Screening and management of hypothyroidism in pregnancy: Results of an Asian survey

Preconception TSH and pregnancy outcomes: a population‐based cohort study in 184 611 women

“…We should therefore be cautious whether it is clinically relevant or just noise. Although the accurate number of women who received levothyroxine supplement was unknown in the present study, an Asian survey showed that 54–79% women with TSH 2·5–5·0 mIU/l would be offered treatment. This ‘treatment effect’ may counteract the deleterious effect of SCH.…”

Maternal total T4 during the first half of pregnancy: physiologic aspects and the risk of adverse outcomes in comparison with free T4

“…[1][2][3][4] The majority of physicians use both TSH and FT4 for the assessment of maternal thyroid function during pregnancy. [5][6][7][8] However, several immunoassays may not adequately measure FT4 levels due to the high protein binding state that is present during pregnancy, particularly during late pregnancy. 9 This is one of the main reasons that current guidelines of the American Thyroid Association (ATA), the Endocrine Society (ES) and the European Thyroid Association (ETA) suggest TT4 as an alternative measure for maternal thyroid function during pregnancy.…”

Risk factors and a clinical prediction model for low maternal thyroid function during early pregnancy: two population‐based prospective cohort studies

“…The American Thyroid Association (ATA) and Endocrine Society guidelines advocate aggressive case finding based on risk factors instead of a universal screening approach. Nevertheless, a substantial number of clinicians prefer to perform universal screening over case finding (approximately 50/50 in Europe and approximately 75/25 in USA and Asia) . This state of mind is a reflection of studies showing that 30–89% of cases are missed with a case‐finding approach using risk factors recommended by international guidelines .…”