Abstract:We know that screening for breast cancer leads to detection of smaller tumours with less lymph node metastases. Could it be possible that the decrease in mortality after screening is not only caused by this earlier stage, but also by a different mitotic activity index (MAI) of the tumours that are detected by screening? Is MAI a prognostic factor for recurrence-free survival? A retrospective study was carried out of 387 patients with breast cancer, treated at the University Hospital Nijmegen between January 19… Show more
“…Data from the National Cancer Institute's Surveillance Epidemiology and End Results (SEER) program stated that breast cancer mortality rate declined by 2.3% each year between 1990 and 2003 after effective breast screening in USA (SEER, 2005). Breast cancers detected by screening mammography are smaller and have a more favorable prognosis compared to tumors detected outside the screening (Gilliland et al, 2000;Groenendijk et al, 2000;Joensuu et al, 2004). Therefore, screening mammography has been claimed as the most valuable tool for detection of early breast cancer.…”
Background: The Bahcesehir Breast Cancer Screening Project is the first organized population based breast cancer mammographic screening project in Turkey. The objective of this prospective observational study was to demonstrate the feasibility of a screening program in a developing country and to determine the appropriate age (40 or 50 years old) to start with screening in Turkish women. Materials and Methods: Between January 2009 to December 2010, a total of 3,758 women aged 40-69 years were recruited in this prospective study. Screening was conducted biannually, and five rounds were planned. After clinical breast examination (CBE), two-view mammograms were obtained. True positivity, false positivity, positive predictive values (PPV) according to ACR, cancer detection rate, minimal cancer detection rate, axillary node positivity and recall rate were calculated. Breast ultrasound and biopsy were performed in suspicious cases. Results: Breast biopsy was performed in 55 patients, and 18 cancers were detected in the first round. The overall cancer detection rate was 4.8 per 1,000 women. Most of the screened women (54%) and detected cancers (56%) were in women aged 40-49. Ductal carcinoma in situ (DCIS) and stage I cancer and axillary node positivity rates were 22%, 61%, and 16.6%, respectively. The positive predictivity for biopsy was 32.7%, whereas the overall recall rate was 18.4 %. Conclusions: Preliminary results of the study suggest that population based organized screening are feasible and age of onset of mammographic screening should be 40 years in Turkey.
“…Data from the National Cancer Institute's Surveillance Epidemiology and End Results (SEER) program stated that breast cancer mortality rate declined by 2.3% each year between 1990 and 2003 after effective breast screening in USA (SEER, 2005). Breast cancers detected by screening mammography are smaller and have a more favorable prognosis compared to tumors detected outside the screening (Gilliland et al, 2000;Groenendijk et al, 2000;Joensuu et al, 2004). Therefore, screening mammography has been claimed as the most valuable tool for detection of early breast cancer.…”
Background: The Bahcesehir Breast Cancer Screening Project is the first organized population based breast cancer mammographic screening project in Turkey. The objective of this prospective observational study was to demonstrate the feasibility of a screening program in a developing country and to determine the appropriate age (40 or 50 years old) to start with screening in Turkish women. Materials and Methods: Between January 2009 to December 2010, a total of 3,758 women aged 40-69 years were recruited in this prospective study. Screening was conducted biannually, and five rounds were planned. After clinical breast examination (CBE), two-view mammograms were obtained. True positivity, false positivity, positive predictive values (PPV) according to ACR, cancer detection rate, minimal cancer detection rate, axillary node positivity and recall rate were calculated. Breast ultrasound and biopsy were performed in suspicious cases. Results: Breast biopsy was performed in 55 patients, and 18 cancers were detected in the first round. The overall cancer detection rate was 4.8 per 1,000 women. Most of the screened women (54%) and detected cancers (56%) were in women aged 40-49. Ductal carcinoma in situ (DCIS) and stage I cancer and axillary node positivity rates were 22%, 61%, and 16.6%, respectively. The positive predictivity for biopsy was 32.7%, whereas the overall recall rate was 18.4 %. Conclusions: Preliminary results of the study suggest that population based organized screening are feasible and age of onset of mammographic screening should be 40 years in Turkey.
“…Screen-detected (SD) cancers are less likely to have axillary lymph node metastases, poor histological differentiation, high mitotic index, high S phase fraction, and low levels of hormone receptor expression [1][2][3][4]. Multivariate studies have associated SD cancers with a decreased risk of lymph node metastases even after adjustment for tumour size [1,3], histological grade, hormone receptor status, and DNA ploidy [3].…”
“…Compared with cancers found by the patient herself, cancers detected in screening are usually smaller in size and are usually better differentiated and contain less tumor necrosis, have lower mitotic counts, express less frequently TP53 or HER2, have higher estrogen receptor (ER) and progesterone receptor (PR) contents, and are less frequently associated with regional lymph node metastases (4)(5)(6)(7)(8).…”
Purpose: The frequency and significance of gene expression profile-derived molecular subtypes of breast cancers found in mammography screening are unknown. Experimental Design: We identified breast cancers diagnosed in women of any age living in defined geographic regions in Finland in 1991 to 1992 and collected clinical and pathologic data. Surrogates for the molecular subtypes were determined for 247 cancers found in organized mammography screening and 989 cancers detected outside of screening using immunohistochemistry or in situ hybridization. Molecular subtypes were defined as luminal A [estrogen receptor (ER) positive and/or progesterone receptor (PR) positive, HER2-], luminal B (ER+ and/ or PR+, HER2+), basal-like (ER-, PR-, HER2-, cytokeratin 5+, and/or HER1+), HER2+/ER-(ER-, PR-, and HER2+), and unclassified. The median follow-up time was 9.4 years. Results: The luminal type A was common (73.7%) and the HER2+/ER-type is rare (5.7%) in screen-detected cancer, and only 16% were HER2 positive. Women with cancer diagnosed in screening at ages 50 to 69 years had similar molecular subtype distribution as women whose cancer was found outside of screening at age >69 years. In a multivariate model, cancer detection at screening independently predicted favorable distant disease-free survival when the molecular subtype was included as a covariate in addition to age, histologic grade, and cancer size. Women with small (pT 1 N 0 M 0 ) HER2-positive cancer had similar outcome regardless of the method of detection. Conclusions: Molecular subtype distribution of screen-detected breast cancer differs from that of cancers found outside of screening and accounts in part for the better outcome of screen-detected cancer.
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