2011
DOI: 10.1007/s00251-011-0529-5
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Screening and confirmatory testing of MHC class I alleles in pig-tailed macaques

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Cited by 29 publications
(33 citation statements)
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“…Future experiments using passive antibody transfer, adoptive T cell transfer, and antibody- mediated depletion of lymphocyte subsets will help to delineate the distinct roles of these cells in mediating cross-protection. Major histocompatibility complex (MHC)-matched primate models have recently been developed that should assist in this work (54,55). Second, we studied a limited number of animals (12 in total), making it difficult to correlate specific immune responses with heightened protection.…”
Section: Discussionmentioning
confidence: 99%
“…Future experiments using passive antibody transfer, adoptive T cell transfer, and antibody- mediated depletion of lymphocyte subsets will help to delineate the distinct roles of these cells in mediating cross-protection. Major histocompatibility complex (MHC)-matched primate models have recently been developed that should assist in this work (54,55). Second, we studied a limited number of animals (12 in total), making it difficult to correlate specific immune responses with heightened protection.…”
Section: Discussionmentioning
confidence: 99%
“…Putative Mane-A and Mane-B haplotypes were inferred by identifying combinations of shared alleles between animals as described previously for rhesus macaques (35). MHC-I typing data for 5 out of the 44 macaques have been previously reported (33). The MHC-I typing data are available on request.…”
Section: Methodsmentioning
confidence: 99%
“…The resulting sequencing data were binned by multiplex identifier, and sequence reads from each animal were assembled into unidirectional contigs having 100% identity using a custom genotyping analysis work flow (LabKey, USA). The number of sequence reads comprising each unidirectional contig was enumerated, and the resulting consensus sequences were mapped against an in-house database containing known pig-tailed MHC-I allele sequences using the BLASTn program (33)(34)(35). Putative Mane-A and Mane-B haplotypes were inferred by identifying combinations of shared alleles between animals as described previously for rhesus macaques (35).…”
Section: Methodsmentioning
confidence: 99%
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“…Mane-A and 22 Mane-B MHC Class I alleles have been identified, and further characterization of the frequency and distribution of at least 10 of these alleles was performed in pigtail macaques of Indonesian, North American, and Australian origin [74,75]. New alleles continue to be identified as the genetic characterization of pigtail macaques progresses, and this is likely to increase their application in vaccine research.…”
Section: Pigtail Macaques (Macaca Nemestrina)mentioning
confidence: 99%