Screening and unveiling antibacterial mechanism of dandelion phenolic extracts against
 Staphylococcus aureus
 by inhibiting intracellular Na
 +
 –K
 +
 ATPase based on molecular docking and molecular dynamics simulation

Xu, Xuefeng; Wang, Xiang; Xie, Pujun

doi:10.1080/07391102.2023.2300123

Cited by 2 publications

(1 citation statement)

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“…It is commonly used in Chinese medicine to clear away heat and toxic materials, reduce swelling and disperse masses, and promote diuresis and treat stranguria. Recent pharmacological studies have demonstrated that it possesses antibacterial, antioxidant, antiviral, liver-protecting, and choleretic effects (25)(26)(27)(28). It is commonly utilized for the prevention and treatment of respiratory and digestive tract ailments (29)(30)(31).…”

Section: Introductionmentioning

confidence: 99%

Potential for the development of Taraxacum mongolicum aqueous extract as a phytogenic feed additive for poultry

Dong,

Liu,

et al. 2024

Front. Immunol.

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IntroductionTaraxacum mongolicum (TM) is a kind of medicinal and edible homologous plant which is included in the catalogue of feed raw materials in China. It is rich in polyphenols, flavonoids, polysaccharides and other active substances, and shows many benefits to livestock, poultry and aquatic products. The study aimed to assess the potential of TM aqueous extract (TMAE) as a substitute for poultry AGPs. MethodsA total of 240 one-day-old Arbor Acker broilers were randomly assigned to four groups and fed a basal diet (Con) supplemented with 500, 1000, and 2000 mg/kg TMAE (Low, Medium, and High groups). The growth performance of the broilers was measured on day 21 and day 42. At the end of the trial, the researchers measured slaughter performance and collected serum, liver, spleen, ileum, and intestinal contents to investigate the effects of TMAE on serum biochemistry, antioxidant capacity, immune function, organ coefficient, intestinal morphology, flora composition, and short-chain fatty acids (SCFAs). ResultsThe results showed that broilers treated with TMAE had a significantly higher average daily gain from 22 to 42 days old compared to the Con group. Various doses of TMAE resulted in different levels of improvement in serum chemistry. High doses increased serum alkaline phosphatase and decreased creatinine. TMAE also increased the antioxidant capacity of serum, liver, and ileum in broilers. Additionally, middle and high doses of TMAE enhanced the innate immune function of the liver (IL-10) and ileum (Occludin) in broilers. Compared to the control group, the TMAE treatment group exhibited an increase in the ratio of villi length to villi crypt in the duodenum. TMAE increased the abundance of beneficial bacteria, such as Alistipes and Lactobacillus, while reducing the accumulation of harmful bacteria, such as Colidextracter and Sellimonas. The cecum's SCFAs content increased with a medium dose of TMAE. Supplementing broiler diets with TMAE at varying doses enhanced growth performance and overall health. The most significant benefits were observed at a dose of 1000 mg/kg, including improved serum biochemical parameters, intestinal morphology, antioxidant capacity of the liver and ileum, immune function of the liver and ileum, and increased SCFAs content. Lactobacillus aviarius, norank_f_norank_o__Clostridia_UCG-014, and Flavonifractor are potentially dominant members of the intestinal microflora. ConclusionIn conclusion, TMAE is a promising poultry feed additive and 1000 mg/kg is an effective reference dose.

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Section: Introductionmentioning

confidence: 99%

Potential for the development of Taraxacum mongolicum aqueous extract as a phytogenic feed additive for poultry

Dong,

Liu,

et al. 2024

Front. Immunol.

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Botany, Traditional Use, Phytochemistry, Pharmacology and Quality Control of Taraxaci herba: Comprehensive Review

Wu,

Sun,

Liu

et al. 2024

Pharmaceuticals

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Taraxaci herba, as a traditional Chinese medicine, is the name of the Taraxacum genus in the Asteraceae family. Documented in the Tang Herbal Medicine (Tang Dynasty, AD 657–659), its medicinal properties cover a wide range of applications such as acute mastitis, lung abscess, conjunctival congestion, sore throat, damp-heat jaundice, and vision improvement. In the Chinese Pharmacopoeia (Edition 2020), more than 40 kinds of China-patented drugs containing Taraxaci herba were recorded. This review explores the evolving scientific understanding of Taraxaci herba, covering facets of ethnopharmacology, botany, phytochemistry, pharmacology, artificial cultivation, and quality control. In particular, the chemical constituents and pharmacological research are reviewed. Taraxaci herba has been certified as a traditional medicine plant, and its flavonoids, phenolic acids, and terpenoids have been identified and separated, which include Chicoric acid, taraxasterol, Taraxasteryl acetate, Chlorogenic acid, isorhamnetin, and luteolin; they are responsible for anti-inflammatory, antioxidant, antibacterial, anti-tumor, and anti-cancer activities. These findings validate the traditional uses of Taraxaci herba and lay the groundwork for further scientific exploration. The sources used in this study include Web of Science, Pubmed, the CNKI site, classic monographs, the Chinese Pharmacopoeia, the Chinese Medicine Dictionary, and doctoral and master’s theses.

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Screening and unveiling antibacterial mechanism of dandelion phenolic extracts against Staphylococcus aureus by inhibiting intracellular Na ⁺ –K ⁺ ATPase based on molecular docking and molecular dynamics simulation

Cited by 2 publications

References 30 publications

Potential for the development of Taraxacum mongolicum aqueous extract as a phytogenic feed additive for poultry

Potential for the development of Taraxacum mongolicum aqueous extract as a phytogenic feed additive for poultry

Botany, Traditional Use, Phytochemistry, Pharmacology and Quality Control of Taraxaci herba: Comprehensive Review

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Screening and unveiling antibacterial mechanism of dandelion phenolic extracts against Staphylococcus aureus by inhibiting intracellular Na + –K + ATPase based on molecular docking and molecular dynamics simulation

Cited by 2 publications

References 30 publications

Potential for the development of Taraxacum mongolicum aqueous extract as a phytogenic feed additive for poultry

Potential for the development of Taraxacum mongolicum aqueous extract as a phytogenic feed additive for poultry

Botany, Traditional Use, Phytochemistry, Pharmacology and Quality Control of Taraxaci herba: Comprehensive Review

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Screening and unveiling antibacterial mechanism of dandelion phenolic extracts against Staphylococcus aureus by inhibiting intracellular Na ⁺ –K ⁺ ATPase based on molecular docking and molecular dynamics simulation