Screening and controlling canine inherited ocular diseases in Finland: epidemiological, economical and health promotional aspect

Leppanen,; Saloniemi,

doi:10.1046/j.1463-5224.1998.00037.x

Cited by 10 publications

(7 citation statements)

References 8 publications

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“…The difference in CRD and coloboma prevalences between the pooled data of 1989 to 1990 and those of 1996 to 1997 is not influenced by differences in age at examination, as all animals were examined at five to 10 weeks of age during the period from 1983 to 1997. Similar changes of prevalence for CRD and coloboma over time have been reported from Finland (Leppanen and Saloniemi 1998).…”

Section: Dfscussiwsupporting

confidence: 82%

“…The prevalence of coloboma neither increased nor decreased difference in CRD and coloboma prevalences between the pooled data of 1989 to 1990 and those of 1996 to 1997 is not influenced by differences in age at examination, as all animals were examined at five to 10 weeks of age during the period from 1983 to 1997. Similar changes of prevalence for CRD and coloboma over time have been reported from Finland (Leppanen and Saloniemi 1998). It is difficult to explain the differential change in the prevalence of C R D and coloboma under the hypothesis of simple (monogenic), autosomal, recessive inheritance of CEA. Another factor which appears to refute a hypothesis of simple recessive inheritance is the variation between countries in the prevalence of coloboma expressed as a percentage of all animals with CEA (Table l ) , as pointed out by Bjerkis (1991).…”

Section: Dfscussiwmentioning

confidence: 73%

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Influence of selective breeding on the Prevalence of chorioretinal dysplasia and coloboma in the rough collie in Sweden

Wallin-Håkanson¹,

Wallin‐Håkanson²,

Hedhammar

2000

J of Small Animal Practice

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A total of 8204 rough collies, representing 76 per cent of all collies registered by the Swedish Kennel Club between 1989 and 1997, were examined before 10 weeks of age for collie eye anomaly (CEA). All dogs were permanently identified and examination results were registered and computerised. The policy of breeders during the study period was to select against coloboma in breeding stock, but to allow breeding of chorioretinal dysplasia (CRD) affected animals. The prevalence of CRD increased significantly from 54.2 per cent to 68.1 per cent (P < 0.001) from 1989 to 1997, while the prevalence of coloboma did not (8.3 per cent to 8.5 per cent, P = 0.4). These results are not compatible with a simple, recessive, autosomal inheritance for the entire CEA complex.

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Section: Dfscussiwsupporting

confidence: 82%

Section: Dfscussiwmentioning

confidence: 73%

Influence of selective breeding on the Prevalence of chorioretinal dysplasia and coloboma in the rough collie in Sweden

Wallin-Håkanson¹,

Wallin‐Håkanson²,

Hedhammar

2000

J of Small Animal Practice

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“…A Finnish study compared affected dogs pooled into two groups (dogs born in1988 -1991 and dogs born in 1994 -1997). The authors (Leppanen and Saloniemi, 1998) detected a signifi cant increase in CEA prevalence. During our study period, no signifi cant changes in the incidence of CEA were observed but it seems to have increased from 31.58 % in Rough Collie (Kellner, 1985) to 40.1 % in the current study, although strict breeding regulations were always in effect.…”

Section: Discussionmentioning

confidence: 93%

Collie Eye Anomaly in Switzerland

Walser-Reinhardt¹,

Hässig²,

Spiess³

2009

Schweizer Archiv für Tierheilkunde

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In this retrospective study, the results of 3'527 eye examinations in 6 different breeds affected with Collie Eye Anomaly (CEA) over a period of 8 years (1999 -2007) are described. CEA was divided into three main ophthalmoscopic features, a) choroidal hypoplasia (CRH), b) CRH and coloboma and c) coloboma alone. Of the 101 Smooth Collies 8.9 % showed signs of CRH, whereas 36.9 % of Rough Collies were affected with CRH, 2.8 % with CRH and coloboma and 0.38 % with coloboma alone. Choroidal hypoplasia was present in 13.1 %, CRH and coloboma in 1.8 % and coloboma alone in 0.2 % of the Shetland Sheepdogs. Only one Australian Shepherd dog had CRH, while 0.7 % of the Border Collies were affected with CRH. None of the Nova Scotia Duck Tolling Retrievers were affected with CEA. There were no statistically significant differences in the occurrence of CEA between males and females, nor was there any relation between coat colors. Significant differences could be shown between dogs younger or older than 8 weeks at first examination. CEA was more often diagnosed in dogs younger than 8 weeks within the Rough Collie and Shetland Sheepdog L. Walser-Reinhardt, M. Hässig, B.Spiess, Band 151, Heft 12, Dezember 2009, 597 -603 DOI 10.1024/0036-7281.151.12.597 Schweiz. Arch. Tierheilk. © 2009 Originalarbeiten AbstractIn this retrospective study, the results of 3'527 eye examinations in 6 different breeds affected with Collie Eye Anomaly (CEA) over a period of 8 years (1999 -2007) are described. CEA was divided into three main ophthalmoscopic features, a) choroidal hypoplasia (CRH), b) CRH and coloboma and c) coloboma alone. Of the 101 Smooth Collies 8.9 % showed signs of CRH, whereas 36.9 % of Rough Collies were affected with CRH, 2.8 % with CRH and coloboma and 0.38 % with coloboma alone. Choroidal hypoplasia was present in 13.1 %, CRH and coloboma in 1.8 % and coloboma alone in 0.2 % of the Shetland Sheepdogs. Only one Australian Shepherd dog had CRH, while 0.7 % of the Border Collies were affected with CRH. None of the Nova Scotia Duck Tolling Retrievers were affected with CEA. There were no statistically signifi cant differences in the occurrence of CEA between males and females, nor was there any relation between coat colors. Signifi cant differences could be shown between dogs younger or older than 8 weeks at fi rst examination. CEA was more often diagnosed in dogs younger than 8 weeks within the Rough Collie and Shetland Sheepdog.Keywords: Collie eye anomaly, choroidal hypoplasia, coloboma, collies Collie Augenanomalie (CEA) in der SchweizIn dieser retrospektiven Studie werden die Resultate von 3'527 Augenuntersuchungen über einen Zeitraum von 8 Jahren (1999 -2007)

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“…The distribution of CEA obtained from those surveys varied across affected breeds. Regarding the large-scale studies in Rough and Smooth Collies, the overall prevalence of affected dogs was approximately 30.95%-40.6% in Finland [15], Switzerland [16], Norway [17], and the Netherlands [18]. In addition, a high prevalence of about 64% and 75.5% was observed in the UK [5] and Denmark [19], respectively.…”

Section: Discussionmentioning

confidence: 99%

A novel multiplex polymerase chain reaction assay for the genotypic survey of the non-homologous end-joining factor 1 gene associated with Collie eye anomaly in Thailand

Lerdkrai

Phungphosop

2022

Vet World

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Background and Aim: Collie eye anomaly (CEA) is a hereditary and congenital ocular disorder, which affects several dog breeds, including Collies, Collie-related breeds, and other purebreds. An intronic deletion of 7799-bp in the non-homologous end-joining factor 1 (NHEJ1) gene has been identified as the genetic defect causing CEA. This study aimed to investigate the prevalence of CEA based on NHEJ1 genotyping assay in Thailand. Materials and Methods: We clarified the prevalence of CEA in 224 dogs from five purebred dog breeds using a novel multiplex polymerase chain reaction (PCR)-based technique and confirmed the genotypic status with direct DNA sequencing. Results: The highest frequency of the mutated NHEJ1 allele was 83.3% for Rough Collies, followed by 7.8% for Border Collies, 5.1% for Australian Shepherds, and 2.8% for Shetland Sheepdogs. The heterozygous mutated NHEJ1 genotype detected for Rough Collies, Border Collies, Australian Shepherds, and Shetland Sheepdogs was 33.3%, 15.6%, 10.3%, and 3.3%, respectively. The homozygous mutated NHEJ1 genotype was detected only in Rough Collies and Shetland Sheepdogs, accounting for 66.7% and 1.1%, respectively. Thai Ridgeback Dogs were not affected by this mutation. Conclusion: This study describes, for the 1st time, the genotypic survey of the NHEJ1 gene associated with CEA in dogs in Thailand. In addition, we successfully developed a new multiplex PCR assay with high accuracy, reproducibility, and cost-efficiency and validated its usefulness for determining NHEJ1 genotypes.

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Screening and controlling canine inherited ocular diseases in Finland: epidemiological, economical and health promotional aspect

Cited by 10 publications

References 8 publications

Influence of selective breeding on the Prevalence of chorioretinal dysplasia and coloboma in the rough collie in Sweden

Influence of selective breeding on the Prevalence of chorioretinal dysplasia and coloboma in the rough collie in Sweden

Collie Eye Anomaly in Switzerland

A novel multiplex polymerase chain reaction assay for the genotypic survey of the non-homologous end-joining factor 1 gene associated with Collie eye anomaly in Thailand

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