Screening, Deconvolution and Parallel Synthesis of Trisubstituted
Piperazine and Trisubstituted 2,3-diketopierazine Libraries for the Rapid
Identification of Antagonists of the Nuclear Retinoic Acid Receptor-related
Orphan Receptor Gamma (RORγ)
Abstract:Background:
Genetic studies support a key role for RORγ and RORα in the differentiation of proinflammatory Th17 cells, and a growing body of evidence suggests a pathogenic role for Th17 in several autoimmune diseases, including MS, rheumatoid arthritis, inflammatory bowel disease, type I diabetes, and psoriasis. RORγ antagonists have been shown to suppress Th17 differentiation and delay the onset of disease in an experimental autoimmune encephalomyelitis mouse model of MS.
Objective:
Given the high therapeut… Show more
Set email alert for when this publication receives citations?
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.