Screening children with severe short stature for celiac disease using tissue transglutaminase

Faraz, Ahmad; Alam, Seema; Shukla, Indu; Sherwani, Rana K; Ali, Syed S.

doi:10.1007/s12098-010-0040-2

Cited by 7 publications

(14 citation statements)

References 17 publications

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“…Our literature search retrieved 1162 article titles, of which 71 were found eligible for full‐text review and eligibility assessment. The eligibility criteria were fulfilled by 17 studies, and they were finally included in the systematic review and meta‐analysis 27–43 . The reasons for excluding the remaining studies are summarized in Figure 1.…”

Section: Resultsmentioning

confidence: 99%

“…All‐cause short stature was evaluated in six studies comprising 1582 patients, 28,33,36,39,40,43 while the remaining 11 studies included 2177 patients with idiopathic short stature 27,29–32,35,37,38,41,42,51 . In six studies evaluating idiopathic short stature, the respective investigators had biopsied all the screened patients 27,29,30,32,34,37 ; in the remaining 11 studies, patients underwent duodenal biopsies sequentially once they were found to be seropositive for CeD 28,31,33,35,36,38–43 . IgA AGA were used by three studies, 27,30,37 and the rest of the studies used anti‐tTG‐ab 28,29,33,34,40,41 or anti‐EMA 32,35,38,42 .…”

Section: Resultsmentioning

confidence: 99%

“…Three studies evaluating patients with all‐cause short stature reported the seroprevalence of CeD 28,33,43 . Of 469 patients included in the analysis, 61 were seropositive for CeD.…”

Section: Resultsmentioning

confidence: 99%

“…The eligibility criteria were fulfilled by 17 studies, and they were finally included in the systematic review and meta-analysis. [27][28][29][30][31][32][33][34][35][36][37][38][39][40][41][42][43] The reasons for excluding the remaining studies are summarized in Figure 1. In case of multiple publications by the same group of authors involving the same group of patients, 28,44 the paper with better quality and with detailed reporting of methods and results was included in the final analysis.…”

Section: Resultsmentioning

confidence: 99%

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Prevalence of celiac disease in patients with short stature: A systematic review and meta‐analysis

Singh

Farooqui

et al. 2020

J of Gastro and Hepatol

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Background and AimShort stature is a common extraintestinal manifestation of celiac disease (CeD). We conducted a systematic review and meta‐analysis to assess the global prevalence of CeD in patients presenting with short stature.MethodsWe searched Medline and EMBASE databases for the keywords “celiac disease, coeliac disease, anti‐gliadin, tissue transglutaminase antibody, anti‐endomysial antibody, short stature and growth retardation.” All the studies published from January 1991 to May 2020 were included. Patients without any prior evaluation for short stature were classified as all‐cause short stature, while prior evaluated patients, where no cause was found for short stature, were classified as idiopathic short stature. The diagnosis of CeD was based on the European Society for Paediatric Gastroenterology, Hepatology and Nutrition guidelines. A random‐effects model was used to pool the data.ResultsSeventeen studies screening 3759 patients (1582 with all‐cause short stature and 2177 with idiopathic short stature) were included. The pooled seroprevalence of CeD based on positive anti‐tissue transglutaminase antibody and anti‐endomysial antibody was 11.2% (95% CI 4.0–21.2%; I2 = 86%) and 9.7% (95% CI 2.7–20.2%; I2 = 95%) for all‐cause and idiopathic short stature, respectively. Similarly, pooled prevalence of biopsy‐confirmed CeD was 7.4% (95% CI 4.7–10.6%; I2 = 76%) and 11.6% (95% CI 4.1–22.2%; I2 = 97%), for all‐cause and idiopathic short stature, respectively. There was an overall severe risk of selection bias and significant heterogeneity in the pooled results.ConclusionsApproximately one in 14 patients with all‐cause short stature and one in nine patients with idiopathic short stature had biopsy‐confirmed CeD. Therefore, evaluation for CeD may be prudent in all patients with short stature.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

“…Three studies evaluating patients with all‐cause short stature reported the seroprevalence of CeD 28,33,43 . Of 469 patients included in the analysis, 61 were seropositive for CeD.…”

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 2 more Smart Citations

Prevalence of celiac disease in patients with short stature: A systematic review and meta‐analysis

Singh

Farooqui

et al. 2020

J of Gastro and Hepatol

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“…Other less common causes of short stature were metabolic bone disease, Turner syndrome, adrenal disorders, diabetes mellitus, and nutritional defi ciency. In previous studies done in India, its prevalence varied from 13.7 to 20.5 [18][19] . In the present study, the higher prevalence of CD in short statured children might be differences in the prevalence of CD in study populations.…”

Section: Discussionmentioning

confidence: 96%

Clinical and Nutritional Assessment of Short Statured Indian Children with Celiac Disease

Mali

Meena

Khatri

et al. 2013

J. Nepal Paedtr. Soc.

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Introduction: Celiac disease is an autoimmune disease, which is increasingly recognized as a cause of short stature in genetically susceptible population. The present study was undertaken to look for prevalence of celiac disease among the pediatric population with short stature (SS) and to study characteristics of these short statured children with celiac disease. Materials and Methods: This is a prospective study conducted at a tertiary teaching hospital at Bikaner, Rajasthan to look for the occurrence of celiac disease amongst the pediatric population (<15 years) with short stature (n=100). Other common causes of short stature were also identified. Results: Out of 100 short statured children, 38 (38%) had celiac disease and other major causes responsible were hypothyroidism, pituitary disorders, constitutional growth delay, and familial short stature. Chronic diarrhea, anorexia, anemia and behavioral changes were statistically more common in short statured children (<15 years) having celiac disease than non celiac patients. Conclusion: We conclude that celiac disease is not an uncommon cause of short stature and stunted growth in this region. All short statured patients should be screened for celiac disease. DOI: http://dx.doi.org/10.3126/jnps.v33i2.7912 J Nepal Paediatr Soc. 2013; 33(2):91-94

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Disorders of Growth

Grissom¹,

Ungar²,

Iroku‐Malize³

2020

The Encyclopedia of Child and Adolescent Development

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Children who are significantly (two or more standard deviations) below or above average height can be considered to be of short or tall stature, although it is more common for children and their parents to be concerned about short stature. Evaluation for a suspected growth disorder should involve standardized assessment to identify both normal (e.g., familial short or tall stature) and abnormal variants (e.g., a genetic disorder) of growth in order to determine etiology and guide intervention, including the decision not to intervene medically. Treatment should be based on the determined etiology of the tall or short stature and, for many children, medical treatment may not be necessary. Providing information to patients and their parents regarding the potential risks and benefits of treatment is essential in order to provide the best care, to reassure parents and families, and to manage expectations appropriately.

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Screening children with severe short stature for celiac disease using tissue transglutaminase

Abstract: More than one fifth of all severe short stature are seropositive for tTG and the chances of seropositivity increases if severe anemia and bulky stool are also associated.

Cited by 7 publications

References 17 publications

Prevalence of celiac disease in patients with short stature: A systematic review and meta‐analysis

Prevalence of celiac disease in patients with short stature: A systematic review and meta‐analysis

Clinical and Nutritional Assessment of Short Statured Indian Children with Celiac Disease

Disorders of Growth

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