Screening combinatorial libraries of molecularly imprinted polymer films casted on membranes in single-use membrane modules

Synthesis and Characterization of Molecularly Imprinted Polymer Membrane for the Removal of 2,4-Dinitrophenol

“…To date, their most extensively investigated application has been as separation materials for the analysis of various compounds, including drugs [16,17], pesticides [18,19], and amino acids [20]. A highly specific detection technology, MIPs have been used for the separation of isomers and enantiomers [21], solid extraction [22], in biochemical sensors [23] and chemosensors [24], in simulating enzyme-catalysed pharmaceutical analysis [25], in sorbents, and in membrane separation technologies [26]. They have been prepared in various configurations—including polymer beads, monoliths, and membranes—and have numerous advantages, such as physical robustness, high strength, resistance to elevated temperatures and pressures, and inertness towards organic solvents, acids, and bases [27].…”

Influence of salt ions on binding to molecularly imprinted polymers

“…More recently, several promising methods to approach the optimization problem in a more systematic way have been demonstrated. Chemometrical approaches, combinatorial synthesis, high-throughput screening, and computational methods have been applied to investigate factors of importance in the synthesis protocol and to expedite the optimization of polymer compositions towards high selective rebinding of the template [4][5][6][7][8][9][10][11][12][13][14][15].…”

Scintillation proximity assay in lead discovery

“…In this form, the MIP demonstrated an ability to determine binding affinity and specificity in sensing a target analyte and suggests supplementary applications to screening large combinatorial chemical libraries. Further developments in the design of MIP configurations either as thin films or membranes are being evaluated for the simultaneous assay of multiple samples and for the direct evaluation of drugs in biological fluids [51] . Along a different path, a membrane-soluble scintillant (MSS) possessing a 2,5-diphenyloxazole scintillant 'head' group attached to a lipophilic 'tail' group was shown to display scintillant properties in non-aqueous as opposed to aqueous environments.…”