Screening and Matching Amphiphilic Cationic Polymers for Efficient Antibiosis

Zhao, Shuyue; Huang, Wen‐Jun; Wang, Changrong; Wang, Yaping; Zhang, Yufeng; Ye, Zhanpeng; Zhang, Jianhua; Deng, Liandong; Dong, Anjie

doi:10.1021/acs.biomac.0c01330

Cited by 40 publications

(36 citation statements)

References 68 publications

(137 reference statements)

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“…We attribute this reduced penetration through the polymeric matrix of the biofilm to the less balanced amphiphilic property. [40] Antimicrobial resistance, which is closely tied to excessive use of antimicrobials or antibiotics, is of great concern. The AMPs are known to hardly develop any bacterial resistance.…”

Section: Resultsmentioning

confidence: 99%

High Antibacterial Activity and Selectivity of the Versatile Polysulfoniums that Combat Drug Resistance

Sun

Lin

et al. 2021

Advanced Materials

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Sulfonium‐ion‐containing polymers exhibit significant potential benefits for various applications. An efficient strategy to synthesize a type of antibacterial sulfonium‐ion‐bearing polypeptoids via a combination of ring‐opening polymerization and a post‐polymerization functionalization with various functional epoxides is presented. A systematic investigation is further performed in order to explore the influence of the overall hydrophobic/hydrophilic balance on the antimicrobial activity and selectivity of the prepared polysulfoniums. Notably, those chlorepoxypropane‐modified polysulfoniums with an optimized amphiphilic balance show higher selectivity toward both Gram‐negative Escherichia coli and Gram‐positive Staphylococcus aureus, than to red blood cells. The polymers also show great efficiency in inhibiting S. aureus biofilm formations, as well as in further eradicating the mature biofilms. Remarkably, negligible antibacterial resistance and cross‐resistance to commercial antibiotics is shown in these polymers. The polysulfoniums further show their potent in vivo antimicrobial efficacy in a multidrug‐resistant S. aureus infection model that is developed on mouse skin. Similar to the antimicrobial peptides, the polysulfoniums are demonstrated to kill bacteria through membrane disruption. The obtained polypeptoid sulfoniums, with high selectivity and potent antibacterial property, are excellent candidates for antibacterial treatment and open up new possibilities for the preparation of a class of innovative antimicrobials.

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Section: Resultsmentioning

confidence: 99%

High Antibacterial Activity and Selectivity of the Versatile Polysulfoniums that Combat Drug Resistance

Sun

Lin

et al. 2021

Advanced Materials

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“…Biofilms are complex structured bacterial communities with bacterial cells embedded in extracellular polymeric substances (EPS). [50][51] Due to the presence of EPS, biofilm is more resistant to conventional antibiotics. This can result in rapid growth of antibiotic-resistant strains, raising a challenging threat in public health.…”

Section: Activities Against Biofilmsmentioning

confidence: 99%

Antibacterial Copolypeptoids with Potent Activity against Drug Resistant Bacteria and Biofilms, Excellent Stability, and Recycling Property

Zhang

Lin

et al. 2022

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The preparation of a type of innovative cationic copolypeptoid antimicrobials containing various hydrophobic moieties that resemble both structure and membrane‐lytic antibacterial mechanism of natural antimicrobial peptides (AMPs) is reported. By finely tuning the hydrophilic/hydrophobic balance, the polypeptoids exhibit a wide spectrum of antibacterial activity against both Gram‐positive bacteria and Gram‐negative bacteria with the lowest minimum inhibitory concentration (MIC) at only 2 µg mL−1, whereas they also show low haemolytic properties. In particular, high selectivity (>128) is achieved from the polymers with butyl moieties. Moreover, the polypeptoids can readily inhibit the formation of biofilms and effectively eradicate the bacteria embedded in the mature biofilms, which is superior to many natural AMPs and vancomycin. Unlike conventional antibiotics, the polypeptoids possess potent activity against drug‐resistant bacteria without visible resistance development after repeated usage. Notably, the polypeptoid antimicrobials not only have inherently fast bactericidal properties and excellent stability against incubation with human plasma, but also show excellent in vivo antibacterial effect. The prepared antimicrobials, coated onto magnetic nanospheres show recycling properties and enhanced antibacterial activity as combined with near‐infrared (NIR)‐induced photothermal antibacterial therapy.

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“…These phototherapeutic methods have a high spatiotemporal selectivity for localized tissue ablation, and thus are highly safe for applications in vivo [ 19 ]. More importantly, they are equally effective to drug-resistant and non-drug-resistant pathogenic bacteria, and will not cause bacterial resistance even if a long-term use [ 20 ]. An increasing number of investigations have been carried out for antimicrobial treatment through PTT and PDT.…”

Section: Introductionmentioning

confidence: 99%

Self-assembled nanoparticles containing photosensitizer and polycationic brush for synergistic photothermal and photodynamic therapy against periodontitis

et al. 2021

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Background Periodontitis is a chronic inflammatory disease in oral cavity owing to bacterial infection. Photothermal therapy (PTT) and photodynamic therapy (PDT) have many advantages for antibacterial treatment. As an excellent photosensitizer, indocyanine green (ICG) shows prominent photothermal and photodynamic performances. However, it is difficult to pass through the negatively charged bacterial cell membrane, thus limiting its antibacterial application for periodontitis treatment. Results In this work, self-assembled nanoparticles containing ICG and polycationic brush were prepared for synergistic PTT and PDT against periodontitis. First, a star-shaped polycationic brush poly(2-(dimethylamino)ethyl methacrylate) (sPDMA) was synthesized via atom transfer radical polymerization (ATRP) of DMA monomer from bromo-substituted β-cyclodextrin initiator (CD-Br). Next, ICG was assembled with sPDMA to prepare ICG-loaded sPDMA (sPDMA@ICG) nanoparticles (NPs) and the physicochemical properties of these NPs were characterized systematically. In vitro antibacterial effects of sPDMA@ICG NPs were investigated in porphyromonas gingivalis (Pg), one of the recognized periodontitis pathogens. A ligature-induced periodontitis model was established in Sprague–Dawley rats for in vivo evaluation of anti-periodontitis effects of sPDMA@ICG NPs. Benefiting from the unique brush-shaped architecture of sPDMA polycation, sPDMA@ICG NPs significantly promoted the adsorption and penetration of ICG into the bacterial cells and showed excellent PTT and PDT performances. Both in vitro and in vivo, sPDMA@ICG NPs exerted antibacterial and anti-periodontitis actions via synergistic PTT and PDT. Conclusions A self-assembled nanosystem containing ICG and polycationic brush has shown promising clinical application for synergistic PTT and PDT against periodontitis. Graphical Abstract

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Screening and Matching Amphiphilic Cationic Polymers for Efficient Antibiosis

Cited by 40 publications

References 68 publications

High Antibacterial Activity and Selectivity of the Versatile Polysulfoniums that Combat Drug Resistance

High Antibacterial Activity and Selectivity of the Versatile Polysulfoniums that Combat Drug Resistance

Antibacterial Copolypeptoids with Potent Activity against Drug Resistant Bacteria and Biofilms, Excellent Stability, and Recycling Property

Self-assembled nanoparticles containing photosensitizer and polycationic brush for synergistic photothermal and photodynamic therapy against periodontitis

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