Screening compounds against HCV based on MAVS/IFN-β pathway in a replicon model

Fu, Qiuxia; Wang, Li-Cui; Jia, Shuaizheng; Gao, Bo; Zhou, Yong; Du, Juan; Wang, Yingli; Wang, Xiaohui; Peng, Jianchun; Li, Zhan

doi:10.3748/wjg.v16.i44.5582

Cited by 1 publication

(1 citation statement)

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“…The NS3/4A protein also blocks RLH signaling by directly cleaving MAVS at Cys-508, displacing it from the OMM [3,102,103]. Notably, current screenings for new HCV therapeutics are targeting this mitochondria-localized phenomenon of MAVS cleavage, and the virus’ ability to overcome innate immune recognition from host cells [104]. …”

Section: Mitochondrial Innate Immune Signalingmentioning

confidence: 99%

Viral Product Trafficking to Mitochondria, Mechanisms and Roles in Pathogenesis

Williamson¹,

DeBiasi²,

Colberg-Poley³

2012

IDDT

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A wide variety of viruses cause significant morbidity and mortality in humans. However, targeted antiviral therapies have been developed for only a subset of these viruses, with the majority of currently licensed antiviral drugs targeting viral entry, replication or exit steps during the viral life cycle. Due to increasing emergence of antiviral drug resistant viruses, the isolation of multiple viral subtypes, and toxicities of existing therapies, there remains an urgent need for the timely development of novel antiviral agents, including those targeting host factors essential for viral replication. This review summarizes viral mitochondrial products and their effects on common mitochondria regulated pathways. These viral products and the mitochondrial pathways affected by them provide potential novel targets for the rational design of antiviral drugs. Viral products alter oxidative balance, mitochondrial permeability transition pore, mitochondrial membrane potential, electron transport and energy production. Moreover, viruses may cause the Warburg Effect, in which metabolism is reprogrammed to aerobic glycolysis as the main source of energy. Finally, viral products affect proapoptotic and antiapoptotic signaling, as well as mitochondrial innate immune signaling. Because of their importance for the generation of metabolic intermediates and energy as well as cell survival, mitochondrial pathways are targeted by multiple independent viral products. Structural modifications of existing drugs targeted to mitochondrial pathways may lead to the development of novel antiviral drugs with improved efficacy and reduced toxicity.

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