Screen-printed carbon electrode modified with de-bundled single-walled carbon nanotubes for voltammetric determination of norepinephrine in ex vivo rat tissue

Rajarathinam, Thenmozhi; Thirumalai, Dinakaran; Kwon, Minho; Lee, Seulah; Jayaraman, Sivaguru; Paik, Hyun‐jong; Lee, Jaewon; Chang, Seung‐Cheol

doi:10.1016/j.bioelechem.2022.108155

Cited by 16 publications

(3 citation statements)

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“…After ingestion through food, water, and air, the human body metabolizes and eliminates heavy metals in various ways, primarily through urine. The concentration of heavy metals in urine provides an indication of the body's metal levels after metabolism (14,15). The International Association for Research on Cancer (IARC) has classified beryllium and beryllium-containing compounds as Group 1 carcinogens.…”

Section: Introductionmentioning

confidence: 99%

Association between urinary metals and prostate-specific antigen in aging population with depression: a cross-sectional study

Ren,

Zhang,

2024

Front. Public Health

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ObjectiveThis study aims to investigate the impact of depression and urinary metals on Prostate-Specific Antigen (PSA).MethodsAnalysis was conducted on 1901 samples collected from the National Health and Nutrition Examination Survey (NHANES) database between 2001 and 2010. Analytical methods included stepwise multiple linear regression (MLR) analysis of the overall population’s urinary metals and PSA relationship, analysis of urinary metals and PSA relationship in older adults and BMI subgroups, analysis of urinary metals and PSA relationship in the depressed population, and restricted cubic spline (RCS) analysis. A significance level of p < 0.05 was considered statistically significant.ResultsIn the stepwise multiple linear regression, beryllium (Be) showed a dose–response association with PSA (third quartile: β = 0.05, 95%CI (0.02, 0.09); fourth quartile: β = 0.07, 95%CI (0.02, 0.12), p trend = 0.048). Subgroup analysis indicated that in individuals aged >60, Be at Q4 level [β = 0.09, 95%CI (0.05, 0.21)] exhibited a dose–response correlation with PSA. In the population with 25 ≤ BMI < 30, Be might more significantly elevate PSA, with Q4 level having a pronounced impact on PSA levels [β = 0.03, 95%CI (0.02, 1.27)]. In the depressed population, urinary cadmium (Cd) levels showed a significant positive dose–response relationship, with Q4 level of Cd having the maximum impact on PSA [β = 0.3, 95%CI (0.09, 0.49)].ConclusionIndividuals exposed to beryllium (Be), especially the older adults and overweight, should monitor their PSA levels. In depressed patients, cadmium (Cd) levels may further elevate PSA levels, necessitating increased monitoring of PSA levels among males.

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Section: Introductionmentioning

confidence: 99%

Association between urinary metals and prostate-specific antigen in aging population with depression: a cross-sectional study

Ren,

Zhang,

2024

Front. Public Health

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“…Given the roles played by epinephrine in human physiology and its importance as a biomarker, medicine, and diagnostic tool for various diseases, there has been a growing interest in the selective detection of epinephrine using fluorescence, [25–28] chemical luminescence, high‐performance liquid chromatography (HPLC), [29] capillary electrophoreses, [30] polarography, [31] gas chromatography(GC)‐mass spectrometry, [32] and Raman spectroscopy [33] . The easy oxidation of catecholamine makes them an excellent candidate for electrochemical methods for quantitative analysis [34,35] . However, epinephrine detection through electrochemical methods is challenging for various reasons.…”

Section: Introductionmentioning

confidence: 99%

“…[33] The easy oxidation of catecholamine makes them an excellent candidate for electrochemical methods for quantitative analysis. [34,35] However, epinephrine detection through electrochemical methods is challenging for various reasons. The oxidation of epinephrine generates adrenochrome that can get polymerized easily, leading to poisoning and blocking of electrode surfaces.…”

Section: Introductionmentioning

confidence: 99%

Highly Selective and Quantitative Point‐of‐Care Diagnostic Method for Adrenaline

Koppayithodi

Jana

Bandyopadhyay

2023

Chemistry A European J

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Adrenaline, also known as epinephrine, is a neurotransmitter/hormone that is an important target in diagnostics. Development of an effective method for detecting it in the presence of other neurotransmitters is a challenging task. The electrochemical and fluorescent techniques commonly used have low selectivity in distinguishing among catecholamines. Herein, a small‐molecule organic probe with an activated furfural moiety is reported to exploit the nucleophilicity of epinephrine to generate a bright‐colored donor–acceptor Stenhouse adduct. Among nine common neurotransmitters or their analogues, only epinephrine was found to generate a unique colour change discernible with the naked eye, whereas the other ones remain unaffected. Under various in‐field detection conditions, including solution, droplet, and paper strip‐based detection, the colour change were also noticeable. The low detection limit of 1.37 nM and a limit of quantitation of 4.37 nM were achieved with simple UV/Vis methods in addition to the sub‐ppm level sensing under visual conditions with naked eyes. The probe could be used for practical colorimetric measurements as a point‐of‐care tool without any complex and expensive machinery, making this approach accessible to all. In addition, using a simple smartphone, the determination of epinephrine concentrations is possible by using machine‐learning techniques.

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A novel and reusable sensing platform for electrochemical detection of norepinephrine based on nitrogen-doped porous carbon anchored CoFe2O4@NiO nanocomposite

et al. 2023

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Screen-printed carbon electrode modified with de-bundled single-walled carbon nanotubes for voltammetric determination of norepinephrine in ex vivo rat tissue

Cited by 16 publications

References 44 publications

Association between urinary metals and prostate-specific antigen in aging population with depression: a cross-sectional study

Association between urinary metals and prostate-specific antigen in aging population with depression: a cross-sectional study

Highly Selective and Quantitative Point‐of‐Care Diagnostic Method for Adrenaline

A novel and reusable sensing platform for electrochemical detection of norepinephrine based on nitrogen-doped porous carbon anchored CoFe2O4@NiO nanocomposite

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