Screening and Preventive Strategies in Esophagogastric Cancer

Zakko, Liam; Lutzke, Lori S.; Wang, Kenneth K.

doi:10.1016/j.soc.2016.10.004

Cited by 19 publications

(18 citation statements)

References 85 publications

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“…[25][26][27] Because of relatively low incidence rates and high cost of endoscopy, screening of the general population for esophageal and gastric cancers in the United states has not been shown to be cost-effective. 28 However, major American gastroenterology organizations have recommended surveillance of high-risk individuals, such as some cases of Barrett's esophagus. 28 Our findings could be used to improve criteria for identifying highrisk subpopulations, although more research, particularly on novel biomarkers, is needed to develop precision screening programs.…”

Section: Discussionmentioning

confidence: 99%

“…28 However, major American gastroenterology organizations have recommended surveillance of high-risk individuals, such as some cases of Barrett's esophagus. 28 Our findings could be used to improve criteria for identifying highrisk subpopulations, although more research, particularly on novel biomarkers, is needed to develop precision screening programs.…”

Section: Discussionmentioning

confidence: 99%

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Incidence Trends of Esophageal and Gastric Cancer Subtypes by Race, Ethnicity, and Age in the United States, 1997–2014

Islami

DeSantis

Jemal

2019

Clinical Gastroenterology and Hepatology

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Incidence Trends of Esophageal and Gastric Cancer Subtypes by Race, Ethnicity, and Age in the United States, 1997–2014

Islami

DeSantis

Jemal

2019

Clinical Gastroenterology and Hepatology

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“…Our finding was in line with that (19.1) reported by Wu TY et al 19 (1998-2012). Therefore, primary prevention for avoiding known risk factors, such as cigarette smoking, drinking alcohol, and betel quid chewing, might be the best strategy to reduce morbidity and mortality from esophageal cancer 29,30 . Another relevant indicator of societal burden is the lifetime spending for healthcare services of cancer, as summarized in Table 4.…”

Section: Indicators Of Societal Burdens: Expected Years Of Life Loss mentioning

confidence: 99%

Lifetime risks, expected years of life lost, and cost-per-life year of esophageal cancer in Taiwan

Lai

Lin

Chang

et al. 2020

Sci Rep

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Besides lifetime risks, we estimated life expectancy (Le), expected years of life lost (eYLL), lifetime costs, and cost-per-LY (life-year) stratified by different stages of esophageal cancer (EC). From theTaiwan Cancer Registry, we collected 14,420 EC to estimate the incidence rates during 2008-2014. They were followed to 2015 to obtain the survival function, which was extrapolated to lifetime by a semiparametric method. We abstracted the monthly healthcare expenditures from the reimbursement database of National Health Insurance, which were multiplied with the corresponding survival probabilities to quantify lifetime cost and cost-per-LY after adjustments. About 93.7% of patients were male; 90.8% had squamous cell carcinoma. Most patients were diagnosed at advanced stages, with 44.6% and 28.3% at stages III and IV. The lifetime risk of EC in males increased in Taiwan with a cumulative incidence rate (CIR 30-84 ) of 0.0146% (2008~2010) to 0.0165% (2013-2014). The EYLL for stages I-IV were 15.8, 17.5, 20.5, and 22.5, while the average of cost-per-LY for stages I-IV were US$ 6,987, $8,776, $12,153, and $22,426. EC in Taiwan appears to have shifted into younger ages groups and incidence is still increasing. Strategies for prevention, early diagnosis and treatment are warranted to improve the cost-effectiveness and control of this cancer. ResultsThe mean age at diagnosis was younger for males than females (58.0 v.s. 65.2). Esophageal cancer in Taiwan is still more predominant in male (93.7%), and 90.8% are squamous cell carcinoma (Table 1).The incidence of squamous esophageal cancer in males increased gradually in Taiwan with a CIR 30-84 (‰) of 0.146 (2008~2010) to 0.165 (2013)(2014) (Tables 1 and 2). A shift in the highest IR to a younger age-group from 60-69 y

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“…China is a country with a high incidence of GC, with an annual incidence rate of about 19.62/100,000, and a mortality rate of about 13.44/100,000 [ 2 ]. GC screening is still considered to be the most direct and effective intervention [ 3 ]. However, China's large population and lack of medical resources cannot implement large-scale gastroscopy screening.…”

Section: Introductionmentioning

confidence: 99%

Establish a Scoring Model for High-Risk Population of Gastric Cancer and Study on the Pattern of Opportunistic Screening

Tao

Wang

Guo

et al. 2020

Gastroenterology Research and Practice

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Objective. To investigate and study the related risk factors of gastric cancer (GC) patients, to establish a high-risk scoring model of GC by multiple logistic regression analysis, and to explore the establishment of a GC screening mode with clinical opportunistic screening as the main method, and by using the pattern of opportunistic screening to establish the screening of high-risk GC patients and the choice of screening methods in the clinical outpatient work. Methods. Collected the epidemiological questionnaire of 99 GC cases and 284 non-GC patients (other chronic gastric diseases and normal) diagnosed by the General Hospital of Ningxia Medical University from October 2017 to March 2019. Serum pepsinogen (PG) levels were measured by enzyme-linked immunosorbent assay (ELISA) and confirmed Helicobacter pylori (Hp) infection in gastric mucosa tissues by Giemsa staining. Determined the high-risk factors and established a scoring model through unconditional logistic regression model analysis, and the ROC curve determined the cut-off value. Then, we followed up 26 patients of nongastric cancer patients constituted a validation group, which validated the model. Results. The high-risk factors of GC included age≥55, male, drinking cellar or well water, family history of GC, Hp infection, PGI≤43.6 μg/L, and PGI/PGII≤2.1. Established the high-risk model: Y=A×age+30×gender+30×drinking water+30×Hp infection+50×family history of GC+B×PG level. The ROC curve determined that the cut-off value for high-risk GC population was ≥155, and the area under the curve (AUC) was 0.875, the sensitivity and specificity were 87.9% and 71.5%. Conclusions. According to the risk factors of GC, using statistical methods can establish a high-risk scoring model of GC, and the score≥155 is divided into the screening cut-off value for high-risk GC population. Using this model for clinical outpatient GC screening is cost-effective and has high sensitivity and specificity.

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Screening and Preventive Strategies in Esophagogastric Cancer

Cited by 19 publications

References 85 publications

Incidence Trends of Esophageal and Gastric Cancer Subtypes by Race, Ethnicity, and Age in the United States, 1997–2014

Incidence Trends of Esophageal and Gastric Cancer Subtypes by Race, Ethnicity, and Age in the United States, 1997–2014

Lifetime risks, expected years of life lost, and cost-per-life year of esophageal cancer in Taiwan

Establish a Scoring Model for High-Risk Population of Gastric Cancer and Study on the Pattern of Opportunistic Screening

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