Abstract:Background: Attention-deficit/hyperactivity disorder (ADHD) is a disabling disorder. High rates of ADHD have been consistently reported among prisoners. The main objectives were (1) to estimate the prevalence of ADHD symptoms in a sample of male inmates and (2) to investigate the relationship between ADHD symptoms and socio-demographic/clinical features. According to the high prevalence of childhood trauma among inmates, we assessed whether exposition to childhood trauma can be related to the presence of ADHD … Show more
“…Of the 32 studies comparing the prevalence of comorbid psychiatric disorder between subjects with and without adult ADHD, according to our classification criteria, 11 studies involved general populations, 18 studies included psychiatric populations, and three studies focused on incarcerated populations. One of the three studies dealing with incarcerated populations involved only female inmates [23], and the other one study involved only male inmates [24].…”
Comorbid psychiatric disorders in adults with ADHD are important because these comorbidities might complicate the diagnosis of ADHD and also worsen the prognosis. However, the prevalence of comorbid psychiatric disorders in adult ADHD varies according to the diagnostic tools used and the characteristics of target populations. The purpose of this review was to describe the prevalence of comorbid psychiatric disorders in adults with ADHD compared with adults without ADHD. Thirty-two studies published before August 2022 were identified and classified according to diagnosis of other psychiatric disorder in those with ADHD. The most frequent comorbid psychiatric disorder in the ADHD group was substance use disorder (SUD), followed by mood disorders, anxiety disorders, and personality disorders. The prevalence of these four disorders was higher in the ADHD group, whether or not subjects were diagnosed with other psychiatric disorders. In addition, the diversity of ADHD diagnostic tools was observed. This also might have affected the variability in prevalence of comorbidities. Standardization of ADHD diagnostic tools is necessary in the future.
“…Of the 32 studies comparing the prevalence of comorbid psychiatric disorder between subjects with and without adult ADHD, according to our classification criteria, 11 studies involved general populations, 18 studies included psychiatric populations, and three studies focused on incarcerated populations. One of the three studies dealing with incarcerated populations involved only female inmates [23], and the other one study involved only male inmates [24].…”
Comorbid psychiatric disorders in adults with ADHD are important because these comorbidities might complicate the diagnosis of ADHD and also worsen the prognosis. However, the prevalence of comorbid psychiatric disorders in adult ADHD varies according to the diagnostic tools used and the characteristics of target populations. The purpose of this review was to describe the prevalence of comorbid psychiatric disorders in adults with ADHD compared with adults without ADHD. Thirty-two studies published before August 2022 were identified and classified according to diagnosis of other psychiatric disorder in those with ADHD. The most frequent comorbid psychiatric disorder in the ADHD group was substance use disorder (SUD), followed by mood disorders, anxiety disorders, and personality disorders. The prevalence of these four disorders was higher in the ADHD group, whether or not subjects were diagnosed with other psychiatric disorders. In addition, the diversity of ADHD diagnostic tools was observed. This also might have affected the variability in prevalence of comorbidities. Standardization of ADHD diagnostic tools is necessary in the future.
“…Moreover, information for other variables were lacking, including mean monthly dosage for each LAI antipsychotic, reasons for prescribing LAI antipsychotics, previously administered antipsychotic medications (including the type of previous LAI antipsychotic), age at onset, duration of illness and the presence of other comorbid psychiatric diagnoses (Barbui et al ., 2020; Pelizza et al ., 2022; Auxilia et al ., 2023). Nevertheless, other factors that may be associated with the type of prescribed LAI antipsychotic, including migration (Bani-Fatemi et al ., 2019), living in rural or urban communities (Teplin, 1990; Peritogiannis et al ., 2023) and comorbid neurodevelopmental disorders (such as autism spectrum disorder and attention deficit-hyperactivity disorder) (Iasevoli et al ., 2020; Capuzzi et al ., 2022) were not evaluated in this study for lack of reliable information. Fifth, most of the data is based on self-report, increasing the risk of recall bias and skewed self-presentation.…”
Information on patterns of prescription of long-acting injection (LAI) antipsychotics among people who are incarcerated is lacking. Therefore, we aimed to evaluate prescribing rates for first-generation antipsychotic (FGA)-LAI versus second-generation antipsychotic (SGA)-LAI and to identify the factors associated with the prescription of one of the two classes of LAI. A cross-sectional study was conducted among incarcerated adult males hosted in Monza detention center between January 2013 and April 2023. Socio-demographic and clinical data were retrospectively collected. Descriptive and univariate statistics as well as logistic regression analyses were performed. Data were available for 135 consecutive incarcerated adult males with different mental disorders who received a LAI as part of their treatment. 75.6% of our sample was treated with FGA-LAIs, with haloperidol as the most commonly prescribed drug, followed by zuclopentixol and aripiprazole. Diagnosis of bipolar disorder and concomitant administration of antidepressants were statistically significant predictors of SGA-LAI prescription. Some patients’ characteristics may influence prescription patterns in prison. Further longitudinal studies with larger samples should confirm these findings.
“…In this regard, Cupertino et al [ 58 ] reported that the G allele of rs2251214 may be related to an earlier onset of impairment due to ADHD symptoms, higher incidence of behavioral problems, and comorbid antisocial personality disorder. Nevertheless, it is noteworthy that personality disorders may be predictors of poor outcomes in ADHD and limited response to MPH [ 5 , 59 ]. Thus, we cannot completely exclude a shared genetic risk factors among ADHD and personality disorders, which are, in turn, associated with poor outcomes [ 31 ].…”
Section: Discussionmentioning
confidence: 99%
“…However, studies regarding the long-term prognosis of adult ADHD patients are lacking. Further studies with larger samples, taking into account the three presentations of the disorder (predominantly inattentive, predominantly hyperactive-impulsive, and combination) and other environmental or biological factors are needed to have a complete overview of this topic [ 5 , 82 ].…”
Section: Discussionmentioning
confidence: 99%
“…On the other hand, some patients receive a new diagnosis of ADHD during adulthood [ 4 ]. It should be highlighted that the management of ADHD in adulthood is essential to prevent poor clinical and functional outcomes associated with this condition, even if comorbidities are treated [ 5 ].…”
Background: Attention-deficit/hyperactivity disorder (ADHD) is a highly prevalent condition with onset in childhood and in many cases persisting into adulthood. Even though an increasing number of studies have investigated the efficacy of pharmacotherapy in the management of adult ADHD, few authors have tried to identify the biological predictors of treatment response. Objectives: To summarize the available data about the biological markers of treatment response in adults affected by ADHD. Methods: A search on the main biomedical and psychological archives (PubMed, Embase, Scopus, and PsycINFO) was performed. Manuscripts in English, published up to May 2022 and having the biological predictors of treatment response in adults with ADHD as their main topic, were included. Results: A total of 3855 articles was screened. Twenty-two articles were finally included. Most of the manuscripts studied neuroimaging and electrophysiological factors as potential predictors of treatment response in adult ADHD patients. No reliable markers were identified until now. Promising findings on this topic regard genetic polymorphisms in snap receptor (SNARE) proteins and default mode network-striatum connectivity. Conclusions: Even though some biological markers seem promising for the prediction of treatment response in adults affected by ADHD, further studies are needed to confirm the available data in the context of precision medicine.
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