Screening, characterization, and determination of suspected additives bimatoprost and latanoprost in cosmetics using NMR and LC–MS methods

Yong, Lu; He, Ying; Wang, Xinran; Wang, Haiyan; Qiu, Qianqian; Wu, Bian; Wu, Xianfu

doi:10.1007/s00216-023-04744-1

Cited by 4 publications

(3 citation statements)

References 40 publications

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“…Mass spectrometry (MS) identifies molecular mass and composition by measuring the trajectory of molecules in electric or magnetic fields, applicable to nearly all compounds and particularly suited for the qualitative and quantitative analyses of complex cosmetic components [ 128 ]. Nuclear magnetic resonance (NMR) leverages the absorption and emission of radio waves by atomic nuclei in an external magnetic field, applicable to organic compounds containing active nuclei (such as 1 H, 13 C), and is instrumental in analyzing the structure of complex organic compounds in cosmetics [ 129 ]. Gas chromatography (GC) employs gas as the mobile phase and separates components through a stationary phase in a chromatography column, ideal for volatile and thermally stable organic compounds like fragrances and solvents in cosmetics [ 130 ].…”

Section: Compositions and Representative Compounds Of Cosmeticsmentioning

confidence: 99%

“…It effectively extracts active ingredients from complex matrices while preserving the stability of thermosensitive substances. In 2023, Yong et al [ 129 ] applied UAE technology to process commercially available eyelash serums, followed by separation and purification using silica gel columns. Employing the Cosmetic Risk Substance Screening Platform, they detected suspicious components in two different fractions.…”

Section: Advances In Cosmetic Pretreatment Techniquesmentioning

confidence: 99%

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Decoding Cosmetic Complexities: A Comprehensive Guide to Matrix Composition and Pretreatment Technology

Du,

He,

Chen

et al. 2024

Molecules

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Despite advancements in analytical technologies, the complex nature of cosmetic matrices, coupled with the presence of diverse and trace unauthorized additives, hinders the application of these technologies in cosmetics analysis. This not only impedes effective regulation of cosmetics but also leads to the continual infiltration of illegal products into the market, posing serious health risks to consumers. The establishment of cosmetic regulations is often based on extensive scientific experiments, resulting in a certain degree of latency. Therefore, timely advancement in laboratory research is crucial to ensure the timely update and adaptability of regulations. A comprehensive understanding of the composition of cosmetic matrices and their pretreatment technologies is vital for enhancing the efficiency and accuracy of cosmetic detection. Drawing upon the China National Medical Products Administration’s 2021 Cosmetic Classification Rules and Classification Catalogue, we streamline the wide array of cosmetics into four principal categories based on the following compositions: emulsified, liquid, powdered, and wax-based cosmetics. In this review, the characteristics, compositional elements, and physicochemical properties inherent to each category, as well as an extensive overview of the evolution of pretreatment methods for different categories, will be explored. Our objective is to provide a clear and comprehensive guide, equipping researchers with profound insights into the core compositions and pretreatment methods of cosmetics, which will in turn advance cosmetic analysis and improve detection and regulatory approaches in the industry.

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Section: Compositions and Representative Compounds Of Cosmeticsmentioning

confidence: 99%

Section: Advances In Cosmetic Pretreatment Techniquesmentioning

confidence: 99%

Decoding Cosmetic Complexities: A Comprehensive Guide to Matrix Composition and Pretreatment Technology

Du,

He,

Chen

et al. 2024

Molecules

Self Cite

View full text Add to dashboard Cite

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“…The toxicological effects of these RSs on four different cell lines were then tested in an MTT assay [16] and the acute toxicity of RS1 and RS2 was assessed in vivo at a fixed-dose level (200 mg/kg) [17]. The results of these analyses, ultimately, revealed the stability of the developed approach to isolating and characterizing STHCl-associated RSs via HPLC, LC-MS, and NMR approaches [18,19], while also offering in vitro and in vivo evidence regarding the acute toxicity of two newly identified RSs.…”

Section: Introductionmentioning

confidence: 99%

HPLC and LC–MS/MS-Based Quantitative Characterization of Related Substances Associated with Sotalol Hydrochloride

Zhu,

Shen,

Wang

et al. 2024

Molecules

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In total, three related substances (RS) associated with sotalol hydrochloride (STHCl) were herein identified with a novel gradient high-performance liquid chromatography (HPLC) protocol. Further characterization of these substances was then performed via liquid chromatography–mass spectroscopy (LC–MS/MS) and nuclear magnetic resonance (NMR) approaches. For these analyses, commercial STHCl samples were used for quantitative HPLC studies and the degradation of STHCl under acidic (1M HCl), alkaline (1M NaOH), oxidative (30% H2O2), photolytic (4500 Lx), and thermal stress conditions (100 °C) was assessed. This approach revealed this drug to be resistant to acidic, alkaline, and high-temperature conditions, whereas it was susceptible to light and oxidation as confirmed through long-term experiments. The putative mechanisms governing RS formation were also explored, revealing that RS3 was derived from the manufacturing process, whereas RS2 was generated via oxidation and RS1 was generated in response to light exposure. The cytotoxicity of these RS compounds was then assessed using MTT assays and acute toxicity test. Overall, this study provides details regarding the characterization, isolation, quantification, and toxicological evaluation of STHCl and associated RS compounds together with details regarding the precise, specific, and reliable novel HPLC technique, thus providing the requisite information necessary to ensure STHCl purity and safety.

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HPLC-DAD method for concurrent estimation of netarsudil, latanoprost and benzalkonium chloride: Stability indicating study, impurity separation, assay of ophthalmic preparations and greenness/whiteness valuation

Ashour,

Korany,

Abdelhamid

et al. 2024

Microchemical Journal

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Screening, characterization, and determination of suspected additives bimatoprost and latanoprost in cosmetics using NMR and LC–MS methods

Cited by 4 publications

References 40 publications

Decoding Cosmetic Complexities: A Comprehensive Guide to Matrix Composition and Pretreatment Technology

Decoding Cosmetic Complexities: A Comprehensive Guide to Matrix Composition and Pretreatment Technology

HPLC and LC–MS/MS-Based Quantitative Characterization of Related Substances Associated with Sotalol Hydrochloride

HPLC-DAD method for concurrent estimation of netarsudil, latanoprost and benzalkonium chloride: Stability indicating study, impurity separation, assay of ophthalmic preparations and greenness/whiteness valuation

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