Screening Antimicrobial Activity of Nickel Nanoparticles Synthesized Using <i>Ocimum sanctum</i> Leaf Extract

Pandian, Chitra Jeyaraj; Rameshthangam, Palanivel; Dhanasekaran, Solairaj

doi:10.1155/2016/4694367

Cited by 54 publications

(26 citation statements)

References 33 publications

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“…Physically, nano‐Ni can damage skin, tissue/organ surfaces, cell walls, and internal membranes, presumably through production of ROS that disrupts structural integrity (Gallo et al 2016; Oukarroum et al 2017; Peng et al 2018) and leads to leakage of intracellular proteins across membranes into the extracellular medium (Jeyaraj Pandian et al 2016). Exposure to nano‐Ni can also lead to cell enlargement and aberrant cell morphology (Oukarroum et al 2017; Sousa et al 2018b), and it has even been reported to cause skeletal damage such as scoliosis in fish (Morgaleva et al 2017).…”

Section: Resultsmentioning

confidence: 99%

“…In addition, nano‐Ni can cause chemical damage. Nano‐Ni induces production or release of ROS inside of or external to organisms (Han et al 2012; Zhang et al 2013; Fu et al 2014; Oukarroum et al 2015, 2017; Jeyaraj Pandian et al 2016; Peng et al 2018; Sousa et al 2018a, 2018b, 2018c). This is a common mechanism of many metal‐containing NPs, leading to oxidative stress (Canesi et al 2019).…”

Section: Resultsmentioning

confidence: 99%

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Toxicity of Nanoparticulate Nickel to Aquatic Organisms: Review and Recommendations for Improvement of Toxicity Tests

Meyer¹,

Lyons-Darden²,

Garman³

et al. 2020

Enviro Toxic and Chemistry

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We reviewed the literature on toxicity of nanoparticulate nickel (nano-Ni) to aquatic organisms, from the perspective of relevance and reliability in a regulatory framework. Our main findings were 1) much of the published nano-Ni toxicity data is of low or medium quality in terms of reporting key physical-chemical properties, methodologies, and results, compared with published dissolved nickel studies; and 2) based on the available information, some common findings about nanoparticle (NP) toxicity are not supported for nano-Ni. First, we concluded that nanoparticulate elemental nickel and nickel oxide, which differ in chemical composition, generally did not differ in their toxicity. Second, there is no evidence that the toxicity of nano-Ni increases as the size of the NPs decreases. Third, for most organisms tested, nano-Ni was not more toxic on a mass-concentration basis than dissolved Ni. Fourth, there is conflicting evidence about whether the toxicity is directly caused by the NPs or by the dissolved fraction released from the NPs. However, no evidence suggests that any of the molecular, physiological, and structural mechanisms of nano-Ni toxicity differ from the general pattern for many metal-based nanomaterials, wherein oxidative stress underlies the observed effects. Physical-chemical factors in the design and conduct of nano-Ni toxicity tests are important, but often they are not adequately reported (e.g., characteristics of dry nano-Ni particles and of wetted particles in exposure waters; exposure-water chemistry).

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Toxicity of Nanoparticulate Nickel to Aquatic Organisms: Review and Recommendations for Improvement of Toxicity Tests

Meyer¹,

Lyons-Darden²,

Garman³

et al. 2020

Enviro Toxic and Chemistry

View full text Add to dashboard Cite

show abstract

“…Taking into account all these points, the most probable clinical use against bacterial infections of metal NPs would be restricted to topical or local use. Over the last few years, other element such as, nickel [ 165 , 166 ], cerium [ 166 , 167 ], Se [ 168 , 169 ], caesium [ 170 ], yttrium [ 171 ], palladium [ 172 , 173 ], or superparamagnetic Fe NPs [ 174 ] have been recently employed in the battle against antibiotic-resistant bacteria [ 21 , 125 ], but more studies that include cytotoxicity and biocompatibility are necessary.…”

Section: Nanoparticles and Human Infectionsmentioning

confidence: 99%

Inorganic and Polymeric Nanoparticles for Human Viral and Bacterial Infections Prevention and Treatment

2021

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Infectious diseases hold third place in the top 10 causes of death worldwide and were responsible for more than 6.7 million deaths in 2016. Nanomedicine is a multidisciplinary field which is based on the application of nanotechnology for medical purposes and can be defined as the use of nanomaterials for diagnosis, monitoring, control, prevention, and treatment of diseases, including infectious diseases. One of the most used nanomaterials in nanomedicine are nanoparticles, particles with a nano-scale size that show highly tunable physical and optical properties, and the capacity to a wide library of compounds. This manuscript is intended to be a comprehensive review of the available recent literature on nanoparticles used for the prevention and treatment of human infectious diseases caused by different viruses, and bacteria from a clinical point of view by basing on original articles which talk about what has been made to date and excluding commercial products, but also by highlighting what has not been still made and some clinical concepts that must be considered for futures nanoparticles-based technologies applications.

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“…Similarly, NiO nanoparticles biosynthesized from fresh leaves of the Neem plant have shown bacterial cell membrane disruption, which resulted in the death of bacterial cells (Helan et al, 2016). Moreover, the inhibition efficiency of bacterial growth was enhanced in the presence of amoxicillin together with Ni nanoparticles (Jeyaraj Pandian et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

Chemical Synthesis and Antipseudomonal Activity of Al-Doped NiO Nanoparticles

et al. 2021

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Synthesis of efficient antibacterial agents has become extremely important due to the emergence of antibiotic resistant bacteria. This is especially true for Pseudomonas aeruginosa, an opportunistic pathogen having ability to rapidly develop resistance to multiple classes of antibiotics thus limiting the efficacy of antibiotics approved for clinical use. Aluminum (Al)-doped NiO nanoparticles are of special interest due to their enhanced antipseudomonal properties at certain Al-doping levels. The composite hydroxide mediated (CHM) approach was opted for the synthesis of pure nickel oxide (NiO) and Al-doped nickel oxide (Ni1–xAlxO; x = 5, 10, 15, 20, 25, and 30 wt.%) nanoparticles. X-ray diffraction (XRD) technique was used for structural analysis of these nanoparticles. Morphology and elemental composition of these nanoparticles were investigated by scanning electron microscopy (SEM) and energy dispersive X-ray (EDX) spectroscopy, respectively. The optical properties were investigated by using UV-visible spectroscopy and Kubelka-Munk Theory and Tauc relation were employed for energy bandgap calculation of these nanoparticles. The antibacterial activity of representative Al-doped NiO nanoparticles was assessed on multidrug-resistant clinical P. aeruginosa strains. The agar well and disc-diffusion methods were used to assess the antibacterial efficacy of (Al)-doped NiO compared to pure NiO nanoparticles. Interestingly, a gradual increase in the antibacterial activity was observed with increasing Al-doping concentration and the highest antibacterial activity was observed at x = 15 wt.% Al-doping concentration. The antipseudomonal efficacy of Ni1–xAlxO nanoparticles was comparable to aztreonam antibiotic, primarily used for Gram-negative bacterial infections. Hence, it is proposed that these nanoparticles can be used for coating surgical devices, bone prostheses, medical implants, antibacterial clothing and in pharmaceutical formulations as burn ointments to produce the antimicrobial effect.

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Screening Antimicrobial Activity of Nickel Nanoparticles Synthesized Using Ocimum sanctum Leaf Extract

Cited by 54 publications

References 33 publications

Toxicity of Nanoparticulate Nickel to Aquatic Organisms: Review and Recommendations for Improvement of Toxicity Tests

Toxicity of Nanoparticulate Nickel to Aquatic Organisms: Review and Recommendations for Improvement of Toxicity Tests

Inorganic and Polymeric Nanoparticles for Human Viral and Bacterial Infections Prevention and Treatment

Chemical Synthesis and Antipseudomonal Activity of Al-Doped NiO Nanoparticles

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