Screening and Biosensor-Based Approaches for Lung Cancer Detection

Wang, Lulu

doi:10.3390/s17102420

Cited by 47 publications

(18 citation statements)

References 196 publications

(232 reference statements)

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“…However, these immunoassay tests require expensive and complex instruments and expert operators 5 . Besides, there is the risk of hazardous radioactive elements that may cause to harmful effects on the patients' body 6 . Regarding improving tumor biomarkers detection, novel bio‐affinity sensors have widely studied and have satisfactorily used for addressing all the aforementioned issues and have considered as efficient analytical tools 7 .…”

Section: Introductionmentioning

confidence: 99%

Chemical binding of molecular‐imprinted polymer to biotinilated antibody: Utilization of molecular imprinting polymer as intelligent synthetic biomaterials toward recognition of carcinoma embryonic antigen in human plasma sample

Abdollahiyan

Mohammadzadeh

Hasanzadeh

2021

J of Molecular Recognition

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In this study, a novel biosensor based on molecular imprinting polymer (MIP) methodology was fabricated toward recognition of carcinoembryonic antigen (CEA). For this purpose, poly (toluidine blue) (PTB) was electropolymerized on the surface of gold electrode in the absence and presence of CEA. So, the target molecules were entrapped into the imprinted specific cavities of MIP. Obtained results show that, the binding affinity of the MIP system was significantly higher than that of revealed for the nonimprinted polymer (NIP) system, MIP‐based biosensor revealed linear response from (0.005 to 75 μg/L) and low limit of quantification of (0.005 μg/L) by using chronoamperometry technique, leading to CEA monitoring in real and clinical samples. Thus, a novel technique for rapid, simple, sensitive and affordable monitoring of CEA (LLOQ = 0.005 μg/L) has provided through developed biosensor. From a future perspective, moreover, this method can be considered as an applicable candidate in biomedical and clinical analysis for point‐of‐care usages.

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Section: Introductionmentioning

confidence: 99%

Chemical binding of molecular‐imprinted polymer to biotinilated antibody: Utilization of molecular imprinting polymer as intelligent synthetic biomaterials toward recognition of carcinoma embryonic antigen in human plasma sample

Abdollahiyan

Mohammadzadeh

Hasanzadeh

2021

J of Molecular Recognition

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“… 4 However, many diagnosed patients are already in late stages. 5 Although PET and CT are developing progressively higher resolutions and can detect smaller tumors, they are radiational and expensive.…”

Section: Introductionmentioning

confidence: 99%

Identification of tumor-educated platelet biomarkers of non-small-cell lung cancer

Sheng

Dong

Xie

2018

OTT

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BackgroundLung cancer is a severe cancer with a high death rate. The 5-year survival rate for stage III lung cancer is much lower than stage I. Early detection and intervention of lung cancer patients can significantly increase their survival time. However, conventional lung cancer-screening methods, such as chest X-rays, sputum cytology, positron-emission tomography (PET), low-dose computed tomography (CT), magnetic resonance imaging, and gene-mutation, -methylation, and -expression biomarkers of lung tissue, are invasive, radiational, or expensive. Liquid biopsy is non-invasive and does little harm to the body. It can reflect early-stage dysfunctions of tumorigenesis and enable early detection and intervention.MethodsIn this study, we analyzed RNA-sequencing data of tumor-educated platelets (TEPs) in 402 non-small-cell lung cancer (NSCLC) patients and 231 healthy controls. A total of 48 biomarker genes were selected with advanced minimal-redundancy, maximal-relevance, and incremental feature-selection (IFS) methods.ResultsA support vector-machine (SVM) classifier based on the 48 biomarker genes accurately predicted NSCLC with leave-one-out cross-validation (LOOCV) sensitivity, specificity, accuracy, and Matthews correlation coefficients of 0.925, 0.827, 0.889, and 0.760, respectively. Network analysis of the 48 genes revealed that the WASF1 actin cytoskeleton module, PRKAB2 kinase module, RSRC1 ribosomal protein module, PDHB carbohydrate-metabolism module, and three intermodule hubs (TPM2, MYL9, and PPP1R12C) may play important roles in NSCLC tumorigenesis and progression.ConclusionThe 48-gene TEP liquid-biopsy biomarkers will facilitate early screening of NSCLC and prolong the survival of cancer patients.

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“…Radiation damage tumor as well as normal cells by generating free radicals 14,15 . To obtain better results from the high dose of radiotherapy, the surrounding normal tissues should be protected against radiation 16 . Thus, the radioprotective agents are very important in clinical radiotherapy 14 .…”

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confidence: 99%

Untitled

Neupane¹,

Adhikari²,

Alok³

et al. 2021

IJPSR

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The noble coronavirus SARS-CoV-2 results in a devastating, multisystem disease among which COVID-19 pneumonia creates serious complications and most of COVID-19 related deaths. COVID-19 patients develop a systemic inflammatory response through interleukin (IL) and tumor necrosis factors. In COVID-19 patients, cytokine storm controlling is the key step for treatment because cytokine attacks own body cells instead of fighting with the virus. We reviewed several literatures to summarize the safety and efficacy of LD-RT in COVID-19 patients. Low dose chest radiation may reduce the inflammation in the lungs in severely ill patients. The radiation offset an immune system called AS a cytokine storm. Several randomized/non-randomized, single/multi-centered, open/close clinical trials are underway in U.S, India, Iran and around the globe. Early studies showed LD-RT reduces the inflammatory cytokines, time of hospitalization, duration of ventilation, and a number of deaths. However, some researchers warned for radiation-induced cancer (lung, breast, and esophageal) and cardiovascular diseases. So, further extensive preclinical studies should be conducted to identify the risk-benefit ratio in COVID-19 patients.

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Screening and Biosensor-Based Approaches for Lung Cancer Detection

Cited by 47 publications

References 196 publications

Chemical binding of molecular‐imprinted polymer to biotinilated antibody: Utilization of molecular imprinting polymer as intelligent synthetic biomaterials toward recognition of carcinoma embryonic antigen in human plasma sample

Chemical binding of molecular‐imprinted polymer to biotinilated antibody: Utilization of molecular imprinting polymer as intelligent synthetic biomaterials toward recognition of carcinoma embryonic antigen in human plasma sample

Identification of tumor-educated platelet biomarkers of non-small-cell lung cancer

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