Screening for and Genotyping of Human Papilloma Virus in Prostitutes

Abstract

A AB BS ST TR RA AC CT T OOb bj je ec ct ti iv ve e: : The human papilloma virus (HPV) causes various infectious clinical pictures and anogenital cancers, and it is recognized as the primary etiological agent of cervical cancer worldwide. In this study, we aimed to demonstrate the presence of HPV in prostitutes and to identify its genotypes in cervical specimens. M Ma at te er ri ia al l a an nd d M Me et th ho od ds s: : This study included 137 commercial sex workers from Ankara brothels who were referred to the Ankara Municipality Hospital, Department of Venereal Diseases from September 3-7, 2007 for routine examinations and who volunteered to participate. After obtaining informed consent from the participants, one-on-one interviews were conducted to obtain sociodemographic data. Cervical specimens were collected from each subject in order to investigate HPV genotypes by DNA extraction. R Re es su ul lt ts s: : The tests for HPV DNA were positive in 53 specimens following the extraction of DNA from swab specimens collected from the prostitutes. Seven cases had genotypes associated with the low-risk cancer group, one had genotypes affiliated with the undetermined risk group, and 38 had genotypes related to the high-risk group. In addition, genotypes associated with more than one risk group were detected in seven other study participants. Four subjects had genotypes related to both the undetermined indefinite and high-risk groups, two had genotypes connected with the low and high-risk groups, and one had genotypes from all three risk groups. Eighty-four participants tested negative for HPV DNA. C Co on nc cl lu us si io on n: : Women working in brothels are at risk for venereal diseases. This should be considered to protect both their own health and public health. It is noteworthy that the genotypes of HPV identified in the prostitutes were predominately of the high-risk cancerous type. Therefore, information regarding HPV should be distributed to women working in the sex industry, and preventive measures should be implemented to protect them from acquiring HPV. K Ke ey y W Wo or rd ds s: : Sexually transmitted diseases; community health planning Ö ÖZ ZE ET T A Am ma aç ç: : İnsan papillomavirüsleri [Human Papilloma Virüsü (HPV)] çesitli enfeksiyöz tablolara ve anogenital kanserlere neden olmaktadır. HPV bütün dünyada servikal kanserin primer etiyolojik etkeni olarak kabul edilmektedir. Bu çalışmadaki amaç, genelev kadınlarında, servikal örnekler kullanılarak, HPV varlığını ve genotiplerini ortaya koymaktır. G Ge er re eç ç v ve e Y Yö ön nt te em ml le er r: : 3-7 Eylül 2007 tarihleri arasında Ankara Belediye Hastanesi Zührevi Hastalıklar Bölümü'ne rutin muayeneleri yapılmak üzere başvuran Ankara Genelevleri'nde çalışan 137 genelev kadını çalışmaya gönüllü olarak katılmıştır. Aydınlatılmış onamları alındıktan sonra çal-ışma grubu ile sosyodemografik veriler ile ilgili bilgi edinmek amacıyla birebir görüşme yapılmıştır. Olgulardan servikal sürüntü örnekleri alınarak bu örneklerde 21 tür HPV DNA'sının genotipi ar...

Prevalence and Genotype Distribution of Genital Human Papillomavirus Infection in Female Sex Workers in the World: A Systematic Review and Meta-Analysis

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