Infections

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“…McIsaac et al, demonstrated that the single urine culture before 20weeks of gestation leaves more than half of the ASB cases undiagnosed since 40.8% ASB positives were made after 1 st culture vs 63.3% after second vs 87.9% after the third culture. 32 Similarly, the prevalence distribution of ASB in the first, second, and third trimesters was 0.9%, 1.83%, and 5.6%, respectively in another study. 33 In our study also, the prevalence distribution of culture positive cases differed among trimesters suggesting that several women without bacteriuria in the first trimester may develop bacteriuria during the later stages of gestation.…”

Section: Discussionmentioning

confidence: 76%

“…31 However, the current studies suggest that performing the urine culture in all three trimesters improve the detection rate of ASB. 32 It was identified from various studies that ASB prevalence varies from trimester to trimester. McIsaac et al, demonstrated that the single urine culture before 20weeks of gestation leaves more than half of the ASB cases undiagnosed since 40.8% ASB positives were made after 1 st culture vs 63.3% after second vs 87.9% after the third culture.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of asymptomatic bacteriuria among antenatal women and its effects on maternal and perinatal outcome in northern Andhra Pradesh population

et al. 2018

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INTRODUCTIONAsymptomatic bacteriuria (ASB) is a condition in which urine culture reveals a significant growth of pathogenic bacteria i.e. greater than 105 bacteria/mL without the presence of symptoms related to urinary tract infection (UTI).1 The pregnant women are more commonly affected than non-pregnant women due to various morphological, physiological changes and urinary stasis that occur during pregnancy due to the effect of progesterone. 2 The prevalence of ASB in pregnant women varies from 4% to 23.9% globally and the higher prevalence is attributed to lack of personal and environmental hygiene, socio-economic status, parity and ABSTRACT Background: The pregnant women are more commonly affected with asymptomatic bacteriuria (ASB) than nonpregnant women and its progression could lead to adverse maternal and perinatal outcomes. The study was designed with an aim to know the prevalence of ASB and its effects on maternal and perinatal outcome. Methods: In this prospective study, 300 antenatal women attending Anil Neerukonda Hospital were screened for ASB. Urine culture was performed using standardized Kirby-Bauer disc diffusion method on blood agar, Mac Conkey's agar for antibiotic sensitivity testing. The screened antenatal women were divided into two subgroups viz. asymptomatic bacteriuria positive (Group I) and asymptomatic bacteriuria negative (Group II) depending on the culture study and were followed till delivery for maternal and perinatal outcomes. Results: The prevalence of ASB was 11.33%. Out of 34 cases of ASB positive, 8 cases (23.5%) were delivered with birth weight <2500 grams as compared to 11 cases (4.1%) in unexposed cases (RR 5.68, 95% CI; 2.46-13.15; p<0.05). Preterm low birth was noticed in 5 (14.7%) cases of ASB positive pregnant women with compared to unexposed cases (RR 1.5, 95% CI; 0.61-3.65, p=0.36). Regarding maternal outcomes, premature labour was observed in 8 cases (23.5%) of ASB exposed women whereas 22 (8.3%) in non-exposed cases (RR 2.84, 95% CI; p=0.004). A significant number of women have developed hypertension (17.6%) and preeclampsia (8.8%) in ASB positive cases as compared to ASB negative cases (4.9% and 2.3% respectively). Conclusions: The prevalence of ASB was 11.33% in the present study. As one third of the cases were identified in early and late trimesters, regular and trimester wise screening need to be incorporated in routine antenatal screening for safe motherhood and new born health.

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Screening for Asymptomatic Bacteriuria in Pregnancy

Cited by 55 publications

References 19 publications

Asymptomatic bacteriuria and symptomatic urinary tract infections in pregnancy

Asymptomatic bacteriuria and symptomatic urinary tract infections in pregnancy

Urinary Tract Infections During Pregnancy

Prevalence of asymptomatic bacteriuria among antenatal women and its effects on maternal and perinatal outcome in northern Andhra Pradesh population

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