Screening Colonoscopy, Colorectal Cancer and Gender: An Unfair Deal for the Fair Sex?

Singh, Gurkirpal; Gerson, Lauren B.; Wang, Huijian; Mannalithara, Ajitha; Mithal, Alka; Triadafilopoulos, George

doi:10.1016/j.gie.2007.03.068

Cited by 20 publications

(7 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In a case-control study in the California Medicaid population involving 4458 cancer cases and 43,815 controls, Singh et al 46 identified a 45% reduction in CRC incidence after colonoscopy (adjusted RR, 0.55; 95% CI, 0.46-0.65). Overall, the risk for right-sided tumors after negative colonoscopy was considerably higher (0.67) than that for left-sided tumors (0.16).…”

Section: Crc Incidence After Negative Colonoscopymentioning

confidence: 99%

Does Colonoscopy Work?

Hewett¹,

Kahi²,

Rex³

2010

J Natl Compr Canc Netw

View full text Add to dashboard Cite

Through its impact on the adenoma-carcinoma sequence, colonoscopy has a central role in the detection and prevention of colorectal cancer (CRC). Observational data support a protective effect of colonoscopy and polypectomy on CRC incidence and mortality. However, recent studies suggest that the degree of CRC protection afforded by colonoscopy is dependent on the effectiveness of identification of prevalent cancers or their precursors, particularly in the proximal colon. Biologic variation in tumor genetics and growth likely contribute to diminished protection in the proximal colon. Operator variability is known to be a key factor predicting adenoma detection. Evidence supports the immediate adoption of specific quality improvement initiatives to reduce the failure rate of colonoscopy. Further interventions should target individual, organizational, and health system factors which influence physician behavior.

show abstract

Section: Crc Incidence After Negative Colonoscopymentioning

confidence: 99%

Does Colonoscopy Work?

Hewett¹,

Kahi²,

Rex³

2010

J Natl Compr Canc Netw

View full text Add to dashboard Cite

show abstract

“…This finding may have clinical importance, given recent studies that found that colonoscopy is not as protective in the right side of the colon as it is in the left side of the colon. 14,28 This study has multiple limitations. First, the study colonoscopists were obviously not blinded to the presence of the TER.…”

Section: Discussionmentioning

confidence: 98%

A retrograde-viewing device improves detection of adenomas in the colon: a prospective efficacy evaluation (with videos)

Waye

Heigh

Fleischer

et al. 2010

Gastrointestinal Endoscopy

106

View full text Add to dashboard Cite

“…The results of several observational studies and clinical trials call into question this assumption, suggesting that both sigmoidoscopy and colonoscopy are associated with substantially decreased risks of rectal and distal colon cancer, but they may not modify the risk of proximal colon cancer (4–10). Other studies show reductions in both distal and proximal colon cancer associated with colonoscopy, but report larger effects in the distal colon (11, 12)…”

Section: Introductionmentioning

confidence: 91%

Colorectal Endoscopy, Advanced Adenomas, and Sessile Serrated Polyps: Implications for Proximal Colon Cancer

Burnett‐Hartman

Newcomb

Phipps

et al. 2012

American Journal of Gastroenterology

View full text Add to dashboard Cite

OBJECTIVES Colonoscopy is associated with a decreased risk of colorectal cancer but may be more effective in reducing the risk of distal than proximal malignancies. To gain insight into the differences between proximal and distal colon endoscopic performance, we conducted a case-control study of advanced adenomas, the primary targets of colorectal endoscopy screening, and sessile serrated polyps (SSPs), newly recognized precursor lesions for a colorectal cancer subset that occurs most often in the proximal colon. METHODS The Group Health-based study population included: 213 advanced adenoma cases, 172 SSP cases, and 1,704 controls ages 50–79, who received an index colonoscopy from 1998–2007. All participants completed a structured questionnaire covering endoscopy history. Participants with polyps underwent a standard pathology review to confirm the diagnosis and reclassify a subset as advanced adenomas or SSPs. Logistic regression analyses were conducted to estimate adjusted odds ratios (OR) and 95% confidence intervals (CI) for the association between endoscopy and advanced adenomas and SSPs separately; site-specific analyses were completed. RESULTS Previous endoscopy was associated with decreased risk of advanced adenomas in both the rectum/distal colon (OR=0.38; 95% CI: 0.26–0.56) and proximal colon (OR=0.31; 95% CI: 0.19–0.52), but there was no statistically significant association between prior endoscopy and SSPs (OR=0.80; 95%CI: 0.56–1.13). CONCLUSIONS Our results support the hypothesis that the effect of endoscopy differs between advanced adenomas and SSPs. This may have implications for proximal colon cancer prevention and be due to the failure of endoscopy to detect/remove SSPs, or the hypothesized rapid development of SSPs.

show abstract

Screening Colonoscopy, Colorectal Cancer and Gender: An Unfair Deal for the Fair Sex?

Cited by 20 publications

References 0 publications

Does Colonoscopy Work?

Does Colonoscopy Work?

A retrograde-viewing device improves detection of adenomas in the colon: a prospective efficacy evaluation (with videos)

Colorectal Endoscopy, Advanced Adenomas, and Sessile Serrated Polyps: Implications for Proximal Colon Cancer

Contact Info

Product

Resources

About