Screening for Abnormal Blood Glucose and Type 2 Diabetes Mellitus: U.S. Preventive Services Task Force Recommendation Statement

Siu, Albert L.

doi:10.7326/m15-2345

Cited by 271 publications

(202 citation statements)

References 44 publications

Supporting

Mentioning

197

Contrasting

Unclassified

Order By: Relevance

“…However, HbA 1c levels may have a role in SCD risk stratification and prevention in DM patients and other recognized high risk subsets of the population in whom such testing is clinically indicated and often available. 27 Our subgroup analyses directly support the concept that HbA 1c levels may be utilized to identify DM patients at higher risk for SCD. Based upon recent developments, SCD risk stratification in DM patients has potential clinical significance.…”

Section: Discussionsupporting

confidence: 67%

Hemoglobin A1c levels and risk of sudden cardiac death: A nested case-control study

et al. 2017

View full text Add to dashboard Cite

Background Sudden cardiac death (SCD) is often the first manifestation of cardiovascular disease (CVD) and preventive strategies within this broad population are lacking. Patients with diabetes represent a high risk subgroup, but few data exist regarding whether measures of glycemia mediate risk and/or add to SCD risk stratification. Objective Examine the association between hemoglobin A1c (HbA1c) and SCD. Methods We performed a case-control analysis among individuals enrolled in 6 prospective cohort studies. HbA1c levels were determined for 482 cases of SCD and 914 matched controls. Conditional logistic regression with fixed effects meta-analysis was used for analysis. Results In multivariable models, HbA1c levels were linearly associated with SCD risk over a follow-up of 11.3 years (P<0.001). Each 1% increment in HbA1c was associated with a hazard ratio (HR) of 1.32 (95% CI 1.16–1.50). The magnitude of the association was greater in subjects without versus with known CVD [HR per 1% increment 1.64 (95% CI 1.31–2.06) versus 1.15 (95% CI 0.99–1.33); P interaction = 0.009]. In models simultaneously controlling for diabetes status and HbA1c, the association between HbA1c and SCD remained significant (HR 1.29; 95% CI 1.07–1.55, P=0.01); whereas the association between diabetes and SCD was attenuated (RR 1.21, 95% CI 0.64–2.27, P=0.56). Conclusions In these prospective cohorts, HbA1c levels associated with SCD risk, particularly among those without known CVD, even after controlling for diabetes status. These data support the hypothesis that hyperglycemia mediates SCD risk among patients with diabetes.

show abstract

Section: Discussionsupporting

confidence: 67%

Hemoglobin A1c levels and risk of sudden cardiac death: A nested case-control study

et al. 2017

View full text Add to dashboard Cite

show abstract

“…Screening and early treatment for diabetes appear to be associated with limited harms [6,7]. Health check programmes including diabetes risk assessment have been proposed or introduced in a number of countries [8,9]. However, trials of population-based screening for type 2 diabetes [10] and related cardiovascular risk factors [11] have failed to show significant overall benefit.…”

Section: Introductionmentioning

confidence: 99%

Effect of screening for type 2 diabetes on risk of cardiovascular disease and mortality: a controlled trial among 139,075 individuals diagnosed with diabetes in Denmark between 2001 and 2009

et al. 2017

View full text Add to dashboard Cite

Aims/hypothesis There is continuing debate about the net benefits of population screening for type 2 diabetes. We compared the risk of cardiovascular disease (CVD) and mortality among incident cases of type 2 diabetes in a screened group with those in an unscreened group. Methods In this register-based non-randomised controlled trial, eligible individuals were all men and women aged 40-69 years without known diabetes, registered with a general practice in Denmark (n = 1,912,392). Conclusions/interpretation A single round of diabetes screening and cardiovascular risk assessment in middle-aged Danish adults in general practice was associated with a significant reduction in risk of all-cause mortality and CVD events in those diagnosed with diabetes.

show abstract

“…In addition, 86 million American adults have pre-diabetes, a condition in which blood glucose is elevated and increases the risk of developing diabetes [3,4]. Since it has been demonstrated that intervening with people at high risk for diabetes can prevent or delay the onset of diabetes [5], the American Diabetes Association [6] and other organizations [7][8][9] recommend such interventions for those with pre-diabetes. Widespread adoption of screening to detect and manage pre-diabetes is desirable, but effective ways to increase adoption of such recommendations by providers in primary care practices have yet to be fully explored.…”

Section: Introductionmentioning

confidence: 99%

Primary Care Provider Feedback of Training to Identify and Manage Pre-Diabetes

Sohler¹,

Zubatov²,

Sill³

et al. 2017

J Community Med Health Educ

View full text Add to dashboard Cite

show abstract

Screening for Abnormal Blood Glucose and Type 2 Diabetes Mellitus: U.S. Preventive Services Task Force Recommendation Statement

Cited by 271 publications

References 44 publications

Hemoglobin A1c levels and risk of sudden cardiac death: A nested case-control study

Hemoglobin A1c levels and risk of sudden cardiac death: A nested case-control study

Effect of screening for type 2 diabetes on risk of cardiovascular disease and mortality: a controlled trial among 139,075 individuals diagnosed with diabetes in Denmark between 2001 and 2009

Primary Care Provider Feedback of Training to Identify and Manage Pre-Diabetes

Contact Info

Product

Resources

About