Screening anti‐anaphylactoid components in Polygonum cuspidatum via cell membrane chromatography with LC‐MS targeting Mas‐related G protein‐coupled receptor X2
Yuanyuan Lin,
Huaqiu Lu,
Qianqian Jia
et al.
Abstract:Mas‐related G protein‐coupled receptor X2 (MrgprX2) is acknowledged as a mast cell‐specific receptor, playing a crucial role in orchestrating anaphylactoid responses through mast cell degranulation. It holds promise as a target for regulating allergic and inflammatory diseases mediated by mast cells. Polygonum cuspidatum (PC) has shown notable anti‐anaphylactoid effects, while its pharmacologically active components remain unclear. In this study, we successfully utilized MrgprX2 high‐expressing cell membrane c… Show more
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