Abstract:Genetic findings suggested that ethnolinguistically diverse populations in China harbor differentiated genetic structure and complex evolutionary admixture history, which provide the genetic basis and theoretical foundation for forensic biogeographical ancestry inference (BGAI). Forensic assays for BGAI among intracontinental eastern Eurasians were previously conducted mainly based on the SNPs or InDels. Microhaplotypes, as a set of closely linked SNPs within 200 base pairs, possess the advantages of both STR … Show more
“…[33] confirmed significant evidence for this SNP selection in a pairwise analysis of CHB + CHD (Chinese in metropolitan Denver) and JPT (). A recent study also incorporated rs11223548 into their panel to compose microhaplotypes for ancestry inference of subpopulations within East Asia [34]. For the CHS–JPT pair, rs12665401 has the highest F ST value ( F ST = 0.2476) and exhibits a clear ability to discriminate between Southeast Asian and East Asian continental subpopulations, suggesting that markers informative in one source populations are often informative in others [35].…”
In forensic genetics, the use of ancestry informative single-nucleotide polymorphisms (AISNPs) panels can narrow the direction of the investigation by estimating an individual's biogeographic ancestry. However, distinguishing subgroups within continental regions requires more specific panels. In this study, we screened 19 AISNPs from the 1000 Genomes Project (1KG) based on their F ST values to distinguish target populations in East Asia and obtained genotypes through SNaPshot. The 19 AISNPs could divide the global population of the 1KG into five clusters and could further divide the East Asian population into four clusters: Japanese, Han Chinese, Dai Chinese, and Kinh in Ho Chi Minh City of Vietnam. In summary, the 19-AISNP panel may serve as a useful and costeffective tool for forensic ancestry inference in East Asian populations at a finer scale.
“…[33] confirmed significant evidence for this SNP selection in a pairwise analysis of CHB + CHD (Chinese in metropolitan Denver) and JPT (). A recent study also incorporated rs11223548 into their panel to compose microhaplotypes for ancestry inference of subpopulations within East Asia [34]. For the CHS–JPT pair, rs12665401 has the highest F ST value ( F ST = 0.2476) and exhibits a clear ability to discriminate between Southeast Asian and East Asian continental subpopulations, suggesting that markers informative in one source populations are often informative in others [35].…”
In forensic genetics, the use of ancestry informative single-nucleotide polymorphisms (AISNPs) panels can narrow the direction of the investigation by estimating an individual's biogeographic ancestry. However, distinguishing subgroups within continental regions requires more specific panels. In this study, we screened 19 AISNPs from the 1000 Genomes Project (1KG) based on their F ST values to distinguish target populations in East Asia and obtained genotypes through SNaPshot. The 19 AISNPs could divide the global population of the 1KG into five clusters and could further divide the East Asian population into four clusters: Japanese, Han Chinese, Dai Chinese, and Kinh in Ho Chi Minh City of Vietnam. In summary, the 19-AISNP panel may serve as a useful and costeffective tool for forensic ancestry inference in East Asian populations at a finer scale.
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