Screening and antibacterial efficacy of selected Indian medicinal plants

Mickymaray, Suresh; Aboody, Mohammed Saleh Al; Rath, Pradipta Kumar; Panneerselvam, A.; Thajuddin, Nooruddin

doi:10.1016/j.apjtb.2015.12.005

Cited by 60 publications

(40 citation statements)

References 36 publications

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“…The species of the plant kingdom are estimated to number about 500,000 and only a minor portion of them have been investigated for antimicrobial activity [9,14]. Traditional medicinal plants can be cultivated by humans over centuries without existing systematic standards and analysis due to their safety and efficacy.…”

Section: Traditional Medicinal Plantsmentioning

confidence: 99%

“…Nowadays, studies are progressively turning their consideration to traditional medicine and advancing better drugs to treat diabetes, cancer, and microbial infections [15,16]. A large number of studies have been piloted using medicinal plant extracts and their active principles on bacteria, fungi, algae, and viruses in different localities of the world [9,10]. Various families of traditional medicinal plants have been scientifically tested for their antimicrobial activities and are presented in Table 1.…”

Section: Traditional Medicinal Plantsmentioning

confidence: 99%

“…Plant-derived antimicrobials have been established to be one of the most auspicious sources considered as safe due to their natural origin when compared with synthetic compounds [9,10]. There is an accumulating interest in the practice of either crude extract of medicinal plants, as well as the screening plant-derived compounds as an alternative therapy for microbial infections [11].…”

Section: Introductionmentioning

confidence: 99%

“…Plant-derived compounds are a group of secondary metabolites that are used to treat chronic as well as infectious diseases. These traditional medicinal plants or active compounds remain included as part of the habitual treatment of various maladies [9]. These compounds could have other target sites than conventional antimicrobials as well as diverse mechanisms of action against pathogenic microbes.…”

Section: Introductionmentioning

confidence: 99%

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Efficacy and Mechanism of Traditional Medicinal Plants and Bioactive Compounds against Clinically Important Pathogens

Mickymaray

2019

Antibiotics

110

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Traditional medicinal plants have been cultivated to treat various human illnesses and avert numerous infectious diseases. They display an extensive range of beneﬁcial pharmacological and health effects for humans. These plants generally synthesize a diverse range of bioactive compounds which have been established to be potent antimicrobial agents against a wide range of pathogenic organisms. Various research studies have demonstrated the antimicrobial activity of traditional plants scientifically or experimentally measured with reports on pathogenic microorganisms resistant to antimicrobials. The antimicrobial activity of medicinal plants or their bioactive compounds arising from several functional activities may be capable of inhibiting virulence factors as well as targeting microbial cells. Some bioactive compounds derived from traditional plants manifest the ability to reverse antibiotic resistance and improve synergetic action with current antibiotic agents. Therefore, the advancement of bioactive-based pharmacological agents can be an auspicious method for treating antibiotic-resistant infections. This review considers the functional and molecular roles of medicinal plants and their bioactive compounds, focusing typically on their antimicrobial activities against clinically important pathogens.

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Section: Traditional Medicinal Plantsmentioning

confidence: 99%

Section: Traditional Medicinal Plantsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Efficacy and Mechanism of Traditional Medicinal Plants and Bioactive Compounds against Clinically Important Pathogens

Mickymaray

2019

Antibiotics

110

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“…Diante disso, existe a necessidade de estudos visando novos compostos com propriedades antimicrobianas, sendo relevante investir em pesquisas que visem identificar novas substâncias moleculares ativos. Para tanto, as plantas se apresentam como fonte de pesquisa para identificação de novos metabólitos que possuam tais propriedades, uma vez que já se conhece diversas propriedades medicinais (KALAYCI, 2016;MICKYMARAY et al, 2016;MONTE et al, 2014).…”

Section: Atividade Antimicrobianaunclassified

Estudo fitoquímico e atividades biológicas da espécie Banisteriopsis campestris (A. Juss.) Little

Rocha¹

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Neste trabalho, o estudo fitoquímico e atividade biológica da espécie Banisteriopsis campestris, que é endêmica no Brasil com distribuição geográfica nos Biomas da Caatinga e do Cerrado, foi realizado. O presente trabalho avaliou as atividades antimicrobiana, antifúngica, antioxidante, antileishmania, citotóxica e inibitória contra α-amilase e α-glicosidase, e glicação dos óleos essenciais, extratos e partições de partes da planta, além de caracterizar e/ou determinar a estrutura dos constituintes químicos presentes nas partições e óleos essenciais. Para desenvolvimento do trabalho, extratos etanólicos das folhas, caules e raízes, foram preparados e particionados com solventes de polaridade crescente, gerando as partições de hexano, diclorometano, acetato de etila, n-butanol e a partição residual chamada de metanol/água. Todos os extratos e partições foram submetidos à prospecção fitoquímica, determinação de teores de fenóis totais, proantocianidinas, flavonoides, atividade antioxidante pelos métodos DPPH e ORAC, ensaio de inibição da α-amilase, αglicosidase e glicação, avaliação das atividades antimicrobiana e antifúngica, além das análises dos constituintes presentes nas partições mais ativas por CLAE/EM. Os óleos essenciais das flores, folhas, caules e raízes foram extraídos por hidrodestilação, identificados por CG/EM e realizadas análises de atividade antimicrobiana, antifúngica, antileishmania, antioxidante e citotóxica. Foram identificados por prospecção fitoquímica, terpenos, flavonóides e compostos fenólicos, presentes nos extratos e partições. As partições acetato de etila e n-butanol foram as que exibiram melhores resultados para atividade antioxidante, inibitória para α-amilase e α-glicosidase.A partição acetato de etila das folhas, caule e raiz foram analisadas por CLAE/EM e foram identificadas em suas composições, ácidos orgânicos, flavonoides e procianidinas do tipo B1, B2 e C3. A partição hexano do caule teve excelentes valores de concentração inibitória mínima (CIM) para as bactérias aeróbias e anaeróbias, com valores de CIM abaixo de 50 µ mL -1 contra as bactérias Porphyromonas gingivalis, Fusobacterium nucleatum e Actinomyces naeslundii. Nos óleos essenciais os principais compostos identificados na raiz e caule foram ácidos graxos; nas folhas foram identificadas além destes ácidos graxos, como compostos principais, o alfa terpineol, fitol e esqualeno. O óleo essencial da flor apresentou aproximadamente 9% de monoterpenos, 14,5% de sesquiterpenos destacando-se, alfa-terpineol e (E)-nerolidol.Os óleos essenciais apresentaram atividade antiprotozoária contra Leishmania amazonensis e os óleos do caule e raízes apresentaram baixa citotoxidade contra as linhagens de células Vero. Os óleos também inibiram o crescimento de todas as bactérias orais testadas, com destaque para o óleo das raízes com potente atividade antibacteriana com inibição para todas as espécies de bactérias com valores de CIM variando de 12,5 a 100 μg mL -1 . Os óleos do caule e raízes foram os que exibiram melhores resultados de at...

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Dietary phytochemicals modulate intestinal epithelial barrier dysfunction and autoimmune diseases

et al. 2021

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The intestinal epithelium acts as a key defensive barrier that protects internal organs from the detrimental gut environment. The homeostasis of the gut epithelium may be altered by environmental conditions and exogenous pathogens that can impair the integrity of the gut barrier, leading to immune response associated with low‐grade systemic inflammation, a known contributor to metabolic and inflammatory diseases. Autoimmune diseases (ADs) are a collection of abnormalities of the immune system, in which the immune system of an individual acts against healthy organs or systems, due to a failure in antigenic recognition. Hence, this review aims to focus on modulators of intestinal epithelial barrier dysfunction with effects on autoimmune disorders. All data on dietary phytochemicals and their impact on the modulation of the intestinal epithelium barrier and various ADs were collected from electronic searches of library databases (PubMed, Science Direct, and Google Scholar). An electronic search was conducted using PubMed, Science Direct, and Google Scholar by finding the keywords “phytochemicals” AND “bioactive compounds” AND “flavonoids” AND “polyphenols” OR “intestinal epithelium barrier” OR “autoimmune diseases” OR “inflammatory diseases” in “Title/Abstract/Keywords,” with the date from January 2011 to December 2020, to identify all published studies (in vitro, in vivo, clinical, and case‐control) that have investigated the connection between dietary phytochemicals and their various beneficial effects. Dietary phytochemicals are promising key modulators, stabilizing the integrity of the intestinal barrier and attenuating the progression of ADs. Health‐modulatory information was gathered and orchestrated in a suitable place in this review.

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Screening and antibacterial efficacy of selected Indian medicinal plants

Cited by 60 publications

References 36 publications

Efficacy and Mechanism of Traditional Medicinal Plants and Bioactive Compounds against Clinically Important Pathogens

Efficacy and Mechanism of Traditional Medicinal Plants and Bioactive Compounds against Clinically Important Pathogens

Estudo fitoquímico e atividades biológicas da espécie Banisteriopsis campestris (A. Juss.) Little

Dietary phytochemicals modulate intestinal epithelial barrier dysfunction and autoimmune diseases

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